ADOPTIVE CELL TRANSFER INCORPORATING VACCINATION (ACTIV) THERAPY FOR CANCER

A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer.

Aesha I Ali, Minyu Wang, Bianca von Scheidt, Pilar M Dominguez, Aaron J Harrison, Daniela Gm Tantalo, Jian Kang, Amanda J Oliver, Jack D Chan, Xin Du, Yuchen Bai, Belinda Lee, Ricky W Johnstone, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

2021-09-02

PURPOSE: In this article, we describe a combination chimeric antigen receptor (CAR) T-cell therapy that eradicated the majority of..

Enhancing co-stimulation of CAR T cells to improve treatment outcomes in solid cancers

Aaron J Harrison, Xin Du, Bianca von Scheidt, Michael H Kershaw, Clare Y Slaney

2021-01-01

<jats:title>Summary</jats:title> <jats:p>Co-stimulation is a fundamental component of T cell biology and plays a ke..

Generating CAR T cells from tumor-infiltrating lymphocytes.

Jane K Mills, Melissa A Henderson, Lauren Giuffrida, Pasquale Petrone, Jennifer A Westwood, Phillip K Darcy, Paul J Neeson, Michael H Kershaw, David E Gyorki

2021-01-01

Background: Tumor-infiltrating lymphocytes (TILs) and chimeric antigen receptor (CAR) T-cell therapies have demonstrated promising..

Challenges and Opportunities for Effective Cancer Immunotherapies

Clare Y Slaney, Michael H Kershaw

2020-11-01

Using immunotherapy to treat cancers can be traced back to the 1890s, where a New York physician William Coley used heat-killed ba..

Chimeric antigen receptor T cell therapies for thoracic cancers-challenges and opportunities

Jack D Chan, Aaron J Harrison, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

2020-08-01

Cross-talk between tumors at anatomically distinct sites

Amanda J Oliver, Phillip K Darcy, Joseph A Trapani, Michael H Kershaw, Clare Y Slaney

2020-04-21

Cancer tissue is not homogenous, and individual metastases at different anatomical locations can differ from the primary tumor and..

Enhancing chimeric antigen receptor T-cell immunotherapy against cancer using a nanoemulsion-based vaccine targeting cross-presenting dendritic cells

Jack D Chan, Bianca von Scheidt, Bijun Zeng, Amanda J Oliver, Ashleigh S Davey, Aesha Ali, Ranjeny Thomas, Joseph A Trapani, Phillip K Darcy, Michael H Kershaw, Riccardo Dolcetti, Clare Y Slaney

2020-01-01

Objectives: Adoptive transfer of chimeric antigen receptor (CAR)-modified T cells is a form of cancer immunotherapy that has achie..

Enterotoxins can support CAR T cells against solid tumors

Bianca von Scheidt, Minyu Wang, Amanda J Oliver, Jack D Chan, Metta K Jana, Aesha I Ali, Fiona Clow, John D Fraser, Kylie M Quinn, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

2019-12-10

Responses of solid tumors to chimeric antigen receptor (CAR) T cell therapy are often minimal. This is potentially due to a lack o..

Genetic Redirection of T Cells for the Treatment of Pancreatic Cancer

Aesha I Ali, Amanda J Oliver, Tinaz Samiei, Jack D Chan, Michael H Kershaw, Clare Y Slaney

2019-02-12

Conventional treatments for pancreatic cancer are largely ineffective, and the prognosis for the vast majority of patients is poor..

CARs versus BiTEs: A Comparison between T Cell-Redirection Strategies for Cancer Treatment

Clare Y Slaney, Pin Wang, Phillip K Darcy, Michael H Kershaw

2018-08-01

The redirection of T cells against tumors holds much promise for the treatment of cancer. Two main approaches for T-cell redirecti..

Tissue-Dependent Tumor Microenvironments and Their impact on immunotherapy Responses

Amanda J Oliver, Peter KH Lau, Ashleigh S Unsworth, Sherene Loi, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

2018-01-31

Recent advances in cancer immunology have led to a better understanding of the role of the tumor microenvironment (TME) in tumor i..

An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy

Jennifer A Westwood, Sarah Ellis, Jill Danne, Chad Johnson, Viola Oorschot, Georg Ramm, David C Tscharke, Alexander J Davenport, James C Whisstock, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

2017-12-29

While immunotherapy employing chimeric antigen receptor (CAR) T cells can be effective against a variety of tumor types, little is..

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Clare Y Slaney, Bianca von Scheidt, Alexander J Davenport, Paul A Beavis, Jennifer A Westwood, Sherly Mardiana, David C Tscharke, Sarah Ellis, H Miles Prince, Joseph A Trapani, Ricky W Johnstone, Mark J Smyth, Michele W Teng, Aesha Ali, Zhiya Yu, Steven A Rosenberg, Nicholas P Restifo, Paul Neeson, Phillip K Darcy, Michael H Kershaw

2017-05-15

Purpose: While adoptive transfer of T cells bearing a chimeric antigen receptor (CAR) can eliminate substantial burdens of some le..

CAR T-cell therapy of solid tumors

Carmen SM Yong, Valerie Dardalhon, Christel Devaud, Naomi Taylor, Phillip K Darcy, Michael H Kershaw

2017-04-01

The potential for immunotherapy as a treatment option for cancer is clear from remarkable responses of some leukemia patients to a..

A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer

Carmen SM Yong, Liza B John, Christel Devaud, Miles H Prince, Ricky W Johnstone, Joseph A Trapani, Phillip K Darcy, Michael H Kershaw

2016-06-07

While adoptive immunotherapy using chimeric antigen receptor (CAR)-modified T cells can induce remission of some tumors, the role ..