A NEW HOST-PATHOGEN INTERACTION IN ARTHRITIS

Grant number: 1107001 | Funding period: 2016 - 2019

Completed

Abstract

This proposal aims to examine how the oral bacterial pathogen, P.gingivalis, interacts with the host to worsen the severity of disease in rheumatoid arthritis. We propose a new mechanism whereby the pathogen directly activates a major destructive host pathway to promote tissue and bone destruction, which are two of the clinical hallmarks of rheumatoid arthritis. We also propose that this host-pathogen interaction occurs in periodontal disease.

Related publications (2)

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

David P De Souza, Adrian Achuthan, Man KS Lee, Katrina J Binger, Ming-Chin Lee, Sophia Davidson, Dedreia L Tull, Malcolm J McConville, Andrew D Cook, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood

2019-10-01

Macrophage activation in response to LPS is coupled to profound metabolic changes, typified by accumulation of the TCA cycle inter..

Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles

Andrew J Fleetwood, Man KS Lee, William Singleton, Adrian Achuthan, Ming-Chin Lee, Neil M O'Brien-Simpson, Andrew D Cook, Andrew J Murphy, Stuart G Dashper, Eric C Reynolds, John A Hamilton

2017-08-04

Porphyromonas gingivalis is one of the bacterial species most closely associated with periodontitis and can shed large numbers of ..