HYPE OR HOPE? PLATELET-RICH PLASMA AS A SYMPTOM- AND DISEASE-MODIFYING TREATMENT FOR KNEE OSTEOARTHRITIS - THE RESTORE TRIAL
Grant number: 1106274 | Funding period: 2016 - 2020
Knee osteoarthritis (OA) is a major public health problem worldwide with no cure. Thus safe and effective treatments that reduce symptoms and slow structural disease progression are needed. This clinical trial aims to test the effects of injections of platelet-rich plasma (a blood product) into the knee on pain and joint structure in 288 people with knee OA. The results will provide high quality evidence to determine whether platelet rich plasma should be used to treat knee OA.
Related publications (3)
Reliability and Convergent Construct Validity of Quantitative Ultrasound for Synovitis, Meniscal Extrusion, and Osteophyte in Knee Osteoarthritis With MRI
Win Min Oo, James M Linklater, Kim L Bennell, Matthew S Daniel, Danielle Pryke, Xia Wang, Shirley P Yu, Leticia Deveza, Vicky Duong, David J Hunter
AIMS: To determine: 1) inter-rater reliability of quantitative measurements of ultrasound-detected synovitis, meniscal extrusion, ..
SUPERB MICROVASCULAR IMAGING IN LOW-GRADE INFLAMMATION OF KNEE OSTEOARTHRITIS COMPARED WITH POWER DOPPLER: CLINICAL, RADIOGRAPHIC AND MRI RELATIONSHIP
Win Min Oo, James M Linklater, Kim L Bennell, Shirley Yu, Kai Fu, Xia Wang, Vicky Duong, David J Hunter
We compared the assessment of active synovitis in knee osteoarthritis (OA) by utilising superb microvascular imaging (SMI) and con..
Efficacy of intra-articular injections of platelet-rich plasma as a symptom- and disease-modifying treatment for knee osteoarthritis - the RESTORE trial protocol
Kade L Paterson, David J Hunter, Ben R Metcalf, Jillian Eyles, Vicky Duong, Jessica Kazsa, Yuanyuan Wang, Rachelle Buchbinder, Flavia Cicuttini, Andrew Forbes, Anthony Harris, Shirley P Yu, Bing Hui Wang, David Connell, James Linklater, Kim L Bennell
BACKGROUND: Knee osteoarthritis (OA) causes substantial pain, physical dysfunction and impaired quality of life. There is no cure ..