DEFINING THE IMPACT OF UNIVERSAL IRON INTERVENTIONS IN YOUNG CHILDREN: A RANDOMIZED CONTROLLED TRIAL IN RURAL BANGLADESH

Grant number: 1103262 | Funding period: 2016 - 2022

Completed

Abstract

Although nearly half of the world's young children are anaemic, evidence regarding the best approaches to correct this problem are limited. New data even suggests that the conventional approaches (iron supplements, multiple micronutrient powders) may even be harmful. We will perform the definitive trial which will confirm the existence and magnitude of any benefit (and harm) from these interventions in young Bangladeshi children. This trial will inform global policy on anaemia control.

Related publications (10)

Scholarly works icon

Effects of iron supplementation on neural indices of habituation in Bangladeshi children.

Leila M Larson, Daniel Feuerriegel, Mohammed Imrul Hasan, Sabine Braat, Jerry Jin, Sm Mulk Uddin Tipu, Shamima Shiraji, Fahmida Tofail, Beverley-Ann Biggs, Jena D Hamadani, Katherine A Johnson, Stefan Bode, Sant-Rayn Pasricha

2023-01-01

BACKGROUND: Iron deficiency and anemia have been associated with poor cognition in children, yet the effects of iron supplementati..

Scholarly works icon

Supplementation With Iron Syrup or Iron-Containing Multiple Micronutrient Powders Alters Resting Brain Activity in Bangladeshi Children.

Leila M Larson, Daniel Feuerriegel, Mohammed Imrul Hasan, Sabine Braat, Jerry Jin, Sm Mulk Uddin Tipu, Shamima Shiraji, Fahmida Tofail, Beverley-Ann Biggs, Jena Hamadani, Katherine Johnson, Sant-Rayn Pasricha, Stefan Bode

2023-01-01

BACKGROUND: Anemia and iron deficiency have been associated with poor child cognitive development. A key rationale for the prevent..

Scholarly works icon

Cost-effectiveness of universal iron supplementation and iron-containing micronutrient powders for anemia among young children in rural Bangladesh: analysis of a randomized, placebo-controlled trial

Edifofon Akpan, Sheikh J Hossain, Angela Devine, Sabine Braat, Mohammed Hasan, SM Mulk Uddin Tipu, Mohammad Saiful Alam Bhuiyan, Jena D Hamadani, Beverley-Ann Biggs, Sant-Rayn Pasricha, Natalie Carvalho

2022-10-03

BACKGROUND: Universal provision of iron supplements or iron-containing multiple micronutrient powders (MNPs) is widely used to pre..

Scholarly works icon

Benefits and Risks of Iron Interventions in Infants in Rural Bangladesh

S-R Pasricha, M Hasan, S Braat, LM Larson, SMM-U Tipu, SJ Hossain, S Shiraji, A Baldi, MSA Bhuiyan, F Tofail, J Fisher, S Grantham-McGregor, JA Simpson, JD Hamadani, B-A Biggs

2021-09-09

BACKGROUND: Universal provision of iron supplements (drops or syrup) or multiple micronutrient powders to young children in low-to..

Scholarly works icon

Iron deficiency

Sant-Rayn Pasricha, Jason Tye-Din, Martina U Muckenthaler, Dorine W Swinkels

2021-01-14

Iron deficiency is one of the leading contributors to the global burden of disease, and particularly affects children, premenopaus..

Scholarly works icon

Preanalytic and analytic factors affecting the measurement of haemoglobin concentration: impact on global estimates of anaemia prevalence

Leila M Larson, Sabine Braat, Mohammed Imrul Hasan, Martin N Mwangi, Fernando Estepa, Sheikh Jamal Hossain, Danielle Clucas, Beverley-Ann Biggs, Kamija S Phiri, Jena Derakhshani Hamadani, Sant-Rayn Pasricha

2021-01-01

The accuracy of haemoglobin concentration measurements is crucial for deriving global anaemia prevalence estimates and monitoring ..

Scholarly works icon

Immediate impact of stay-at-home orders to control COVID-19 transmission on socioeconomic conditions, food insecurity, mental health, and intimate partner violence in Bangladeshi women and their families: an interrupted time series

Jena Derakhshani Hamadani, Mohammed Imrul Hasan, Andrew J Baldi, Sheikh Jamal Hossain, Shamima Shiraji, Mohammad Saiful Alam Bhuiyan, Syeda-Fardina Mehrin, Jane Fisher, Fahmida Tofail, SM Mulk Uddin Tipu, Sally Grantham-McGregor, Beverley-Ann Biggs, Sabine Braat, Sant-Rayn Pasricha

2020-11-01

BACKGROUND: Stay-at-home orders (lockdowns) have been deployed globally to control COVID-19 transmission, and might impair economi..

Scholarly works icon

Importance of Follow-up Studies to Examine Sustained Effects of Early Nutrition Interventions

Leila M Larson, Beverley-Ann Biggs

2020-03-01

Scholarly works icon

The Benefits and Risks of Iron interventionS in Children (BRISC) trial: Statistical analysis plan

Sabine Braat, Leila Larson, Julie A Simpson, Mohammed Imrul Hasan, Jena Derakhshani Hamadani, Sheikh Jamal Hossain, Shamima Shiraji, Mohammad Saiful Alam Bhuiyan, Beverley-Ann Biggs, Sant-Rayn Pasricha

2020-01-01

Background: The Benefits and Risks of Iron interventionS in Children (BRISC) trial will evaluate the impact of universal supplemen..

Scholarly works icon

Benefits and risks of Iron interventions in children (BRISC): protocol for a three-arm parallel-group randomised controlled field trial in Bangladesh

Mohammed Imrul Hasan, Sheikh Jamal Hossain, Sabine Braat, Michael John Dibley, Jane Fisher, Sally Grantham-McGregor, Fahmida Tofail, Julie A Simpson, Shams Ei Arifeen, Jena Hamadani, Beverley-Ann Biggs, Sant-Rayn Pasricha

2017-11-01

INTRODUCTION: Anaemia is a major global health problem affecting about 43% of preschool children globally and 60% of 6-24-month-ol..