CD4 MEMORY T-CELL DYNAMICS IN PERIPHERAL TISSUES
Grant number: 1103944 | Funding period: 2016 - 2019
The body’s surfaces are continually under threat from microbes that may cause debilitating disease. Our ability to control such infections relies on our immune system, consisting of different cell types with specialised functions. We will study frontline immune cells that populate barrier tissues such as skin and mucosa where they provide enhanced local protection by responding vigorously on infection. Our studies will guide the development of future therapies harnessing our immune system.
Related publications (2)
Comparative analysis reveals a role for TGF-beta in shaping the residency-related transcriptional signature in tissue-resident memory CD8( ) T cells
Artika P Nath, Asolina Braun, Scott C Ritchie, Francis R Carbone, Laura K Mackay, Thomas Gebhardt, Michael Inouye
Tissue-resident CD8+ memory T (TRM) cells are immune cells that permanently reside at tissue sites where they play an important ro..
Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance
Thomas Gebhardt, Umaimainthan Palendira, David C Tscharke, Sammy Bedoui
A large proportion of memory T cells disseminated throughout the body are non-recirculating cells whose maintenance and function i..