UNDERSTANDING THE NEUROBIOLOGY OF AUTISM SPECTRUM DISORDER
Grant number: 1098255 | Funding period: 2016 - 2020
Autism Spectrum Disorder (ASD) is a condition that causes difficulties with social interactions and communication, and unusual or intense behaviours. In most cases, the cause is unknown; however, there is evidence that the cause is likely genetic. We are using a new method to discover genes for ASD in families by looking at how features of ASD are inherited. Discovering genes for ASD will aid the development of new therapies and help parents of children with ASD with family planning.
Related publications (4)
Tracing Autism Traits in Large Multiplex Families to Identify Endophenotypes of the Broader Autism Phenotype
Krysta J Trevis, Natasha J Brown, Cherie C Green, Paul J Lockhart, Tarishi Desai, Tanya Vick, Vicki Anderson, Emmanuel PK Pua, Melanie Bahlo, Martin B Delatycki, Ingrid E Scheffer, Sarah J Wilson
Families comprising many individuals with Autism Spectrum Disorders (ASD) may carry a dominant predisposing mutation. We implement..
Cognitive Processes Predicting Advanced Theory of Mind in the Broader Autism Phenotype
Cherie C Green, Natasha J Brown, Valerie MZ Yap, Ingrid E Scheffer, Sarah J Wilson
Little is known about executive functions (EFs) associated with advanced theory of mind (ToM) abilities. We aimed to determine if ..
Generation of seven iPSC lines from peripheral blood mononuclear cells suitable to investigate Autism Spectrum Disorder
Kiymet Bozaoglu, Yujing Gao, Edouard Stanley, Miriam Fanjul-Fernandez, Natasha J Brown, Kate Pope, Cherie C Green, Katerina Vlahos, Koula Sourris, Melanie Bahlo, Martin Delatycki, Ingrid Scheffer, Paul J Lockhart
We have generated and characterized seven human induced pluripotent stem cell (iPSC) lines derived from peripheral blood mononucle..
Generation of iPSC lines from peripheral blood mononuclear cells from 5 healthy adults
Katerina Vlahos, Koula Sourris, Robyn Mayberry, Penelope McDonald, Freya F Bruveris, Jacqueline V Schiesser, Kiymet Bozaoglu, Paul J Lockhart, Edouard G Stanley, Andrew G Elefanty
We describe the generation and characterization of 5 human induced pluripotent stem cell (iPSC) lines derived from peripheral bloo..