UNDERSTANDING HOW VIRUS INFECTION ACCELERATES TYPE 1 DIABETES DEVELOPMENT
Grant number: 1103279 | Funding period: 2016 - 2018
We linked rotavirus infection in children at-risk of type 1 diabetes with faster diabetes development. A heightened response to the virus is implicated by our mouse model studies. We will determine if more rapid mouse diabetes due to rotavirus requires this heightened response, and if this response is also made by cells from diabetes patients after stimulation with rotavirus or other relevant viruses. These studies are vital to learn how viruses affect type 1 diabetes and devise interventions.
Related publications (1)
Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling
Jessica A Pane, Fiona E Fleming, Kate L Graham, Helen E Thomas, Thomas WH Kay, Barbara S Coulson
Rotavirus infection is associated with childhood progression to type 1 diabetes. Infection by monkey rotavirus RRV accelerates dia..