DECIPHERING THE ROLE OF SCRIBBLE IN DEVELOPMENT AND DISEASE
Grant number: 1103871 | Funding period: 2016 - 2016
Scribble is a protein that controls the orientation and organization of all cells within our body. Mutations in the Scribble gene are found in many cancers and also in some patients with spina bifida, however how these mutations cause these diseases is not understood. Here we propose experiments that can be used to link Scribble mutations to specific cellular functions. This information will help us design new therapies to treat diseases driven by tissue disorganization such as cancer.
Related publications (7)
Structural analysis of phosphorylation-associated interactions of human MCC with Scribble PDZ domains
Sofia Caria, Bryce Z Stewart, Ruitao Jin, Brian J Smith, Patrick O Humbert, Marc Kvansakul
Scribble is a crucial adaptor protein that plays a pivotal role during establishment and control of cell polarity, impacting many ..
The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis
Rebecca Stephens, Krystle Lim, Marta Portela, Marc Kvansakul, Patrick O Humbert, Helena E Richardson
The Scribble cell polarity module, comprising Scribbled (Scrib), Discs-large (Dlg) and Lethal-2-giant larvae (Lgl), has a tumor su..
Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large
Sofia Caria, Charlene M Magtoto, Tinaz Samiei, Marta Portela, Krystle YB Lim, Jing Yuan How, Bryce Z Stewart, Patrick O Humbert, Helena E Richardson, Marc Kvansakul
Epithelial cell polarity is controlled by components of the Scribble polarity module, and its regulation is critical for tissue ar..
Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor -PIX
Krystle YB Lim, Nathan J Goedde, Patrick O Humbert, Marc Kvansakul
Scribble is a highly conserved protein regulator of cell polarity that has been demonstrated to function as a tumor suppressor or,..
A Phenotypic High-Content Screening Assay to Identify Regulators of Membrane Protein Localization
Lorey K Smith, Daniel W Thomas, Kaylene J Simpson, Patrick O Humbert
Correct subcellular localization of proteins is a requirement for appropriate function. This is especially true in epithelial cell..