DECIPHERING THE ROLE OF SCRIBBLE IN DEVELOPMENT AND DISEASE

Grant number: 1103871 | Funding period: 2016 - 2016

Completed

Abstract

Scribble is a protein that controls the orientation and organization of all cells within our body. Mutations in the Scribble gene are found in many cancers and also in some patients with spina bifida, however how these mutations cause these diseases is not understood. Here we propose experiments that can be used to link Scribble mutations to specific cellular functions. This information will help us design new therapies to treat diseases driven by tissue disorganization such as cancer.

Related publications (7)

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Structural analysis of phosphorylation-associated interactions of human MCC with Scribble PDZ domains

Sofia Caria, Bryce Z Stewart, Ruitao Jin, Brian J Smith, Patrick O Humbert, Marc Kvansakul

2019-07-30

Scribble is a crucial adaptor protein that plays a pivotal role during establishment and control of cell polarity, impacting many ..

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Crystal structure of the human Scribble PDZ1 domain bound to the PDZ-binding motif of APC

Jing Yuan How, Sofia Caria, Patrick O Humbert, Marc Kvansakul

2019-03-01

Scribble (SCRIB) is an important adaptor protein that controls the establishment and maintenance of apico-basal cell polarity. To ..

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The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis

Rebecca Stephens, Krystle Lim, Marta Portela, Marc Kvansakul, Patrick O Humbert, Helena E Richardson

2018-09-28

The Scribble cell polarity module, comprising Scribbled (Scrib), Discs-large (Dlg) and Lethal-2-giant larvae (Lgl), has a tumor su..

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Regulation of cellular and PCP signalling by the Scribble polarity module

Michal Milgrom-Hoffman, Patrick O Humbert

2018-09-01

Since the first identification of the Scribble polarity module proteins as a new class of tumour suppressors that regulate both ce..

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Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large

Sofia Caria, Charlene M Magtoto, Tinaz Samiei, Marta Portela, Krystle YB Lim, Jing Yuan How, Bryce Z Stewart, Patrick O Humbert, Helena E Richardson, Marc Kvansakul

2018-03-23

Epithelial cell polarity is controlled by components of the Scribble polarity module, and its regulation is critical for tissue ar..

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Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor -PIX

Krystle YB Lim, Nathan J Goedde, Patrick O Humbert, Marc Kvansakul

2017-12-15

Scribble is a highly conserved protein regulator of cell polarity that has been demonstrated to function as a tumor suppressor or,..

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A Phenotypic High-Content Screening Assay to Identify Regulators of Membrane Protein Localization

Lorey K Smith, Daniel W Thomas, Kaylene J Simpson, Patrick O Humbert

2016-10-01

Correct subcellular localization of proteins is a requirement for appropriate function. This is especially true in epithelial cell..