ROLE OF MICROBIOTA IN THE DEVELOPING ENTERIC NERVOUS SYSTEM
Grant number: 1099016 | Funding period: 2016 - 2019
The correct development of neurons in the gut is vital for digestive functions. This project will provide novel insights into how environmental factors such as the bacteria that reside in the gut and changes in diet affect maturation of the gut’s nervous system. The data will improve knowledge of the effects of widely used antibiotics and probiotics, which will facilitate strategies to improve human health and quality of life.
Related publications (6)
Antibiotic exposure postweaning disrupts the neurochemistry and function of enteric neurons mediating colonic motor activity
Lin Y Hung, Pavitha Parathan, Prapaporn Boonma, Qinglong Wu, Yi Wang, Anthony Haag, Ruth Ann Luna, Joel C Bornstein, Tor C Savidge, Jaime PP Foong
The period during and immediately after weaning is an important developmental window when marked shifts in gut microbiota can regu..
The enteric nervous system undergoes significant chemical and synaptic maturation during adolescence in mice
Pavitha Parathan, Yi Wang, Anita JL Leembruggen, Joel C Bornstein, Jaime PP Foong
Adolescence is a critical period of development. It is very likely that there is significant maturation of the enteric nervous sys..
alpha-Synuclein Regulates Development and Function of Cholinergic Enteric Neurons in the Mouse Colon
M Swaminathan, C Fung, D Finkelstein, JC Bornstein, JPP Foong
Alpha-Synuclein (α-Syn) is expressed in the central nervous system and the nervous system of the gut (enteric nervous system, ENS)..
Cholinergic Submucosal Neurons Display Increased Excitability Following in Vivo Cholera Toxin Exposure in Mouse Ileum
Candice Fung, Katerina Koussoulas, Petra Unterweger, Andrew M Allen, Joel C Bornstein, Jaime PP Foong
Cholera-induced hypersecretion causes dehydration and death if untreated. Cholera toxin (CT) partly acts via the enteric nervous s..