NEXT GENERATION CYBERNETICS: LONG TERM CARBON FIBRE DUAL STIMULATION / RECORDING ELECTRODE ARRAYS FOR CLOSED LOOP NEURAL IMPLANTS
Grant number: 1101717 | Funding period: 2016 - 2021
Electrodes implanted in the brain have enormous potential for treating a range of conditions from epilepsy to control of prosthetics for patients with limb loss. Currently, the electrodes used in such system fail rapidly because they are rejected by the body. We aim to use diamond with ultra-fine carbon fibre electrodes to make arrays that are invisible to the human immune system. Such arrays will function for the lifetime of the patient without needing replacement.
Related publications (37)
Laminin coated diamond electrodes for neural stimulation
Md Kabir Uddin Sikder, Wei Tong, Hitesh Pingle, Peter Kingshott, Karina Needham, Mohit N Shivdasani, James B Fallon, Peter Seligman, Michael R Ibbotson, Steven Prawer, David J Garrett
The performance of many implantable neural stimulation devices is degraded due to the loss of neurons around the electrodes by the..
Improved wetting of gold active braze alloy on diamond for use in medical implants
K Edalati, M Stamp, K Ganesan, A Stacey, G Martin-Hardy, R Fontaine, S Prawer, DJ Garrett
Medical implants containing active electronics must have a leak-proof encapsulation to be certified as safe for human use. Implant..
High Fidelity Bidirectional Neural Interfacing with Carbon Fiber Microelectrodes Coated with Boron-Doped Carbon Nanowalls: An Acute Study
Maryam A Hejazi, Wei Tong, Alastair Stacey, Shi H Sun, Molis Yunzab, Ali Almasi, Young Jun Jung, Hamish Meffin, Kate Fox, Khatereh Edalati, Athavan Nadarajah, Steven Prawer, Michael R Ibbotson, David J Garrett
Implantable electrodes that can communicate with a small, selective group of neurons via both neural stimulation and recording are..
Minimizing axon bundle activation of retinal ganglion cells with oriented rectangular electrodes.
Wei Tong, Maryam Hejazi, David J Garrett, Timothy Esler, Steven Prawer, Hamish Meffin, Michael Ibbotson
OBJECTIVE: Retinal prostheses aim to restore vision in patients with retinal degenerative diseases, such as age-related macular de..
Near-infrared excitation of nitrogen-doped ultrananocrystalline diamond photoelectrodes in saline solution
Andre Chambers, Arman Ahnood, Samira Falahatdoost, Steve Yianni, David Hoxley, Brett C Johnson, David J Garrett, Snjezana Tomljenovic-Hanic, Steven Prawer
Nitrogen-doped ultrananocrystalline diamond (N-UNCD) is a promising material for a variety of neural interfacing applications, due..
Hybrid diamond/ carbon fiber microelectrodes enable multimodal electrical/chemical neural interfacing
Maryam A Hejazi, Wei Tong, Alastair Stacey, Artemio Soto-Breceda, Michael R Ibbotson, Molis Yunzab, Matias I Maturana, Ali Almasi, Young Jun Jung, Shi Sun, Hamish Meffin, Jian Fang, Melanie EM Stamp, Kumaravelu Ganesan, Kate Fox, Aaqil Rifai, Athavan Nadarajah, Samira Falahatdoost, Steven Prawer, Nicholas V Apollo
Implantable medical devices are now in regular use to treat or ameliorate medical conditions, including movement disorders, chroni..
Improved visual acuity using a retinal implant and an optimized stimulation strategy
Wei Tong, Melanie Stamp, Nicholas Apollo, Kumaravelu Ganesan, Hamish Meffin, Steven Prawer, David J Garrett, Michael R Ibbotson
Objective. Retinal prosthetic devices hold great promise for the treatment of retinal degenerative diseases such as retinitis pigm..
Wide dipole antennas for wireless powering of miniaturised bioelectronic devices
A Aldaoud, S Lui, KS Keng, S Moshfegh, A Soto-Breceda, W Tong, JM Redoute, DJ Garrett, YT Wong, S Prawer
Biomedical electronic implants require a power source to operate. Miniaturised implants can preclude batteries and as implant dime..
Electrically conducting diamond films grown on platinum foil for neural stimulation
Md Kabir Uddin Sikder, Mohit N Shivdasani, James B Fallon, Peter Seligman, Kumaravelu Ganesan, Joel Villalobos, Steven Prawer, David J Garrett
OBJECTIVE: With the strong drive towards miniaturization of active implantable medical devices and the need to improve the resolut..
Wireless multichannel optogenetic stimulators enabled by narrow bandwidth resonant tank circuits
Ammar Aldaoud, Artemio Soto-Breceda, Wei Tong, Greg Conductier, Mary A Tonta, Harold A Coleman, Helena C Parkington, Iain Clarke, Jean-Michel Redoute, David J Garrett, Steven Prawer
Optogenetic neuromodulation is a powerful technique used to study cells that form part of neuronal circuits. Light stimulation of ..
Electrical receptive fields of retinal ganglion cells: Influence of presynaptic neurons
Matias I Maturana, Nicholas V Apollo, David J Garrett, Tatiana Kameneva, Shaun L Cloherty, David B Grayden, Anthony N Burkitt, Michael R Ibbotson, Hamish Meffin
Implantable retinal stimulators activate surviving neurons to restore a sense of vision in people who have lost their photorecepto..
Wireless induction coils embedded in diamond for power transfer in medical implants
Md Kabir Uddin Sikder, James Fallon, Mohit N Shivdasani, Kumaravelu Ganesan, Peter Seligman, David J Garrett
Wireless power and data transfer to medical implants is a research area where improvements in current state-of-the-art technologie..
Neural Responses to Multielectrode Stimulation of Healthy and Degenerate Retina
Kerry J Halupka, Carla J Abbott, Yan T Wong, Shaun L Cloherty, David B Grayden, Anthony N Burkitt, Evgeni N Sergeev, Chi D Luu, Alice Brandli, Penelope J Allen, Hamish Meffin, Mohit N Shivdasani
Purpose: Simultaneous stimulation of multiple retinal electrodes in normally sighted animals shows promise in improving the resolu..
Diamond Devices for High Acuity Prosthetic Vision
Arman Ahnood, Hamish Meffin, David J Garrett, Kate Fox, Kumaravelu Ganesan, Alastair Stacey, Nicholas V Apollo, Yan T Wong, Samantha G Lichter, William Kentler, Omid Kavehei, Ursula Greferath, Kirstan A Vessey, Michael R Ibbotson, Erica L Fletcher, Anthony N Burkitt, Steven Prawer
Retinal implants restore a sense of vision, for a growing number of users worldwide. Nevertheless, visual acuities provided by the..
Prediction of cortical responses to simultaneous electrical stimulation of the retina
Kerry J Halupka, Mohit N Shivdasani, Shaun L Cloherty, David B Grayden, Yan T Wong, Anthony N Burkitt, Hamish Meffin
OBJECTIVE: Simultaneous electrical stimulation of multiple electrodes has shown promise in diversifying the responses that can be ..
Brazing techniques for the fabrication of biocompatible carbon-based electronic devices
Nicholas V Apollo, Desmond Lau, Arman Ahnood, Alastair Stacey, Kumaravelu Ganesan, Samantha G Lichter, Kate Fox, Javad Foroughi, Hamish Meffin, Gordon G Wallace, Ray Baughman, Steven Prawer, David J Garrett
Prototype electronic devices have been critical to the discovery and demonstration of the unique properties of new materials, incl..
Optimizing growth and post treatment of diamond for high capacitance neural interfaces
Wei Tong, Kate Fox, Akram Zamani, Ann M Turnley, Kumaravelu Ganesan, Arman Ahnood, Rosemary Cicione, Hamish Meffin, Steven Prawer, Alastair Stacey, David J Garrett
Electrochemical and biological properties are two crucial criteria in the selection of the materials to be used as electrodes for ..
Spectral distribution of local field potential responses to electrical stimulation of the retina
Yan T Wong, Kerry Halupka, Tatiana Kameneva, Shaun L Cloherty, David B Grayden, Anthony N Burkitt, Hamish Meffin, Mohit N Shivdasani
OBJECTIVE: Different frequency bands of the local field potential (LFP) have been shown to reflect neuronal activity occurring at ..
A Simple and Accurate Model to Predict Responses to Multi-electrode Stimulation in the Retina
Matias I Maturana, Nicholas V Apollo, Alex E Hadjinicolaou, David J Garrett, Shaun L Cloherty, Tatiana Kameneva, David B Grayden, Michael R Ibbotson, Hamish Meffin
Implantable electrode arrays are widely used in therapeutic stimulation of the nervous system (e.g. cochlear, retinal, and cortica..
Development of a Magnetic Attachment Method for Bionic Eye Applications
Kate Fox, Hamish Meffin, Owen Burns, Carla J Abbott, Penelope J Allen, Nicholas L Opie, Ceara McGowan, Jonathan Yeoh, Arman Ahnood, Chi D Luu, Rosemary Cicione, Alexia L Saunders, Michelle McPhedran, Lisa Cardamone, Joel Villalobos, David J Garrett, David AX Nayagam, Nicholas V Apollo, Kumaravelu Ganesan, Mohit N Shivdasani
Successful visual prostheses require stable, long-term attachment. Epiretinal prostheses, in particular, require attachment method..
Retinal ganglion cells: mechanisms underlying depolarization block and differential responses to high frequency electrical stimulation of ON and OFF cells
T Kameneva, MI Maturana, AE Hadjinicolaou, SL Cloherty, MR Ibbotson, DB Grayden, AN Burkitt, H Meffin
OBJECTIVE: ON and OFF retinal ganglion cells (RGCs) are known to have non-monotonic responses to increasing amplitudes of high fre..
A computational model of orientation-dependent activation of retinal ganglion cells
Timothy Esler, Anthony N Burkitt, David B Grayden, Robert R Kerr, Bahman Tahayori, Hamish Meffin
Currently, a challenge in electrical stimulation for epiretinal prostheses is the avoidance of stimulation of axons of passage in ..
In vivo biocompatibility of boron doped and nitrogen included conductive-diamond for use in medical implants
David J Garrett, Alexia L Saunders, Ceara McGowan, Joscha Specks, Kumaravelu Ganesan, Hamish Meffin, Richard A Williams, David AX Nayagam
Recently, there has been interest in investigating diamond as a material for use in biomedical implants. Diamond can be rendered e..
Prosthetic vision: devices, patient outcomes and retinal research
Alex E Hadjinicolaou, Hamish Meffin, Matias I Maturana, Shaun L Cloherty, Michael R Ibbotson
Retinal disease and its associated retinal degeneration can lead to the loss of photoreceptors and therefore, profound blindness. ..
Hermetic diamond capsules for biomedical implants enabled by gold active braze alloys
Samantha G Lichter, Mathilde C Escudie, Alastair D Stacey, Kumaravelu Ganesan, Kate Fox, Arman Ahnood, Nicholas V Apollo, Dunstan C Kua, Aaron Z Lee, Ceara McGowan, Alexia L Saunders, Owen Burns, David AX Nayagam, Richard A Williams, David J Garrett, Hamish Meffin, Steven Prawer
As the field of biomedical implants matures the functionality of implants is rapidly increasing. In the field of neural prostheses..
Ultrananocrystalline diamond-CMOS device integration route for high acuity retinal prostheses
A Ahnood, MC Escudie, R Cicione, CD Abeyrathne, K Ganesan, KE Fox, DJ Garrett, A Stacey, NV Apollo, SG Lichter, CDL Thomas, N Tran, H Meffin, S Prawer
High density electrodes are a new frontier for biomedical implants. Increasing the density and the number of electrodes used for t..
Broadband Onset Inhibition Can Suppress Spectral Splatter in the Auditory Brainstem
Martin J Spencer, David AX Nayagam, Janine C Clarey, Antonio G Paolini, Hamish Meffin, Anthony N Burkitt, David B Grayden
In vivo intracellular responses to auditory stimuli revealed that, in a particular population of cells of the ventral nucleus of t..
The effects of temperature changes on retinal ganglion cell responses to electrical stimulation
MI Maturana, NV Apollo, DJ Garrett, T Kameneva, H Meffin, MR Ibbotson, SL Cloherty, D GRAYDEN
Little is known about how the retina's response to electrical stimulation is modified by temperatures. In vitro experiments are of..
Fabrication of planarised conductively patterned diamond for bio-applications
Wei Tong, Kate Fox, Kumaravelu Ganesan, Ann M Turnley, Olga Shimoni, Phong A Tran, Alexander Lohrmann, Thomas McFarlane, Arman Ahnood, David J Garrett, Hamish Meffin, Neil M O'Brien-Simpson, Eric C Reynolds, Steven Prawer
The development of smooth, featureless surfaces for biomedical microelectronics is a challenging feat. Other than the traditional ..