DETERMINING THE CONTRIBUTION OF OREXIN RECEPTOR SUBTYPES TO SLEEP ARCHITECTURE
Grant number: 1105284 | Funding period: 2016 - 2019
Sleep is an essential process that follows a regular pattern every night. The brain orexin system is a promising new target for sleep-inducing drugs; however it is not clear how best to manipulate this system to reproduce the cycles of sleep necessary to receive all the benefits sleep has to offer. This project will elucidate the contribution of the different components of the orexin system to the characteristics of sleep. This will facilitate the development of better treatments for insomnia.
Related publications (13)
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Sleep is a complex biological state characterized by large populations of neurons firing in a rhythmic or synchronized manner. HCN..
Development of a LC-ESI-MRM method for the absolute quantification of orexin A in the CSF of individual mice
K Hopkins, S Mukherjee, D Ponce, J Mangum, LH Jacobson, D Hoyer
Sleep-wakefulness is disrupted in most neurological and psychiatric disorders. Although clinical data implicate orexin (hypocretin..
Reward Motivation and Cognitive Flexibility in Tau Null-Mutation Mice
Sara Oberrauch, Jeremy A Metha, Maddison L Brian, Samuel A Barnes, Travis J Featherby, Andrew J Lawrence, Daniel Hoyer, Carsten Murawski, Laura H Jacobson
The reduction of tau or hyperphosphorylated tau (p-tau) has been proposed as a therapeutic strategy for Alzheimer's disease (AD) a..
Manipulation of rapid eye movement sleep via orexin and GABA(A) receptor modulators differentially affects fear extinction in mice: effect of stable versus disrupted circadian rhythm
Jacob W Clark, Heather Daykin, Jeremy A Metha, Giancarlo Allocca, Daniel Hoyer, Sean PA Drummond, Laura H Jacobson
Sleep disruption, and especially rapid eye movement (REM) sleep disruption, is associated with fear inhibition impairment in anima..
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function
Nicholas M Barnes, Gerard P Ahern, Carine Becamel, Joel Bockaert, Michael Camilleri, Severine Chaumont-Dubel, Sylvie Claeysen, Kathryn A Cunningham, Kevin C Fone, Michael Gershon, Giuseppe Di Giovanni, Nathalie M Goodfellow, Adam L Halberstadt, Rachel M Hartley, Gherici Hassaine, Katharine Herrick-Davis, Ruud Hovius, Enza Lacivita, Evelyn K Lambe, Marcello Leopoldo
5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Thei..
Effects of orexin receptor antagonism on human sleep architecture: A systematic review
Jacob W Clark, Maddison L Brian, Sean PA Drummond, Daniel Hoyer, Laura H Jacobson
Orexin receptor antagonists are a relatively new hypnotic principle. Their influence on human sleep architecture is a point of deb..
Circadian disruption impairs fear extinction and memory of conditioned safety in mice
Jacob W Clark, Daniel Hoyer, Sean W Cain, Andrew Phillips, Sean PA Drummond, Laura H Jacobson
Animal models of fear conditioning and fear inhibition are frequently employed in the study of associative learning and commonly d..
Separating Probability and Reversal Learning in a Novel Probabilistic Reversal Learning Task for Mice
Jeremy A Metha, Maddison L Brian, Sara Oberrauch, Samuel A Barnes, Travis J Featherby, Peter Bossaerts, Carsten Murawski, Daniel Hoyer, Laura H Jacobson
The exploration/exploitation tradeoff – pursuing a known reward vs. sampling from lesser known options in the hope of finding a be..
Sex differences in mouse models of fear inhibition: Fear extinction, safety learning, and fear-safety discrimination
Jacob W Clark, Sean PA Drummond, Daniel Hoyer, Laura H Jacobson
BACKGROUND AND PURPOSE: Women are overrepresented in post-traumatic stress disorder (PTSD), a mental disorder characterised by ine..
The social defeat/overcrowding murine psychosocial stress model results in a pharmacologically reversible body weight gain but not depression - related behaviours
Ryan J Keenan, Jacky Chan, Paul S Donnelly, Kevin J Barnham, Laura H Jacobson
Depression is a highly prevalent psychiatric disorder, yet its etiology is not well understood. The validation of animal models is..