TRACKING THE ORIGINS AND DRIVERS OF METASTASIS IN PROSTATE CANCER
Grant number: 1104010 | Funding period: 2016 - 2019
Prostate cancer is now the most commonly diagnosed cancer but only 10% of men with it, will die from it. Our current ability to discriminate between cancers with an indolent course and those that are lethal is poor. This project will examine the mixture of tumour clones (subclones) that are present in prostate cancers and define and track those cancer subclones that break away from the prostate and lodge in distant sites, causing death.
Related publications (2)
Inferring structural variant cancer cell fraction
Marek Cmero, Ke Yuan, Cheng Soon Ong, Jan Schröder, null PCAWG Evolution and Heterogeneity Working Group, Niall M Corcoran, Tony Papenfuss, Christopher M Hovens, Florian Markowetz, Geoff Macintyre, null PCAWG Consortium
We present SVclone, a computational method for inferring the cancer cell fraction of structural variant (SV) breakpoints from whol..