ANTIBODY PREVENTION AND TREATMENT OF HIV

Grant number: 1101813 | Funding period: 2016 - 2019

Completed

Abstract

This project will assess new ways to protect against HIV infection and treat HIV infection using potent antibody therapies. This will help us understand how the immune system can control HIV. We will generate antibody fragments that can be produced relatively cheaply that, if successful, could lead to a viable antibody therapy for HIV.

Related publications (4)

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Fc-dependent functions are redundant to efficacy of anti-HIV antibody PGT121 in macaques

Matthew S Parsons, Wen Shi Lee, Anne B Kristensen, Thakshila Amarasena, Georges Khoury, Adam K Wheatley, Arnold Reynaldi, Bruce D Wines, P Mark Hogarth, Miles P Davenport, Stephen J Kent

2019-01-02

A considerable body of evidence suggests that Fc-dependent functions improve the capacity of broadly neutralizing antibodies (BnAb..

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Neutralizing Antibody-Based Prevention of Cell-Associated HIV-1 Infection

Matthew S Parsons, Roger Le Grand, Stephen J Kent

2018-06-01

Improved vaccine-mediated protection against HIV-1 requires a thorough understanding of the mode of HIV-1 transmission and how var..

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Partial Efficacy of a Broadly Neutralizing Antibody against Cell-associated SHIV Infection

Matthew Parsons, Sarah Lloyd, Robert Center, Katherine Swiderek, Celia LaBranche, David Montefiori, Brandon Keele, Jeffrey Lifson, Vanessa Venturi, Miles Davenport, Thakshila Amarasena, Stephen Kent

2016-10-01

Broadly neutralizing antibodies (BnAbs) protect macaques from cell-free simian/human immunodeficiency virus (SHIV) challenge, but ..

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Seminal Plasma Anti-HIV Antibodies Trigger Antibody-dependent Cellular Cytotoxicity: Implications for HIV Transmission

Matthew S Parsons, Vijaya Madhavi, Fernanda Ana-Sosa-Batiz, Rob J Center, Kim M Wilson, Torsak Bunupuradah, Kiat Ruxrungtham, Stephen J Kent

2016-01-01

Recent evidence from HIV vaccine trials in humans and non-human primates suggests that nonneutralizing antibody functions, such as..

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