Technetium and Copper Complexes for Diagnostic Imaging of Neurodegeneration
Grant number: DP160100288 | Funding period: 2016 - 2019
This project aims to develop new synthetic coordination chemistry for making metal complexes to assist in the diagnosis of neurodegeneration. The focus will be on the design and synthesis of new copper and technetium complexes designed to have the desirable properties to be of use as tracers for molecular imaging. The project aims to lead to fundamental advances in inorganic chemistry and the synthesis of metal complexes designed for biological applications.
Related publications (10)
Oxorhenium(V) and Oxotechnetium(V) Complexes of N3S Tetradentate Ligands with a Styrylpyridyl Functional Group: Toward Imaging Agents to Assist in the Diagnosis of Alzheimer's Disease
Benjamin Spyrou, Ingebjorg N Hungnes, Filipa Mota, Jayanta Bordoloi, Philip J Blower, Jonathan M White, Michelle T Ma, Paul S Donnelly
Alzheimer's disease (AD) is associated with the presence of amyloid plaques in the brain mainly comprised of aggregated forms of a..
Copper Bis(thiosemicarbazonato)-stilbenyl Complexes That Bind to Amyloid-beta Plaques
Asif Noor, David J Hayne, SinChun Lim, Jessica K Van Zuylekom, Carleen Cullinane, Peter D Roselt, Catriona A McLean, Jonathan M White, Paul S Donnelly
Alzheimer's disease is characterized by the presence of extracellular amyloid-β plaques. Positron emission tomography (PET) imagin..
Modification of Biodistribution and Brain Uptake of Copper Bis(thiosemicarbazonato) Complexes by the Incorporation of Amine and Polyamine Functional Groups
Brett M Paterson, Carleen Cullinane, Peter J Crouch, Anthony R White, Kevin J Barnham, Peter D Roselt, Wayne Noonan, David Binns, Rodney J Hicks, Paul S Donnelly
The synthesis of new bis(thiosemicarbazonato)copper(II) complexes featuring polyamine substituents via selective transamination re..
Potential Diagnostic Imaging of Alzheimer's Disease with Copper-64 Complexes That Bind to Amyloid-beta Plaques
Lachlan E McInnes, Asif Noor, Kai Kysenius, Carleen Cullinane, Peter Roselt, Catriona A McLean, Francis CK Chiu, Andrew K Powell, Peter J Crouch, Jonathan M White, Paul S Donnelly
Amyloid-β plaques, consisting of aggregated amyloid-β peptides, are one of the pathological hallmarks of Alzheimer's disease. Copp..
Rhenium and technetium complexes of thioamide derivatives of pyridylhydrazine that bind to amyloid-beta plaques
Scott P Fletcher, Asif Noor, James L Hickey, Catriona A McLean, Jonathan M White, Paul S Donnelly
Age-associated deposition of amyloid-β in cerebral blood vessels, a condition referred to as cerebral amyloid angiopathy, can cont..
Effect of Structural Modifications to Glyoxal-bis(thiosemicarbazonato)copper(II) Complexes on Cellular Copper Uptake, Copper-Mediated ATP7A Trafficking, and P-Glycoprotein Mediated Efflux
Karla M Acevedo, David J Hayne, Lachlan E McInnes, Asif Noor, Clare Duncan, Diane Moujalled, Irene Volitakis, Angela Rigopoulos, Kevin J Barnham, Victor L Villemagne, Anthony R White, Paul S Donnelly
Bis(thiosemicarbazonato)copper(II) complexes are of interest as potential therapeutics for cancer and neurodegenerative diseases a..
Guest-induced Assembly of Bis(thiosemicarbazonato) Zinc(II) Coordination Nanotubes
Brett M Paterson, Keith F White, Jonathan M White, Brendan F Abrahams, Paul S Donnelly
A ZnII complex of the dianionic tetradentate ligand formed by deprotonation of glyoxal‐bis(4‐phenyl‐3‐thiosemicarbazone) (H2gtsp) ..
The efficient synthesis and purification of amyloid-beta(1-42) using an oligoethylene glycol-containing photocleavable lysine tag
John A Karas, Asif Noor, Christine Schieber, Timothy U Connell, Frances Separovic, Paul S Donnelly
A short, monodisperse oligoethylene glycol-containing photocleavable lysine tag was developed to facilitate the efficient purifica..
A one-pot route to thioamides discovered by gas-phase studies: palladium-mediated CO2 extrusion followed by insertion of isothiocyanates
Asif Noor, Jiawei Li, George N Khairallah, Zhen Li, Hossein Ghari, Allan J Canty, Alireza Ariafard, Paul S Donnelly, Richard AJ O'Hair
A new palladium mediated “one pot” synthesis of thioamides from aromatic carboxylic acids (ArCO2H + RNCS → ArC(S)NHR + CO2) was di..