Understanding the physiological changes accompanying arousal from sleep

Grant number: DP160101398 | Funding period: 2016 - 2019

Completed

Abstract

This project aims to investigate neural memory in upper airway dilator muscles. Following brief awakening from sleep (arousal), upper airway dilator muscle activity is elevated for 20–30 seconds despite inhibitory stimuli being present. The cause for the elevated activity is unknown. This project aims to investigate whether a form of neural memory contributes to the elevated activity. It expects to demonstrate that arousal can induce a neural memory that is not inhibited by usual stimuli. The findings are expected to increase our understanding of normal human functioning but may also have implications for conditions where upper airway muscles are important such as dysphagia, sleep apnea and ..

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University of Melbourne Researchers