Understanding the physiological changes accompanying arousal from sleep
Grant number: DP160101398 | Funding period: 2016 - 2019
This project aims to investigate neural memory in upper airway dilator muscles. Following brief awakening from sleep (arousal), upper airway dilator muscle activity is elevated for 20–30 seconds despite inhibitory stimuli being present. The cause for the elevated activity is unknown. This project aims to investigate whether a form of neural memory contributes to the elevated activity. It expects to demonstrate that arousal can induce a neural memory that is not inhibited by usual stimuli. The findings are expected to increase our understanding of normal human functioning but may also have implications for conditions where upper airway muscles are important such as dysphagia, sleep apnea and ..View full description
Related publications (2)
After-discharge in the upper airway muscle genioglossus following brief hypoxia
Joanne Avraam, Andrew Dawson, Nicole Feast, Feiven Lee Fan, Monika D Fridgant, Amanda Kay, Zi Yi Koay, Pingdong Jia, Rachel Greig, Therese Thornton, Christian L Nicholas, Fergal J O'Donoghue, John Trinder, Amy S Jordan
STUDY OBJECTIVES: Genioglossus (GG) after-discharge is thought to protect against pharyngeal collapse by minimizing periods of low..
The Influence of CO2 on Genioglossus Muscle After-Discharge Following Arousal From Sleep
Jennifer M Cori, Peter D Rochford, Fergal J O'Donoghue, John Trinder, Amy S Jordan
Objectives: Ventilatory after-discharge (sustained elevation of ventilation following stimulus removal) occurs during sleep but no..