Shape-Shifting Molecules: Photoisomerization Action Spectroscopy
Grant number: DP160100474 | Funding period: 2016 - 2022
This project aims to examine molecules that change shape in response to light in order to gain insight into the biological processes they control. Many biological systems, including the human visual apparatus and bacterial photosynthesis, depend on molecules that change shape in response to light. The project plans to probe shape-shifting molecules with laser light while they are propelled through gas by an electric field. Light-induced changes in molecular shape produce detectable variations in drift speed. The ensuing knowledge would help calibrate computational approaches for predicting molecular function. It would also establish foundations for understanding essential biological molecule..View full description
Related publications (33)
Photophysics of Isolated Rose Bengal Anions
Mark H Stockett, Christina Kjaer, Steven Daly, Evan J Bieske, Jan RR Verlet, Steen Brondsted Nielsen, James N Bull
Dye molecules based on the xanthene moiety are widely used as fluorescent probes in bioimaging and technological applications due ..
Photo- and Collision-Induced Isomerization of a Charge-Tagged Norbornadiene-Quadricyclane System
Ugo Jacovella, Eduardo Carrascosa, Jack T Buntine, Nicolai Ree, Kurt Mikkelsen, Martyn Jevric, Kasper Moth-Poulsen, Evan J Bieske
Molecular photoswitches based on the norbornadiene–quadricylane (NBD–QC) couple have been proposed as key elements of molecular so..
N-3( ): Full-dimensional ground state potential energy surface, vibrational energy levels, and dynamics
Debasish Koner, Max Schwilk, Sarbani Patra, Evan J Bieske, Markus Meuwly
The fundamental vibrational frequencies and higher vibrationally excited states for the N+3 ion in its electronic ground state hav..
Electronic Spectrum and Photodissociation Chemistry of the 1-Butyn-3-y1 Cation, H3CCHCCFI
Giel Muller, Ugo Jacovella, Katherine J Catani, Gabriel da Silva, Evan J Bieske
The B̃1A' ← X̃1A' electronic spectra of the 1-butyn-3-yl cation (H3CCHCCH+) and the H3CCHCCH+-Ne and H3CCHCCH+-Ar complexes are me..
Near-infrared reversible photoswitching of an isolated azobenzene-stilbene dye
Eduardo Carrascosa, James N Bull, Jack T Buntine, Gabriel da Silva, Paulo F Santos, Evan J Bieske
Photoswitching of a charged azobenzene-stilbene dye is investigated through laser excitation in a tandem ion mobility mass spectro..
Reversible Photoswitching of Isolated Ionic Hemiindigos with Visible Light
Eduardo Carrascosa, Christian Petermayer, Michael S Scholz, James N Bull, Henry Dube, Evan J Bieske
Indigoid chromophores have emerged as versatile molecular photoswitches, offering efficient reversible photoisomerization upon exp..
Structural characterization and gas-phase studies of the [Ag10H8(L)(6)](2 ) nanocluster dication
Howard Z Ma, Alasdair McKay, Antonia Mravak, Michael S Scholz, Jonathan M White, Roger J Mulder, Evan J Bieske, Vlasta Bonacic-Koutecky, Richard AJ O'Hair
The reactions between silver salts and borohydrides produce a rich set of products that range from discrete mononuclear compounds ..
Electronic Spectra of Diacetylene Cations (HC4H ) Tagged with Ar and N-2
Giel Muller, Katherine J Catani, Michael S Scholz, Ugo Jacovella, Nastasia Bartlett, Evan J Bieske
Electronic spectra of mass-selected HC4H+-Arn (n = 1-3) and HC4H+-(N2)n (n = 1-2) complexes are measured over the 290-530 nm range..
Photodetachment and photoreactions of substituted naphthalene anions in a tandem ion mobility spectrometer
James N Bull, Jack T Buntine, Michael S Scholz, Eduardo Carrascosa, Linda Giacomozzi, Mark H Stockett, Evan J Bieske
Substituted naphthalene anions (deprotonated 2-naphthol and 6-hydroxy-2-naphthoic acid) are spectroscopically probed in a tandem d..
Photoinitiated Intramolecular Proton Transfer in Deprotonated para-Coumaric Acid
James N Bull, Gabriel da Silva, Michael S Scholz, Eduardo Carrascosa, Evan J Bieske
Deprotonated para-coumaric acid is commonly considered as a model for the chromophore in photoactive yellow protein, which undergo..
Electronic Spectra of the Triacetylene Cation (HC6H ) and Protonated Triacetylene (HC6H2 ) Tagged with Ar
Ugo Jacovella, Giel Muller, Katherine J Catani, Nastasia I Bartlett, Evan J Bieske
Polyacetylene cations (HC 2n H + ) play important roles in combustion processes and in the chemistry of planetary atmospheres and ..
Ion mobility action spectroscopy of flavin dianions reveals deprotomer-dependent photochemistry
James N Bull, Eduardo Carrascosa, Linda Giacomozzi, Evan J Bieske, Mark H Stockett
The intrinsic optical properties and photochemistry of flavin adenine dinucleotide (FAD) dianions are investigated using a combina..
Reversible Photoisomerization of the Isolated Green Fluorescent Protein Chromophore
Eduardo Carrascosa, James N Bull, Michael S Scholz, Neville JA Coughlan, Seth Olsen, Uta Wille, Evan J Bieske
Fluorescent proteins have revolutionized the visualization of biological processes, prompting efforts to understand and control th..
Linkage Photoisomerization of an Isolated Ruthenium Sulfoxide Complex: Sequential versus Concerted Rearrangement
Michael S Scholz, James N Bull, Eduardo Carrascosa, Brian D Adamson, Gilbert K Kosgei, Jeffrey J Rack, Evan J Bieske
Ruthenium sulfoxide complexes undergo thermally reversible linkage isomerization of sulfoxide ligands from S- to O-bound in respon..
Differential-Mobility Spectrometry of 1-Deoxysphingosine Isomers: New Insights into the Gas Phase Structures of Ionized Lipids
Berwyck LJ Poad, Alan T Maccarone, Haibo Yu, Todd W Mitchell, Essa M Saied, Christoph Arenz, Thorsten Hornemann, James N Bull, Evan J Bieske, Stephen J Blanksby
Separation and structural identification of lipids remain a major challenge for contemporary lipidomics. Regioisomeric lipids diff..
Photoswitching an Isolated Donor-Acceptor Stenhouse Adduct
James N Bull, Eduardo Carrascosa, Neil Mallo, Michael S Scholz, Gabriel da Silva, Jonathon E Beves, Evan J Bieske
Donor-acceptor Stenhouse adducts (DASAs) are a new class of photoswitching molecules with excellent fatigue resistance and synthet..
From E to Z and back again: reversible photoisomerisation of an isolated charge-tagged azobenzene
James N Bull, Michael S Scholz, Eduardo Carrascosa, Evan J Bieske
Substituted azobenzenes serve as chromophores and actuators in a wide range of molecular photoswitches. Here, tandem ion mobility ..
Photoisomerization of Protonated Azobenzenes in the Gas Phase
Michael S Scholz, James N Bull, Neville JA Coughlan, Eduardo Carrascosa, Brian D Adamson, Evan J Bieske
Because of their high photoisomerization efficiencies, azobenzenes and their functionalized derivatives are used in a broad range ..
A strong cis-effect in an imidazole/imidazolium substituted alkene
Dayne C Georgiou, Mohammad A Haghighatbin, Conor F Hogan, Michael S Scholz, James Bull, Evan J Bieske, David JD Wilson, Jason L Dutton
We report the first example of an alkene with two carbon‐bound substituents (imidazole and imidazolium rings) where the Z‐isomer h..
Online measurement of photoisomerisation efficiency in solution using ion mobility mass spectrometry
James N Bull, Eduardo Carrascosa, Michael S Scholz, Neville JA Coughlan, Evan J Bieske
The photoisomerisation of charged molecules in solution is probed directly using ion mobility mass spectrometry with electrospray ..
Isomerisation of an intramolecular hydrogen-bonded photoswitch: protonated azobis(2-imidazole)
James N Bull, Michael S Scholz, Neville JA Coughlan, Evan J Bieske
Photoisomerisation of protonated azobis(2-imidazole), an intramolecular hydrogen-bonded azoheteroarene photoswitch molecule, is in..
Electronic spectrum and photodissociation chemistry of the linear methyl propargyl cation H2C4H3
Katherine J Catani, Giel Muller, Gabriel da Silva, Evan J Bieske
The electronic spectrum of the methyl propargyl cation (2-butyn-1-yl cation, H2C4H3+) is measured over the 230-270 nm range by pho..
Monitoring Isomerization of Molecules in Solution Using Ion Mobility Mass Spectrometry
James N Bull, Michael S Scholz, Neville JA Coughlan, Akio Kawai, Evan J Bieske
An ion mobility spectrometer (IMS) with an electrospray ion source is used to investigate photo and thermal isomerization of photo..
Photo and Collision Induced Isomerization of a Cyclic Retinal Derivative: An Ion Mobility Study
Neville JA Coughlan, Michael S Scholz, Christopher S Hansen, Adam J Trevitt, Brian D Adamson, Evan J Bieske
A cationic degradation product, formed in solution from retinal Schiff base (RSB), is examined in the gas phase using ion mobility..