Structurally Nanoengineered Antimicrobial Polypeptide Particles (SNAPPs)

Grant number: DP160101312 | Funding period: 2016 - 2020

Completed

Abstract

This project aims to develop a new platform technology for the development of antimicrobial agents by combining expertise in polymer science and antimicrobial studies. It aims to develop new nanoengineered particles for combating antibiotic-resistant bacteria, investigate the influence of particle architecture on antibacterial properties, and determine the mechanism of action. This may support the development of antibiotic treatments using new polypeptide particles as antibacterial drugs, resulting in advances in nanobiotechnology, polymer therapeutics and advanced materials. The outcomes may revolutionise the synthetic approach to antimicrobial peptides and contribute significantly towards ..

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Related publications (12)

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Cationic Antimicrobial Peptides Are Leading the Way to Combat Oropathogenic Infections.

Bruce Lin, Rong Li, Thomas NG Handley, John D Wade, Wenyi Li, Neil M O'Brien-Simpson

2021-09-30

Oral dental infections are one of the most common diseases affecting humans, with caries and periodontal disease having the highes..

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Plasma Corona Protects Human Immune Cells from Structurally Nanoengineered Antimicrobial Peptide Polymers

Alessia CG Weiss, Steven J Shirbin, Hannah G Kelly, Quinn A Besford, Stephen J Kent, Greg G Qiao

2021-07-28

Safe and effective antimicrobials are needed to combat emerging antibiotic-resistant bacteria. Structurally nanoengineered antimic..

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Chemically modified and conjugated antimicrobial peptides against superbugs

Wenyi Li, Frances Separovic, Neil M O'Brien-Simpson, John D Wade

2021-04-21

Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050, will lead to more deaths from bacteri..

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Recent Applications of Aggregation Induced Emission Probes for Antimicrobial Peptide Studies

Tracey Luu, Wenyi Li, Neil M O'Brien-Simpson, Yuning Hong

2021-03-25

Antimicrobial peptides (AMPs) are being intensively investigated as they are considered promising alternatives to antibiotics wher..

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Human glucose-dependent insulinotropic polypeptide (GIP) is an antimicrobial adjuvant re-sensitising multidrug-resistant Gram-negative bacteria

Da'san MM Jaradat, Nehaya Al-Karablieh, Basmah HM Zaarer, Wenyi Li, Khalil KY Saleh, Anas J Rasras, Saeid Abu-Romman, Neil M O'Brien-Simpson, John D Wade

2021-03-01

Increasing antibiotic resistance in Gram-negative bacteria has mandated the development of both novel antibiotics and alternative ..

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Multifunctional Antimicrobial Polypeptide-Selenium Nanoparticles Combat Drug-Resistant Bacteria

Tao Huang, James A Holden, Eric C Reynolds, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

2020-12-16

Antibiotic-resistant bacteria are a severe threat to human health. The World Health Organization's Global Antimicrobial Surveillan..

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Peripheral memory T-cell profile is modified in patients undergoing periodontal management

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, James A Holden, Eric C Reynolds, Ivan B Darby, Neil M O'Brien-Simpson

2020-11-22

AIMS: T-cells are known to have a role in periodontitis, however, the effect of periodontal therapy on peripheral memory T-cells i..

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Peripheral T helper cell profiles during management of periodontitis

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Neil M O'Brien-Simpson, Eric C Reynolds, Ivan B Darby

2020-11-12

AIM: Periodontitis has been associated with other systemic diseases with underlying inflammation responsible for the shared link. ..

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Antimicrobial nanoparticle coatings for medical implants: Design challenges and prospects

Xin Li, Tao Huang, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

2020-11-01

Microbial colonization, infection, and biofilm formation are major complications in the use of implants and are the predominant ri..

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Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids.

Alicia Rasines Mazo, Stephanie Allison-Logan, Fatemeh Karimi, Nicholas Jun-An Chan, Wenlian Qiu, Wei Duan, Neil M O'Brien-Simpson, Greg G Qiao

2020-07-21

Polypeptides have attracted considerable attention in recent decades due to their inherent biodegradability and tunable cytocompat..

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Architectural Effects of Star-Shaped "Structurally Nanoengineered Antimicrobial Peptide Polymers" (SNAPPs) on Their Biological Activity

Steven J Shirbin, Ignacio Insua, James A Holden, Jason C Lenzo, Eric C Reynolds, Neil M O'Brien-Simpson, Greg G Qiao

2018-11-01

In this work, the effect of two key structural parameters, number of arms and arm length, of star-shaped "structurally nanoenginee..

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Antimicrobial polymeric nanoparticles

Shu J Lam, Edgar HH Wong, Cyrille Boyer, Greg G Qiao

2018-01-01

Currently, infections caused by multidrug-resistant bacteria have reached critical levels. Thus, various approaches are being expl..

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