Structurally Nanoengineered Antimicrobial Polypeptide Particles (SNAPPs)
Grant number: DP160101312 | Funding period: 2016 - 2020
This project aims to develop a new platform technology for the development of antimicrobial agents by combining expertise in polymer science and antimicrobial studies. It aims to develop new nanoengineered particles for combating antibiotic-resistant bacteria, investigate the influence of particle architecture on antibacterial properties, and determine the mechanism of action. This may support the development of antibiotic treatments using new polypeptide particles as antibacterial drugs, resulting in advances in nanobiotechnology, polymer therapeutics and advanced materials. The outcomes may revolutionise the synthetic approach to antimicrobial peptides and contribute significantly towards ..View full description
Related publications (12)
Cationic Antimicrobial Peptides Are Leading the Way to Combat Oropathogenic Infections.
Bruce Lin, Rong Li, Thomas NG Handley, John D Wade, Wenyi Li, Neil M O'Brien-Simpson
Oral dental infections are one of the most common diseases affecting humans, with caries and periodontal disease having the highes..
Plasma Corona Protects Human Immune Cells from Structurally Nanoengineered Antimicrobial Peptide Polymers
Alessia CG Weiss, Steven J Shirbin, Hannah G Kelly, Quinn A Besford, Stephen J Kent, Greg G Qiao
Safe and effective antimicrobials are needed to combat emerging antibiotic-resistant bacteria. Structurally nanoengineered antimic..
Human glucose-dependent insulinotropic polypeptide (GIP) is an antimicrobial adjuvant re-sensitising multidrug-resistant Gram-negative bacteria
Da'san MM Jaradat, Nehaya Al-Karablieh, Basmah HM Zaarer, Wenyi Li, Khalil KY Saleh, Anas J Rasras, Saeid Abu-Romman, Neil M O'Brien-Simpson, John D Wade
Increasing antibiotic resistance in Gram-negative bacteria has mandated the development of both novel antibiotics and alternative ..
Multifunctional Antimicrobial Polypeptide-Selenium Nanoparticles Combat Drug-Resistant Bacteria
Tao Huang, James A Holden, Eric C Reynolds, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor
Antibiotic-resistant bacteria are a severe threat to human health. The World Health Organization's Global Antimicrobial Surveillan..
Peripheral memory T-cell profile is modified in patients undergoing periodontal management
Nidhi Medara, Jason C Lenzo, Katrina A Walsh, James A Holden, Eric C Reynolds, Ivan B Darby, Neil M O'Brien-Simpson
AIMS: T-cells are known to have a role in periodontitis, however, the effect of periodontal therapy on peripheral memory T-cells i..
Peripheral T helper cell profiles during management of periodontitis
Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Neil M O'Brien-Simpson, Eric C Reynolds, Ivan B Darby
AIM: Periodontitis has been associated with other systemic diseases with underlying inflammation responsible for the shared link. ..
Antimicrobial nanoparticle coatings for medical implants: Design challenges and prospects
Xin Li, Tao Huang, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor
Microbial colonization, infection, and biofilm formation are major complications in the use of implants and are the predominant ri..
Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids.
Alicia Rasines Mazo, Stephanie Allison-Logan, Fatemeh Karimi, Nicholas Jun-An Chan, Wenlian Qiu, Wei Duan, Neil M O'Brien-Simpson, Greg G Qiao
Polypeptides have attracted considerable attention in recent decades due to their inherent biodegradability and tunable cytocompat..
Architectural Effects of Star-Shaped "Structurally Nanoengineered Antimicrobial Peptide Polymers" (SNAPPs) on Their Biological Activity
Steven J Shirbin, Ignacio Insua, James A Holden, Jason C Lenzo, Eric C Reynolds, Neil M O'Brien-Simpson, Greg G Qiao
In this work, the effect of two key structural parameters, number of arms and arm length, of star-shaped "structurally nanoenginee..