The function of the ribbon structure of the Golgi apparatus in vertebrates
Grant number: DP160102394 | Funding period: 2016 - 2019
The aim of the project is to determine the function of the Golgi ribbon structure in higher order cell functions, including metabolism, cell cycle, and cell polarity in both cultured cells and whole organisms. Understanding of the functions of the Golgi has been restricted to the regulation of glycosylation and membrane transport. However, it is now recognised that the Golgi apparatus feeds into the wiring of a range of cellular networks in higher organisms such as cell polarisation, directed migration, metabolism and autophagy. Vertebrates have evolved mechanisms for joining individual Golgi stacks into a ribbon structure. The relevance of this ribbon structure remains a mystery. The projec..View full description
Related publications (7)
Interacting partners of Golgi-localized small G protein Arl5b identified by a combination of in vivo proximity labelling and GFP-Trap pull down
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The small G protein Arl5b is localised on the trans-Golgi network (TGN) and regulates endosomes-to-TGN transport. Here, we combine..
The Golgi ribbon in mammalian cells negatively regulates autophagy by modulating mTOR activity
Prajakta Gosavi, Fiona J Houghton, Paul J McMillan, Eric Hanssen, Paul A Gleeson
In vertebrates, individual Golgi stacks are joined into a compact ribbon structure; however, the relevance of a ribbon structure h..