Understanding mechanisms of sex programming of cardiovascular development
Grant number: DP160102404 | Funding period: 2016 - 2019
The goal of this project is to track the influence of sex and sex hormones through crucial lifespan timepoints to define how specific patterns of gene signalling determine adult cardiovascular traits at cell, tissue and systems level. Sexually distinct cardiovascular traits are conserved across mammalian species. Early developmental events are known to be important in influencing later adult characteristics, but how adult cardiovascular functions are ‘programmed’ differently for males and females is not understood. The project aims to uncover the importance of the placenta in regulating foetus exposure to sex steroids and the crucial effects of the pubertal hormone surge in shaping cardiovas..View full description
Related publications (4)
Cardiomyocyte functional screening: interrogating comparative electrophysiology of high-throughput model cell systems
Simon P Wells, Helen M Waddell, Choon Boon Sim, Shiang Y Lim, Gabriel B Bernasochi, Davor Pavlovic, Paulus Kirchhof, Enzo R Porrello, Lea MD Delbridge, James R Bell
Cardiac arrhythmias of both atrial and ventricular origin are an important feature of cardiovascular disease. Novel antiarrhythmic..
Myocardial Energy Stress, Autophagy Induction, and Cardiomyocyte Functional Responses
Lorna J Daniels, Upasna Varma, Marco Annandale, Eleia Chan, Kimberley M Mellor, Lea MD Delbridge
Significance: Energy stress in the myocardium occurs in a variety of acute and chronic pathophysiological contexts, including isch..
Impact of Estrogens on the Regulation of White, Beige, and Brown Adipose Tissue Depots
Gabriel B Bernasochi, James R Bell, Evan R Simpson, Lea MD Delbridge, Wah Chin Boon
As adipose tissue depots are active endocrine organs, they secrete a variety of hormones (including estrogens from white adipose) ..
Pericardial adipose and aromatase: A new translational target for aging, obesity and arrhythmogenesis?
Gabriel B Bernasochi, Wah Chin Boon, Claire L Curl, Upasna Varma, Salvatore Pepe, Marianne Tare, Laura J Parry, Evdokia Dimitriadis, Stephen B Harrap, Chrishan J Nalliah, Jonathan M Kalman, Lea MD Delbridge, James R Bell
A correlation exists between the extent of pericardial adipose and atrial fibrillation (AF) risk, though the underlying mechanisms..