Regulation of Ribosomal Rna Gene Chromatin During Malignant Transformation

Grant number: 1100654 | Funding period: 2016 - 2019

Completed

Abstract

The overarching goal of this proposal is to determine the molecular basis for tumour cell dependence on activated ribosomal RNA gene repeats (rDNA). Our working model posits that rDNA repeats become activated through changes in rDNA chromatin structure that include increased binding of the RNA Polymerase I transcription factor UBF.

Related publications (3)

Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway

KM Hannan, P Soo, MS Wong, JK Lee, N Hein, P Poh, KD Wysoke, TD Williams, C Montellese, LK Smith, SJ Al-Obaidi, L Núñez-Villacís, M Pavy, JS He, KM Parsons, KE Loring, T Morrison, J Diesch, G Burgio, R Ferreira

2022-11-01

The nucleolar surveillance pathway monitors nucleolar integrity and responds to nucleolar stress by mediating binding of ribosomal..

rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461

J Son, KM Hannan, G Poortinga, N Hein, DP Cameron, ARD Ganley, KE Sheppard, RB Pearson, RD Hannan, E Sanij

2020-07-03

Hyperactivation of RNA polymerase I (Pol I) transcription of ribosomal RNA (rRNA) genes (rDNA) is a key determinant of growth and ..

Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis

LE Kerry, EE Pegg, DP Cameron, J Budzak, G Poortinga, KM Hannan, RD Hannan, G Rudenko

2017-03-06

Trypanosoma brucei relies on an essential Variant Surface Glycoprotein (VSG) coat for survival in the mammalian bloodstream. High ..

University of Melbourne Researchers

Elaine Sanij