ESTABLISHING THE MAXIMUM SAFE STIMULATION PARAMETERS FOR PLATINUM COCHLEAR IMPLANT ELECTRODE ARRAYS.(GRANT11829653 )

Platinum dissolution and tissue response following long-term electrical stimulation at high charge densities

Robert K Shepherd, Paul M Carter, Ashley N Dalrymple, Ya Lang Enke, Andrew K Wise, Trung Nguyen, James Firth, Alex Thompson, James B Fallon

2021-04-01

OBJECTIVE: Established guidelines for safe levels of electrical stimulation for neural prostheses are based on a limited range of ..

Chronic intracochlear electrical stimulation at high charge densities: reducing platinum dissolution

Robert K Shepherd, Paul M Carter, Ya Lang Enke, Alex Thompson, Brianna Flynn, Ella P Trang, Ashley N Dalrymple, James B Fallon

2020-10-01

OBJECTIVE: Cochleae of long-term cochlear implant users have shown evidence of particulate platinum (Pt) corroded from the surface..

New molecular therapies for the treatment of hearing loss

Yutian Ma, Andrew K Wise, Robert K Shepherd, Rachael T Richardson

2019-08-01

An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing loss is characterized by degeneration of..

Chronic intracochlear electrical stimulation at high charge densities results in platinum dissolution but not neural loss or functional changes in vivo

Robert K Shepherd, Paul M Carter, Ya Lang Enke, Andrew K Wise, James B Fallon

2019-04-01

OBJECTIVE: Although there are useful guidelines defining the boundary between damaging and non-damaging electrical stimulation the..

The development of neural stimulators: a review of preclinical safety and efficacy studies

Robert K Shepherd, Joel Villalobos, Owen Burns, David AX Nayagam

2018-08-01

OBJECTIVE: Given the rapid expansion of the field of neural stimulation and the rigorous regulatory approval requirements required..

Structural and Ultrastructural Changes to Type I Spiral Ganglion Neurons and Schwann Cells in the Deafened Guinea Pig Cochlea

Andrew K Wise, Remy Pujol, Thomas G Landry, James B Fallon, Robert K Shepherd

2017-12-01

Sensorineural hearing loss is commonly caused by damage to cochlear sensory hair cells. Coinciding with hair cell degeneration, th..

Evaluation of focused multipolar stimulation for cochlear implants: a preclinical safety study

Robert K Shepherd, Andrew K Wise, Ya Lang Enke, Paul M Carter, James B Fallon

2017-08-01

OBJECTIVE: Cochlear implants (CIs) have a limited number of independent stimulation channels due to the highly conductive nature o..