FZD7 AS A THERAPEUTIC TARGET FOR GASTRIC CANCER
Grant number: 1099302 | Funding period: 2016 - 2018
Fzd receptors are often upregulated in gastric cancer, and recent studies have shown that targeting these receptors has be effective at reducing cancer cell growth in other cancers including prostate and breast. This project will use cutting edge technology to firstly determine the specific requirement for Fzd receptors during gastric cancer and then determine the therapeutic benefit of using an antibody to target these receptors in mouse models and human gastric cancer cells.
Related publications (12)
Captopril, a Renin-Angiotensin System Inhibitor, Attenuates Features of Tumor Invasion and Down-Regulates C-Myc Expression in a Mouse Model of Colorectal Cancer Liver Metastasis
Georgina E Riddiough, Theodora Fifis, Katrina A Walsh, Vijayaragavan Muralidharan, Christopher Christophi, Bang M Tran, Elizabeth Vincan, Marcos V Perini
(1) Background: Recent clinical and experimental data suggests that the liver's regenerative response following partial hepatectom..
The Hepatitis B Virus Pre-Core Protein p22 Activates Wnt Signaling
Manh Tran Bang, Dustin James Flanagan, Gregor Ebert, Nadia Warner, Tran Hoanh, Theodora Fifis, Georgios Kastrappis, Christopher Christophi, Marc Pellegrini, Joseph Torresi, Toby James Phesse, Elizabeth Vincan
An emerging theme for Wnt-addicted cancers is that the pathway is regulated at multiple steps via various mechanisms. Infection wi..
The Function of Lgr5( ) Cells in the Gastric Antrum Does Not Require Fzd7 or Myc In Vivo
Dustin Flanagan, Nick Barker, Matthias Ernst, Elizabeth Vincan, Toby Phesse
The extreme chemical and mechanical forces endured by the gastrointestinal tract drive a constant renewal of the epithelial lining..
HBV-related hepatocarcinogenesis: the role of signalling pathways and innovative ex vivo research models
Joseph Torresi, Manh Tran Bang, Dale Christiansen, Linda Earnest-Silveira, Renate Hilda Marianne Schwab, Elizabeth Vincan
BACKGROUND: Hepatitis B virus (HBV) is the leading cause of liver cancer, but the mechanisms by which HBV causes liver cancer are ..
Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations
Dustin J Flanagan, Nick Barker, Natasha S Di Costanzo, Elizabeth A Mason, Austin Gurney, Valerie S Meniel, Sarah Koushyar, Chloe R Austin, Matthias Ernst, Helen B Pearson, Alex Boussioutas, Hans Clevers, Toby J Phesse, Elizabeth Vincan
A subset of patients with gastric cancer have mutations in genes that participate in or regulate Wnt signaling at the level of lig..
Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells
Renate HM Schwab, Nancy Amin, Dustin J Flanagan, Timothy M Johanson, Toby J Phesse, Elizabeth Vincan
BACKGROUND: Metastasis underlies most colorectal cancer mortality. Cancer cells spread through the body as single cells or small c..
Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo
Dustin J Flanagan, Nick Barker, Cameron Nowell, Hans Clevers, Matthias Ernst, Toby J Phesse, Elizabeth Vincan
The gastric epithelium consists of tubular glandular units, each containing several differentiated cell types, and populations of ..