DYNAMIC NUCLEAR POLARISATION SYSTEM FOR MOLECULAR STRUCTURE DETERMINATION
Grant number: LE160100120 | Funding period: 2016 - 2016
This project aims to establish the first dynamic nuclear polarisation (DNP) spectrometer in Australia. DNP is designed to enhance the sensitivity of nuclear magnetic resonance techniques for molecular structure determination. The instrumentation would enable advancements in the biological and material sciences by providing enhanced sensitivity to allow biomolecular and in-cell structure determination and the characterisation of new advanced materials. The facility is expected to drive interdisciplinary research and bring together scientific expertise that will accelerate advances in biomedical science, biochemistry, forensic science and security, polymers and nano-electronics.
Related publications (10)
TOAC spin-labeled peptides tailored for DNP-NMR studies in lipid membrane environments.
Shiying Zhu, Ehsan Kachooei, Jeffrey R Harmer, Louise J Brown, Frances Separovic, Marc-Antoine Sani
The benefit of combining in-cell solid-state dynamic nuclear polarization (DNP) NMR and cryogenic temperatures is providing suffic..
C-terminus amidation influences biological activity and membrane interaction of maculatin 1.1
Shiying Zhu, Wenyi Li, Neil O'Brien-Simpson, Frances Separovic, Marc-Antoine Sani
Cationic antimicrobial peptides have been investigated for their potential use in combating infections by targeting the cell membr..
NMR Chemical Shift and Methylation of 4-Nitroimidazole: Experiment and Theory
Frederick Backler, Marc Antoine Sani, Frances Separovic, Vladislav Vasilyev, Feng Wang
Nitroimidazoles and derivatives are a class of active pharmaceutical ingredients (APIs) first introduced sixty years ago. As anti-..
DNP NMR spectroscopy reveals new structures, residues and interactions in wild spider silks
Hamish C Craig, Sean J Blamires, Marc-Antoine Sani, Michael M Kasumovic, Aditya Rawal, James M Hook
DNP solid state NMR spectroscopy allows non-targeted analysis of wild spider silk in unprecedented detail at natural abundance, re..
Elucidating the bactericidal mechanism of action of the linear antimicrobial tetrapeptide BRBR-NH2
Qiu Ying Lau, Jianguo Li, Marc-Antoine Sani, Sheetal Sinha, Yan Li, Fui Mee Ng, CongBao Kang, Surajit Bhattacharjya, Frances Separovic, Chandra Verma, Cheng San Brian Chia
Linear antimicrobial peptides, with their rapid bactericidal mode of action, are well-suited for development as topical antibacter..
Probing Ionic Liquid Electrolyte Structure via the Glassy State by Dynamic Nuclear Polarization NMR Spectroscopy
Marc-Antoine Sani, Pierre-Alexandre Martin, Ruhamah Yunis, Fangfang Chen, Maria Forsyth, Michael Deschamps, Luke A O'Dell
Dynamic nuclear polarization (DNP)-enhanced solid-state NMR spectroscopy has been used to study an ionic liquid salt solution (N-m..