Assessing the mechanisms and dynamics of myelination in the brain
Grant number: FT150100207 | Funding period: 2016 - 2016
This project is expected to refine our understanding of brain plasticity by revealing how myelin plasticity optimises brain function in response to experience. Using a multidisciplinary approach incorporating animal studies, mathematical modelling and computational neuroscience, the project seeks to redefine our understanding of myelin remodelling using an entirely new integrated cell-to-system approach. The expected outcome is fundamental knowledge revealing how myelination is dynamically regulated by neural activity throughout life. This may transform current understanding of neuroplasticity that could aid in the future development of strategies to improve brain health.
Related publications (3)
Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner
Stanislaw Mitew, Ilan Gobius, Laura R Fenlon, Stuart J McDougall, David Hawkes, Yao Lulu Xing, Helena Bujalka, Andrew L Gundlach, Linda J Richards, Trevor J Kilpatrick, Tobias D Merson, Ben Emery
Mounting evidence suggests that neuronal activity influences myelination, potentially allowing for experience-driven modulation of..
Evidence for Cooperative Selection of Axons for Myelination by Adjacent Oligodendrocytes in the Optic Nerve
Darragh M Walsh, Tobias D Merson, Kerry A Landman, Barry D Hughes
The cellular mechanisms that regulate the topographic arrangement of myelin internodes along axons remain largely uncharacterized...