Unravelling The Binding And Activation Mechanism Of A Complex G Protein-Coupled Receptor

Grant number: 1100676 | Funding period: 2016 - 2019

Completed

Abstract

The peptide hormone relaxin is currently in a Phase III trial for the treatment of heart failure. However the peptide is not a good drug as it can't be taken orally and is very expensive to produce. We will study the interaction of relaxin with its cell surface receptor and the mechanisms by which the receptor functions. The knowledge gained will aid in the design of smaller, more potent and orally active forms of relaxin for the treatment of heart failure