AN ULTRA HIGH RESOLUTION MASS SPECTROMETRY FACILITY FOR LIPIDOMICS RESEARCH
Grant number: LE160100015 | Funding period: 2016 - 2017
This proposal aims to establish an ultra-high-resolution, accurate mass spectrometry facility in Australia for comprehensive lipidomics research. The platform would consist of a Thermo Scientific Orbitrap Fusion mass spectrometer interfaced with ultra-high-pressure high-performance liquid chromatography. This proposal will address a major need for advanced mass spectrometry-based lipid analysis capabilities across mammalian, plant, parasite, and microalgae research disciplines, as well as enabling fundamental studies of lipid separation, chemistry and reactivity. The instrumentation would be applicable to a diverse range of projects including studies of the role of lipid metabolism in mammal..View full description
Related publications (3)
Developmental lipidome and proteome of Haemonchus contortus reflect unique adaptations in the transition to parasitism
S Nie, Tao Wang, Guangxu Ma, Ching-Seng Ang, Pasi Korhonen, Rong Xu, Anson Koehler, Richard SIMPSON, David GREENING, Gavin Reid, Nicholas Williamson, Robin Gasser
There has been a dearth of lipidomic and proteomic data sets to underpin fundamental investigations of parasites and parasitism at..
Molecular alterations during larval development of Haemonchus contortus in vitro are under tight post-transcriptional control
Guangxu Ma, Tao Wang, Pasi K Korhonen, Ching-Seng Ang, Nicholas A Williamson, Neil D Young, Andreas J Stroehlein, Ross S Hall, Anson V Koehler, Andreas Hofmann, Robin B Gasser
In this study, we explored the molecular alterations in the developmental switch from the L3 to the exsheathed L3 (xL3) and to the..
Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development
Molly Parkyn Schneider, Boyin Liu, Philipp Glock, Annika Suttie, Emma McHugh, Dean Andrew, Steven Batinovic, Nicholas Williamson, Eric Hanssen, Paul McMillan, Marion Hliscs, Leann Tilley, Matthew WA Dixon
Transmission of malaria parasites relies on the formation of a specialized blood form called the gametocyte. Gametocytes of the hu..