UNDERSTANDING MALARIA IN THE HUMAN HOST

Grant number: 1092789 | Funding period: 2016 - 2021

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Abstract

Malaria is one of the worlds most significant health problems and is caused by protozoan parasites of the genus Plasmodium. We aim to understand the biology, pathogenesis, and epidemiology of P. falciparum and P. vivax infections together with a strong translational direction. Our studies will thus lead to the discovery and development of novel tools aiding in the renewed efforts for the global elimination of malaria.

Related publications (6)

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Innate immune responses to malaria-infected erythrocytes in pregnant women: Effects of gravidity, malaria infection, and geographic location

Marzieh Jabbarzare, Madi Njie, Anthony Jaworowski, Alexandra J Umbers, Maria Ome-Kaius, Wina Hasang, Louise M Randall, Bill Kalionis, Stephen J Rogerson

2020-07-29

BACKGROUND: Malaria in pregnancy causes maternal, fetal and neonatal morbidity and mortality, and maternal innate immune responses..

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Antibody effector functions in malaria and other parasitic diseases: a few needles and many haystacks

Elizabeth H Aitken, Siddhartha Mahanty, Stephen J Rogerson

2020-02-24

Many parasitic infections stimulate antibody responses in their mammalian hosts. The ability of these antibodies to protect agains..

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Evaluating antibody functional activity and strain-specificity of vaccine candidates for malaria in pregnancy using in vitro phagocytosis assays

Mirja Hommel, Jo-Anne Chan, Alexandra J Umbers, Christine Langer, Stephen J Rogerson, Joseph D Smith, James G Beeson

2018-01-29

BACKGROUND: Malaria in pregnancy is a major cause of poor maternal and infant health, and is associated with the sequestration of ..

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A sandwich enzyme-linked immunosorbent assay for the quantitation of human plasma ferritin

Andie Bleicher, Holger W Unger, Stephen J Rogerson, Elizabeth H Aitken

2018-01-01

There is a lack of published enzyme linked immunosorbent assay (ELISA) protocols which use commercially available reagents for the..

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Malaria, malnutrition, and birthweight: A meta-analysis using individual participant data

Jordan E Cates, Holger W Unger, Valerie Briand, Nadine Fievet, Innocent Valea, Halidou Tinto, Umberto D'Alessandro, Sarah H Landis, Seth Adu-Afarwuah, Kathryn G Dewey, Feiko O Ter Kuile, Meghna Desai, Stephanie Dellicour, Peter Ouma, Julie Gutman, Martina Oneko, Laurence Slutsker, Dianne J Terlouw, Simon Kariuki, John Ayisi

2017-08-01

BACKGROUND: Four studies previously indicated that the effect of malaria infection during pregnancy on the risk of low birthweight..

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Functional Antibodies and Protection against Blood-Stage Malaria

Andrew Teo, Gaoqian Feng, Graham V Brown, James G Beeson, Stephen J Rogerson

2016-11-01

Numerous efforts to understand the functional roles of antibodies demonstrated that they can protect against malaria. However, it ..

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