CELL-FREE DNA IN KIDNEY TRANSPLANT REJECTION
Grant number: 1114931 | Funding period: 2016 - 2017
20% of transplanted kidneys undergo rejection. This can permanently damage or destroy the transplant. Presently, rejection is identified when the kidney function deteriorates. This can occur late after rejection has started. To confirm the diagnosis of rejection, an invasive biopsy associated with discomfort and risks is required. This study will evaluate the use of a simpler blood test to monitor for rejection, allowing earlier and safer identification and treatment.
Related publications (1)
Diagnostic application of kidney allograft-derived absolute cell-free DNA levels during transplant dysfunction
John B Whitlam, Ling Ling, Alison Skene, John Kanellis, Francseco L Ierino, Howard R Slater, Damien L Bruno, David A Power
Graft-derived cell-free DNA (donor-derived cell-free DNA) is an emerging marker of kidney allograft injury. Studies examining the ..