BIOLOGICAL ACTIONS OF ESTRADIOL IN MEN
Grant number: 1099173 | Funding period: 2016 - 2022
In men, oestrogen may be important for strong bones and maintaining a healthy weight. Men with prostate cancer are given medical castration treatment to decrease testosterone, because testosterone is required for prostate cancer growth. Because oestrogen is derived from testosterone, they also have very low oestrogen levels. We want to conduct a trial in these men to find out whether giving back oestrogen will prevent bone loss and weight gain, among other health benefits.
Related publications (1)
Effect of estradiol on cognition in men undergoing androgen deprivation therapy: A randomized placebo-controlled trial
Nicholas Russell, James Allebone, Orwa Dandash, Rudolf Hoermann, Ada S Cheung, Jeffrey D Zajac, David J Handelsman, Richard A Kanaan, Mathis Grossmann
OBJECTIVE: Roles for estradiol in modulating cognition in men remain uncertain. We assessed the isolated effects of estradiol on c..