Taking Aim at a New Target for More Effective Malignant Brain Cancer Treatment

PI3K Activation in Neural Stem Cells Drives Tumorigenesis which can be Ameliorated by Targeting the cAMP Response Element Binding (CREB) Protein

Paul M Daniel, Gulay Filiz, Daniel V Brown, Michael Christie, Paul M Waring, Yi Zhang, John M Haynes, Colin Pouton, Dustin Flanagan, Elizabeth Vincan, Terrance G Johns, Karen Montgomery, Wayne A Phillips, Theo Mantamadiotis

2018-10-01

BACKGROUND: Hyperactivation of phosphoinositide 3-kinase (PI3K) signaling is common in cancers, but the precise role of the pathwa..

Investigating Neural Stem Cell and Glioma Stem Cell Self-renewal Potential Using Extreme Limiting Dilution Analysis (ELDA)

Hong PT Nguyen, Paul M Daniel, Gulay Filiz, Theo Mantamadiotis

2018-09-05

Glioma stem cells (GSC) grown as neurospheres exhibit similar characteristics to neural stem cells (NSC) grown as neurospheres, in..

Intratumor MAPK and PI3K signaling pathway heterogeneity in glioblastoma tissue correlates with CREB signaling and distinct target gene signatures

PM Daniel, G Filiz, MJ Tymms, RG Ramsay, AH Kaye, SS Stylli, T Mantamadiotis

2018-01-01

Limitations in discovering useful tumor biomarkers and drug targets is not only due to patient-to-patient differences but also due..

Towards targeting PI3K-dependent regulation of gene expression in brain cancer

T Mantamadiotis

2017-06-01

The PI3K pathway is one of the most highly perturbed cell signaling pathways in human cancer, including the most common malignant ..

Expression of CD133 and CD44 in glioblastoma stem cells correlates with cell proliferation, phenotype stability and intratumor heterogeneity

DV Brown, G Filiz, PM Daniel, F Hollande, S Dworkin, S Amiridis, N Kountouri, W Ng, AP Morokoff, T Mantamadiotis

2017-02-01

Glioblastoma (GBM) is a heterogeneous tumor of the brain with a poor prognosis due to recurrence and drug resistance following the..

Sensitivity of GBM cells to cAMP agonist-mediated apoptosis correlates with CD44 expression and agonist resistance with MAPK signaling

PM Daniel, G Filiz, T Mantamadiotis

2016-12-01

In some cell types, activation of the second messenger cAMP leads to increased expression of proapoptotic Bim and subsequent cell ..