MINCLE HAS A DUAL ROLE IN TISSUE LOSS AND INFLAMMATION AFTER ISCHEMIC INJURY

Grant number: 1057846 | Funding period: 2016 - 2018

Completed

Abstract

This project investigates two of the life-changing cardiovascular events that most commonly impact on Australians today; Heart attack and Stroke. These diseases often leave individuals debilitated with a long recovery period, and for many people the event is fatal. We have shown that blocking the action of an immune component, 'Mincle', reduces the inflammation associated with stroke, and improves recovery. This project looks at what Mincle does in brain and heart muscle, and why blocking Mincle protects cells from loss of oxygen.

Related publications (4)

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Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection

Takashi Imai, Takayuki Matsumura, Sabine Mayer-Lambertz, Christine A Wells, Eri Ishikawa, Suzanne K Butcher, Timothy C Barnett, Mark J Walker, Akihiro Imamura, Hideharu Ishida, Tadayoshi Ikebe, Tomofumi Miyamoto, Manabu Ato, Shouichi Ohga, Bernd Lepenies, Nina M van Sorge, Sho Yamasaki

2018-11-06

Group A Streptococcus (GAS) is a Gram-positive bacterial pathogen that causes a range of diseases, including fatal invasive infect..

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Dynamic interplay of innate and adaptive immunity during sterile retinal inflammation: Insights from the transcriptome

Riccardo Natoli, Elizabeth Mason, Haihan Jiao, Aaron Chuah, Hardip Patel, Nilisha Fernando, Krisztina Valter, Christine Wells, Jan Provis, Matt Rutar

2018-02-24

The pathogenesis of many retinal degenerations, such as age-related macular degeneration (AMD), is punctuated by an ill-defined ne..

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An atypical role for the myeloid receptor Mincle in central nervous system injury

Thiruma V Arumugam, Silvia Manzanero, Milena Furtado, Patrick J Biggins, Yu-Hsuan Hsieh, Mathias Gelderblom, Kelli PA MacDonald, Ekaterina Salimova, Yu-I Li, Othmar Korn, Deborah Dewar, I Mhairi Macrae, Robert B Ashman, Sung-Chun Tang, Nadia A Rosenthal, Marc J Ruitenberg, Tim Magnus, Christine A Wells

2017-06-01

The C-type lectin Mincle is implicated in innate immune responses to sterile inflammation, but its contribution to associated path..

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The Ground State of Innate Immune Responsiveness Is Determined at the Interface of Genetic, Epigenetic, and Environmental Influences

Edward Huang, Christine Anne Wells

2014-07-01

Monocytes and macrophages form the major cellular component of the innate immune system, with roles in tissue development, homeost..

University of Melbourne Researchers