MINCLE HAS A DUAL ROLE IN TISSUE LOSS AND INFLAMMATION AFTER ISCHEMIC INJURY

Grant number: 1057846 | Funding period: 2016 - 2018

Completed

Abstract

This project investigates two of the life-changing cardiovascular events that most commonly impact on Australians today; Heart attack and Stroke. These diseases often leave individuals debilitated with a long recovery period, and for many people the event is fatal. We have shown that blocking the action of an immune component, "Mincle", reduces the inflammation associated with stroke, and improves recovery. This project looks at what Mincle does in brain and heart muscle, and why blocking Mincle protects cells from loss of oxygen.

University of Melbourne Researchers