HIGH THROUGHPUT, INEXPENSIVE METHODS FOR TYPING IMMUNE SYSTEM GENES AND ASSESSING THEIR ROLE IN HUMAN DISEASE WORLDWIDE

Grant number: 1053756 | Funding period: 2016 - 2016

Completed

Abstract

Immune system genes are strongly implicated in many infectious and autoimmune diseases, as well as cancer. Some of these genes have many possible types due to natural selection in response to pathogens. This variability makes typing these genes very expensive. Developing accurate and inexpensive methods to type these genes is vital in understanding the role they play in susceptibility and progression of disease and will be important for the development of better diagnostic tests and treatments.

Related publications (8)

Scholarly works icon

Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis

Aimee L Hanson, Damjan Vukcevic, Stephen Leslie, Jessica Harris, Kim-Anh Le Cao, Tony J Kenna, Matthew A Brown

2020-08-01

The killer immunoglobulin-like receptors (KIRs), found predominantly on the surface of natural killer (NK) cells and some T-cells,..

Scholarly works icon

Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

Paul A Lyons, James E Peters, Federico Alberici, James Liley, Richard MR Coulson, William Astle, Chiara Baldini, Francesco Bonatti, Maria C Cid, Heather Elding, Giacomo Emmi, Joerg Epplen, Loic Guillevin, David RW Jayne, Tao Jiang, Iva Gunnarsson, Peter Lamprecht, Stephen Leslie, Mark A Little, Davide Martorana

2019-11-12

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-ne..

Scholarly works icon

The UK Biobank resource with deep phenotyping and genomic data

Clare Bycroft, Colin Freeman, Desislava Petkova, Gavin Band, Lloyd T Elliott, Kevin Sharp, Allan Motyer, Damjan Vukcevic, Olivier Delaneau, Jared O'Connell, Adrian Cortes, Samantha Welsh, Alan Young, Mark Effingham, Gil McVean, Stephen Leslie, Naomi Allen, Peter Donnelly, Jonathan Marchini

2018-10-11

Scholarly works icon

Significant variation between SNP-based HLA imputations in diverse populations: the last mile is the hardest.

DJ Pappas, A Lizee, V Paunic, KR Beutner, A Motyer, D Vukcevic, S Leslie, J Biesiada, J Meller, KD Taylor, X Zheng, LP Zhao, P-A Gourraud, JA Hollenbach, SJ Mack, M Maiers

2018-05-22

Four single nucleotide polymorphism (SNP)-based human leukocyte antigen (HLA) imputation methods (e-HLA, HIBAG, HLA*IMP:02 and MAG..

Scholarly works icon

Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank

Adrian Cortes, Calliope A Dendrou, Allan Motyer, Luke Jostins, Damjan Vukcevic, Alexander Dilthey, Peter Donnelly, Stephen Leslie, Lars Fugger, Gil McVean

2017-09-01

Scholarly works icon

Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA-DRB1

DJ Martino, S Ashley, J Koplin, J Ellis, R Saffery, SC Dharmage, L Gurrin, MC Matheson, B Kalb, I Marenholz, K Beyer, Y-A Lee, X Hong, X Wang, D Vukcevic, A Motyer, S Leslie, KJ Allen, MAR Ferreira

2017-02-01

Scholarly works icon

Imputation of KIR Types from SNP Variation Data

Damjan Vukcevic, James A Traherne, Sigrid Naess, Eva Ellinghaus, Yoichiro Kamatani, Alexander Dilthey, Mark Lathrop, Tom H Karlsen, Andre Franke, Miriam Moffatt, William Cookson, John Trowsdale, Gil McVean, Stephen Sawcer, Stephen Leslie

2015-10-01

Scholarly works icon

The fine-scale genetic structure of the British population

Stephen Leslie, Bruce Winney, Garrett Hellenthal, Dan Davison, Abdelhamid Boumertit, Tammy Day, Katarzyna Hutnik, Ellen C Royrvik, Barry Cunliffe, Daniel J Lawson, Daniel Falush, Colin Freeman, Matti Pirinen, Simon Myers, Mark Robinson, Peter Donnelly, Walter Bodmer

2015-03-19

Researchers