CLINICAL TRANSLATION OF A NEWLY DISCOVERED TRANSCRIPTIONAL FUSION INVOLVING THE MULTIDRUG RESISTANCE TRANSPORTER (ABCB1) IN RECURRENT DRUG RESISTANT OVARIAN CANCER

Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer

Elizabeth L Christie, Swetansu Pattnaik, Jessica Beach, Anthony Copeland, Nineveh Rashoo, Sian Fereday, Joy Hendley, Kathryn Alsop, Samuel L Brady, Greg Lamb, Ahwan Pandey, Anna deFazio, Heather Thorne, Andrea Bild, David DL Bowtell

2019-03-20

ABCB1 encodes Multidrug Resistance protein (MDR1), an ATP-binding cassette member involved in the cellular efflux of chemotherapeu..

Acquired chemotherapy resistance in ovarian cancer

EL Christie, DDL Bowtell

2017-11-01

Most women diagnosed with high-grade serous ovarian cancer (HGSC) develop recurrent disease and chemotherapy resistance, despite i..