TARGETING MUTANT P53 IN OESOPHAGEAL CANCER

Inhibiting system x(C)(-) and glutathione biosynthesis - a potential Achilles' heel in mutant-p53 cancers

Nicholas J Clemons, David S Liu, Cuong P Duong, Wayne A Phillips

2017-01-01

Effective therapeutic strategies to target mutant tumor protein p53 (TP53, best known as p53) cancers remain an unmet medical need..

Preclinical Models of Esophageal Adenocarcinoma for Drug Development

David S Liu, Cuong P Duong, Wayne A Phillips, Nicholas J Clemons

2016-12-01

The advent of multi-omic profiling of tumors, together with the increasing affordability of high-throughput drug screening program..