ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE

Grant number: 1113293 | Funding period: 2017 - 2021

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Abstract

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune or inflammatory diseases.

Related publications (13)

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A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response

R Lameris, A Shahine, DG Pellicci, AP Uldrich, S Gras, J Le Nours, RWJ Groen, J Vree, SJJ Reddiex, SM Quiñones-Parra, SK Richardson, AR Howell, S Zweegman, DI Godfrey, TD de Gruijl, J Rossjohn, HJ van der Vliet

2020-11-01

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Atypical TRAV1-2(-) T cell receptor recognition of the antigen-presenting molecule MR1

Wael Awad, Erin W Meermeier, Maria L Sandoval-Romero, Jerome Le Nours, Aneta H Worley, Megan D Null, Ligong Liu, James McCluskey, David P Fairlie, David M Lewinsohn, Jamie Rossjohn

2020-10-16

MR1 presents vitamin B-related metabolites to mucosal associated invariant T (MAIT) cells, which are characterized, in part, by th..

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Immune recognition of phosphoantigen-butyrophilin molecular complexes by gamma delta T cells

Adam P Uldrich, Marc Rigau, Dale I Godfrey

2020-10-05

Gamma-delta (γδ) T cells are an important component of the immune system. They are often enriched in non-lymphoid tissues and exhi..

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A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver T-RM Cell-Mediated Immunity against Malaria in Mice

Ana Maria Valencia-Hernandez, Wei Yi Ng, Nazanin Ghazanfari, Sonia Ghilas, Maria N de Menezes, Lauren E Holz, Cheng Huang, Kieran English, Myo Naung, Peck Szee Tan, Kirsteen M Tullett, Thiago M Steiner, Matthias H Enders, Lynette Beattie, Yu Cheng Chua, Claerwen M Jones, Anton Cozijnsen, Vanessa Mollard, Yeping Cai, David G Bowen

2020-06-10

Liver-resident memory CD8+ T (TRM) cells remain in and constantly patrol the liver to elicit rapid immunity upon antigen encounter..

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Hypersensitivities following allergen antigen recognition by unconventional T cells

Marcela de Lima Moreira, Michael NT Souter, Zhenjun Chen, Liyen Loh, James McCluskey, Daniel G Pellicci, Sidonia BG Eckle

2020-04-13

Conventional T cells recognise protein-derived antigens in the context of major histocompatibility complex (MHC) class Ia and clas..

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Virus-Mediated Suppression of the Antigen Presentation Molecule MR1

Brian P McSharry, Carolyn Samer, Hamish EG McWilliam, Caroline L Ashley, Michael B Yee, Megan Steain, Ligong Liu, David P Fairlie, Paul R Kinchington, James McCluskey, Allison Abendroth, Jose A Villadangos, Jamie Rossjohn, Barry Slobedman

2020-03-03

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The molecular basis underpinning the potency and specificity of MAIT cell antigens

Wael Awad, Geraldine JM Ler, Weijun Xu, Andrew N Keller, Jeffrey YW Mak, Xin Yi Lim, Ligong Liu, Sidonia BG Eckle, Jerome Le Nours, James McCluskey, Alexandra J Corbett, David P Fairlie, Jamie Rossjohn

2020-03-02

Mucosal-associated invariant T (MAIT) cells are activated by microbial riboflavin-based metabolite antigens when presented by MR1...

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Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

Michael D Crowther, Garry Dotlon, Mateusz Legut, Marine E Caillaud, Angharad Lloyd, Meriem Attaf, Sarah AE Galloway, Cristina Rius, Colin P Farrell, Barbara Szomolay, Ann Ager, Alan L Parker, Anna Fuller, Marco Donia, James McCluskey, Jamie Rossjohn, Inge Marie Svane, John D Phillips, Andrew K Sewell

2020-01-20

Human leukocyte antigen (HLA)-independent, T cell-mediated targeting of cancer cells would allow immune destruction of malignancie..

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T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease

Jan Petersen, Laura Ciacchi, Mai T Tran, Khai Lee Loh, Yvonne Kooy-Winkelaar, Nathan P Croft, Melinda Y Hardy, Zhenjun Chen, James McCluskey, Robert P Anderson, Anthony W Purcell, Jason A Tye-Din, Frits Koning, Hugh H Reid, Jamie Rossjohn

2019-12-23

The human leukocyte antigen (HLA) locus is strongly associated with T cell-mediated autoimmune disorders. HLA-DQ2.5-mediated celia..

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The biology and functional importance of MAIT cells

Dale Godfrey, Hui-Fern Koay, James McCluskey, Nicholas A Gherardin

2019-09-01

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Divergent SATB1 expression across human life span and tissue compartments

Simone Nussing, Hui-Fern Koay, Sneha Sant, Thomas Loudovaris, Stuart I Mannering, Martha Lappas, Yves d'Udekem, Igor E Konstantinov, Stuart P Berzins, Guus F Rimmelzwaan, Stephen J Turner, E Bridie Clemens, Dale I Godfrey, HO Nguyen Thi, Katherine Kedzierska

2019-05-01

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Human blood MAIT cell subsets defined using MR1 tetramers

Nicholas A Gherardin, Michael NT Souter, Hui-Fern Koay, Kirstie M Mangas, Torsten Seemann, Timothy P Stinear, Sidonia BG Eckle, Stuart P Berzins, Yves d'Udekem, Igor E Konstantinov, David P Fairlie, David S Ritchie, Paul J Neeson, Daniel G Pellicci, Adam P Uldrich, James McCluskey, Dale I Godfrey

2018-05-01

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Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma

Nicholas A Gherardin, Liyen Loh, Lorenztino Admojo, Alexander J Davenport, Kelden Richardson, Amy Rogers, Phillip K Darcy, Misty R Jenkins, H Miles Prince, Simon J Harrison, Hang Quach, David P Fairlie, Katherine Kedzierska, James McCluskey, Adam P Uldrich, Paul J Neeson, David S Ritchie, Dale I Godfrey

2018-03-07