SAVING BRAIN AND CHANGING PRACTICE IN STROKE
Grant number: 1113352 | Funding period: 2017 - 2021
Stroke outcomes directly relate to brain tissue rescue. We have contributed to changes in clinical practice through many clinical trials of new protocols and therapeutic strategies. Our program will focus on brain salvage in the pre-hospital setting and the acute hospital environment. We will use novel approaches to enhance brain recovery and design new implementation strategies to maximise the benefits of these therapeutic advances.
Related publications (7)
Hemispheric cortical atrophy and chronic microglial activation following mild focal ischemic stroke in adult male rats.
Charlotte M Ermine, Jess Nithianantharajah, Katrina O'Brien, Jessica A Kauhausen, Stefano Frausin, Alexander Oman, Mark W Parsons, Vanessa H Brait, Amy Brodtmann, Lachlan H Thompson
Animal modeling has played an important role in our understanding of the pathobiology of stroke. The vast majority of this researc..
Cognitive Recovery After Stroke: A Meta-analysis and Metaregression of Intervention and Cohort Studies
Juan Pablo Saa, Tamara Tse, Carolyn M Baum, Toby Cumming, Naomi Josman, Miranda Rose, Sophie O'Keefe, Katherine Sewell, Vinh Nguyen, Leeanne M Carey
BACKGROUND: Cognition affects poststroke recovery, but meta-analyses of cognition have not yet provided a comparison of observatio..
Longitudinal Stroke Recovery Associated With Dysregulation of Complement System-A Proteomics Pathway Analysis
Vinh A Nguyen, Nina Riddell, Sheila G Crewther, Pierre Faou, Harinda Rajapaksha, David W Howells, Graeme J Hankey, Tissa Wijeratne, Henry Ma, Stephen Davis, Geoffrey A Donnan, Leeanne M Carey
Currently the longitudinal proteomic profile of post-ischemic stroke recovery is relatively unknown with few well-accepted biomark..
Comparing Participation Outcome Over Time Across International Stroke Cohorts: Outcomes and Methods
Daan Verberne, Tamara Tse, Thomas Matyas, Carolyn Baum, Marcel Post, Leeanne Carey, Caroline van Heugten
OBJECTIVE: To enable a direct comparison of participation levels in the first year post-stroke, assessed by different outcome meas..
Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores
Peter Goodin, Gemma Lamp, Rishma Vidyasagar, Alan Connelly, Stephen Rose, Bruce C Campbell, Tamara Tse, Henry Ma, David Howells, Graeme J Hankey, Stephen Davis, Geoffrey Donnan, Leeanne M Carey
Background: One in three survivors of stroke experience poststroke depression (PSD). PSD has been linked with poorer recovery of f..
Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke
BCV Campbell, PJ Mitchell, L Churilov, N Yassi, TJ Kleinig, RJ Dowling, B Yan, SJ Bush, HM Dewey, V Thijs, R Scroop, M Simpson, M Brooks, H Asadi, TY Wu, DG Shah, T Wijeratne, T Ang, F Miteff, CR Levi
BACKGROUND: Intravenous infusion of alteplase is used for thrombolysis before endovascular thrombectomy for ischemic stroke. Tenec..