Pre-Clinical Assessment of the Therapeutic Potential of Targeting the Hippo Pathway in Muscle Wasting & Muscle-Derived Cancer
Grant number: 1099588 | Funding period: 2016 - 2019
Completed
Abstract
Recent findings have identified the Hippo signalling pathway as an important regulator of processes in muscle fibres and muscle progenitor cells. This project will look at the significance of the Hippo pathway in the development of muscle wasting caused by statin administration, and in the genesis of muscle derived tumors (rhabdomyosarcoma). The studies will determine if interventions that regulate the Hippo pathway could provide new therapies for these important muscle-related diseases.