ESTABLISHING AND VALIDATING A NEW THERPAUETIC TARGET FOR COLON AND STOMACH CANCER
Grant number: 1069024 | Funding period: 2016 - 2016
Cancers of the stomach and the colon are a major health burden. One of the central signaling molecules that drives these cancers is called Stat3. Here we propose to use a novel strain of mice that allows us to experimentally dial down the amount of Stat3 protein and hence to predict how effective a future anti-Stat3 cancer drug will be.
Related publications (19)
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Yan Qin, Carolyn Shembrey, Jai Smith, Sophie Paquet-Fifield, Corina Behrenbruch, Laura M Beyit, Benjamin NJ Thomson, Alexander G Heriot, Yuan Cao, Frederic Hollande
Remodeling of basement membrane proteins contributes to tumor progression towards the metastatic stage. One of these proteins, lam..
IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
Moritz F Eissmann, Christine Dijkstra, Andrew Jarnicki, Toby Phesse, Jamina Brunnberg, Ashleigh R Poh, Nima Etemadi, Evelyn Tsantikos, Stefan Thiem, Nicholas D Huntington, Margaret L Hibbs, Alex Boussioutas, Michele A Grimbaldeston, Michael Buchert, Robert JJ O'Donoghue, Frederick Masson, Matthias Ernst
The contribution of mast cells in the microenvironment of solid malignancies remains controversial. Here we functionally assess th..
Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.
Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar-Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael Dw Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand
Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in soli..
A Spatio-Temporal Model and Inference Tools for Longitudinal Count Data on Multicolor Cell Growth
PuXue Qiao, Christina Molck, Davide Ferrari, Frederic Hollande
Multicolor cell spatio-temporal image data have become important to investigate organ development and regeneration, malignant grow..
Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells
Sophie Paquet-Fifield, Shir Lin Koh, Lesley Cheng, Laura M Beyit, Carolyn Shembrey, Christina Molck, Corina Behrenbruch, Marina Papin, Meritxell Gironella, Sophie Guelfi, Ramona Nasr, Fanny Grillet, Michel Prudhomme, Jean-Francois Bourgaux, Antoni Castells, Jean-Marc Pascussi, Alexander G Heriot, Alain Puisieux, Melissa J Davis, Julie Pannequin
Posttreatment recurrence of colorectal cancer, the third most lethal cancer worldwide, is often driven by a subpopulation of cance..
Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture
Fanny Grillet, Elsa Bayet, Olivia Villeronce, Luke Zappia, Ebba Louise Lagerqvist, Sebastian Lunke, Emmanuelle Charafe-Jauffret, Kym Pham, Christina Molck, Nathalie Rolland, Jean Francois Bourgaux, Michel Prudhomme, Claire Philippe, Sophie Bravo, Jean Christophe Boyer, Lucile Canterel-Thouennon, Graham Roy Taylor, Arthur Hsu, Jean Marc Pascussi, Frederic Hollande
OBJECTIVE: Although counting of circulating tumour cells (CTC) has attracted a broad interest as potential markers of tumour progr..
Generation of an inducible mouse model to reversibly silence Stat3.
Mariah G Alorro, Thomas P Pierce, Moritz F Eissmann, Christine Dijkstra, Ross A Dickins, Matthias Ernst, Michael Buchert, Frederic Masson
Signal transducer and activator of transcription 3 (Stat3) is a transcription factor that has many essential roles during inflamma..
The A(2b) adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism
Christina Molck, James Ryall, Laura M Failla, Janine L Coates, Jean-Marc Pascussi, Joan K Heath, Gregory Stewart, Frederic Hollande
PURPOSE: Adenosine is a multifaceted regulator of tumor progression. It modulates immune cell activity as well as acting directly ..
Pregnane X-receptor promotes stem cell-mediated colon cancer relapse
Chris Planque, Fatemeh Rajabi, Fanny Grillet, Pascal Finetti, Francois Bertucci, Meritxell Gironella, Juan Jose Lozano, Bertrand Beucher, Julie Giraud, Veronique Garambois, Charles Vincent, Daniel Brown, Ludovic Caillo, Jovana Kantar, Andre Pelegrin, Michel Prudhomme, Jeremie Ripoche, Jean Francois Bourgaux, Christophe Ginestier, Antoni Castells
Colorectal cancer lethality usually results from post-treatment relapse in the majority of stage II-IV patients, due to the enhanc..
Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells
Julie Giraud, Laura M Failla, Jean-Marc Pascussi, Ebba L Lagerqvist, Jeremy Ollier, Pascal Finetti, Francois Bertucci, Chu Ya, Imene Gasmi, Jean-Francois Bourgaux, Michel Prudhomme, Thibault Mazard, Imade Ait-Arsa, Leila Houhou, Daniel Birnbaum, Andre Pelegrin, Charles Vincent, James G Ryall, Dominique Joubert, Julie Pannequin
Subpopulations of cancer stem-like cells (CSC) are thought to drive tumor progression and posttreatment recurrence in multiple sol..
Emerging roles for IL-11 signaling in cancer development and progression: Focus on breast cancer
Cameron N Johnstone, Ashwini Chand, Tracy L Putoczki, Matthias Ernst
Interleukin (IL)-11 is a member of the IL-6 family of cytokines that is defined by the shared use of the GP130 signal transducing ..