Multimodal retinal imaging provides 'insight' into cerebrovascular ageing
Grant number: LP160100126 | Funding period: 2016 - 2021
This project aims to develop a multi-modal imaging technology platform to simultaneously measure amyloid beta and its neurovascular sequelae to identify novel early biomarkers of ageing in the eye and brain. The growing ageing population is an increasing socioeconomic burden. The central nervous system is particularly susceptible to ageing, which is difficult to measure at its onset. Critically, as the eye is an easily accessible extension of the cortex, retinal imaging may be a non-invasive surrogate to assess ageing changes in the brain. Anticipated outcomes are a sensitive detector of neural ageing, improved preventative measures, reducing the socioeconomic burden of ageing, and improved ..View full description
Related publications (19)
Therapeutic applications of chelating drugs in iron metabolic disorders of the brain and retina
Ali Shahandeh, Bang V Bui, David I Finkelstein, Christine TO Nguyen
Iron is essential for normal cellular function, however, excessive accumulation of iron in neural tissue has been implicated in bo..
Tyro3 Contributes to Retinal Ganglion Cell Function, Survival and Dendritic Density in the Mouse Retina
Farrah Blades, Vickie HY Wong, Christine TO Nguyen, Bang V Bui, Trevor J Kilpatrick, Michele D Binder
Retinal ganglion cells (RGCs) are the only output neurons of the vertebrate retina, integrating signals from other retinal neurons..
Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer's Disease
Jeremiah KH Lim, Qiao-Xin Li, Zheng He, Algis J Vingrys, Holly R Chinnery, Jamie Mullen, Bang V Bui, Christine TO Nguyen
Alzheimer's disease is characterized by the aberrant deposition of protein in the brain and is the leading cause of dementia world..
Response of the Trilaminar Retinal Vessel Network to Intraocular Pressure Elevation in Rat Eyes
Da Zhao, Zheng He, Lin Wang, Brad Fortune, Jeremiah KH Lim, Vickie HY Wong, Christine TO Nguyen, Bang Bui
Purpose: The purpose of this study was to test the hypothesis that the superficial, intermediate, and deep retinal vascular plexus..
Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease
Xavier Hadoux, Flora Hui, Jeremiah KH Lim, Colin L Masters, Alice Pebay, Sophie Chevalier, Jason Ha, Samantha Loi, Christopher J Fowler, Christopher Rowe, Victor L Villemagne, Edward N Taylor, Christopher Fluke, Jean-Paul Soucy, Frederic Lesage, Jean-Philippe Sylvestre, Pedro Rosa-Neto, Sulantha Mathotaarachchi, Serge Gauthier, Ziad S Nasreddine
Progressive impairments in executive function in the APP/PS1 model of Alzheimer’s disease as measured by translatable touchscreen testing
A Shepherd, JKH Lim, VHY Wong, AM Zeleznikow-Johnston, L Churilov, CTO Nguyen, BV Bui, AJ Hannan, EL Burrows
Abstract Executive function deficits in Alzheimer’s disease (AD) occur early in disease progression and may be predictive of cogni..