Multimodal retinal imaging provides 'insight' into cerebrovascular ageing

Grant number: LP160100126 | Funding period: 2016 - 2021

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Abstract

This project aims to develop a multi-modal imaging technology platform to simultaneously measure amyloid beta and its neurovascular sequelae to identify novel early biomarkers of ageing in the eye and brain. The growing ageing population is an increasing socioeconomic burden. The central nervous system is particularly susceptible to ageing, which is difficult to measure at its onset. Critically, as the eye is an easily accessible extension of the cortex, retinal imaging may be a non-invasive surrogate to assess ageing changes in the brain. Anticipated outcomes are a sensitive detector of neural ageing, improved preventative measures, reducing the socioeconomic burden of ageing, and improved ..

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Related publications (22)

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Retinal hyperspectral imaging in the 5xFAD mouse model of Alzheimer's disease

Jeremiah KH Lim, Qiao-Xin Li, Tim Ryan, Phillip Bedggood, Andrew Metha, Algis J Vingrys, Bang Bui, Christine TO Nguyen

2021-03-18

Hyperspectral imaging of the retina has recently been posited as a potentially useful form of spectroscopy of amyloid-beta (Aβ) pr..

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Increased episcleral venous pressure in a mouse model of circumlimbal suture induced ocular hypertension

Vickie HY Wong, Da Zhao, Bang Bui, Cameron J Millar, Christine TO Nguyen

2021-01-01

PURPOSE: To investigate changes in aqueous humor dynamics during intraocular pressure (IOP) elevation induced by circumlimbal sutu..

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Therapeutic applications of chelating drugs in iron metabolic disorders of the brain and retina

Ali Shahandeh, Bang V Bui, David I Finkelstein, Christine TO Nguyen

2020-10-01

Iron is essential for normal cellular function, however, excessive accumulation of iron in neural tissue has been implicated in bo..

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Tyro3 Contributes to Retinal Ganglion Cell Function, Survival and Dendritic Density in the Mouse Retina

Farrah Blades, Vickie HY Wong, Christine TO Nguyen, Bang V Bui, Trevor J Kilpatrick, Michele D Binder

2020-08-14

Retinal ganglion cells (RGCs) are the only output neurons of the vertebrate retina, integrating signals from other retinal neurons..

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Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer's Disease

Jeremiah KH Lim, Qiao-Xin Li, Zheng He, Algis J Vingrys, Holly R Chinnery, Jamie Mullen, Bang V Bui, Christine TO Nguyen

2020-08-13

Alzheimer's disease is characterized by the aberrant deposition of protein in the brain and is the leading cause of dementia world..

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Tyro3 is a key regulator of myelin structure and retinal function in the central nervous system

F Blades, VHY Wong, CTON Nguyen, BV Bui, TJ Kilpatrick, MD Binder

2020-03-01

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Response of the Trilaminar Retinal Vessel Network to Intraocular Pressure Elevation in Rat Eyes

Da Zhao, Zheng He, Lin Wang, Brad Fortune, Jeremiah KH Lim, Vickie HY Wong, Christine TO Nguyen, Bang Bui

2020-02-01

Purpose: The purpose of this study was to test the hypothesis that the superficial, intermediate, and deep retinal vascular plexus..

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Age-Specific Retinal and Cerebral Immunodetection of Amyloid-beta Plaques and Oligomers in a Rodent Model of Alzheimer's Disease

Umma Habiba, Sam Merlin, Jeremiah KH Lim, Vickie HY Wong, Christine TO Nguyen, John W Morley, Bang Bui, Mourad Tayebi

2020-01-01

BACKGROUND: Amyloid-β soluble oligomers (Aβo) are believed to be the cause of the pathophysiology underlying Alzheimer's disease (..

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A retinal imaging biomarker of Alzheimer's disease

Peter van Wijngaarden, Xavier Hadoux, Flora Hui, Jeremiah Lim, Christine Nguyen, Bang Bui, Jonathan Crowston

2019-11-01

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Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease

Xavier Hadoux, Flora Hui, Jeremiah KH Lim, Colin L Masters, Alice Pebay, Sophie Chevalier, Jason Ha, Samantha Loi, Christopher J Fowler, Christopher Rowe, Victor L Villemagne, Edward N Taylor, Christopher Fluke, Jean-Paul Soucy, Frederic Lesage, Jean-Philippe Sylvestre, Pedro Rosa-Neto, Sulantha Mathotaarachchi, Serge Gauthier, Ziad S Nasreddine

2019-09-17

Studies of rodent models of Alzheimer's disease (AD) and of human tissues suggest that the retinal changes that occur in AD, inclu..

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Reversibility of Retinal Ganglion Cell Dysfunction From Chronic IOP Elevation

Da Zhao, Vickie HY Wong, Christine TO Nguyen, Andrew I Jobling, Erica L Fletcher, Algis J Vingrys, Bang V Bui

2019-09-01

Purpose: To test the hypothesis that the capacity for retinal ganglion cells to functionally recover from chronic IOP elevation is..

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Progressive impairments in executive function in the APP/PS1 model of Alzheimer’s disease as measured by translatable touchscreen testing

A Shepherd, JKH Lim, VHY Wong, AM Zeleznikow-Johnston, L Churilov, CTO Nguyen, BV Bui, AJ Hannan, EL Burrows

2019-08-21

Abstract Executive function deficits in Alzheimer’s disease (AD) occur early in disease progression and may be predictive of cogni..

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Evaluating retinal biomarkers in a mouse model of Parkinson's disease

Christine Tram Oanh Nguyen, Katie Tran, Jeremiah Kah Heng Lim, Vickie Hoi Ying Wong, Ali Shahandeh, Algis J Vingrys, Bang V Bui, David Finkelstein

2019-07-01

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The effect of TrkB receptor knockdown on mouse retinal ganglion cell function and their response to acute mild intraocular pressure stress

Vickie Hoi Ying Wong, Amy Wang, Christine Tram Oanh Nguyen, Jeremiah Kah Heng Lim, Madeline Nicholson, Junhua Xiao, Simon Murray, Bang V Bui

2019-07-01

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Morphological changes to retinal ganglion cells in a murine model of Alzheimer's disease

Vickie Wong, Christine Tram Oanh Nguyen, Patricia Jusuf, Jeremiah KH Lim, Mourad Tayebi, Bang V Bui

2018-07-01

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Reversibility of retinal ganglion cell dysfunction due to chronic IOP elevation.

Da Zhao, Vickie Hoi Ying Wong, Zheng He, Christine Tram Oanh Nguyen, Andrew Ian Jobling, Erica Fletcher, Holly Chinnery, Patricia Jusuf, Jeremiah KH Lim, Algis J Vingrys, Bang V Bui

2018-07-01

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Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model

Anna K van Koeverden, Zheng He, Christine TO Nguyen, Algis J Vingrys, Bang V Bui

2018-05-08

High intraocular pressure is the most well documented glaucoma risk factor; however many patients develop and/or show progression ..

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Age-related changes in the response of retinal structure, function and blood flow to pressure modification in rats

Da Zhao, Christine TO Nguyen, Zheng He, Vickie HY Wong, Anna K van Koeverden, Algis J Vingrys, Bang V Bui

2018-02-13

Age-related changes to the balance between the pressure inside the eye (intraocular pressure, IOP) and the pressure inside the bra..

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Retinal structural and functional changes in mouse models of Alzheimer’s and Parkinson’s disease

Christine Tram Oanh Nguyen, Jeremiah Lim, Vickie Wong, Bang Viet Bui, Algis Vingrys, Jamie Mullen, David Finkelstein

2018-01-01

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Retinal and Cortical Blood Flow Dynamics Following Systemic Blood-Neural Barrier Disruption

Flora Hui, Christine TO Nguyen, Zheng He, Algis J Vingrys, Rachel Gurrell, Rebecca L Fish, Bang V Bui

2017-10-12

To consider whether imaging retinal vasculature may be used as a marker for cortical vessels, we compared fluorescein angiography ..

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Retinal biomarkers provide "insight" into cortical pharmacology and disease

Christine TO Nguyen, Flora Hui, Jason Charng, Shajan Velaedan, Anna K van Koeverden, Jeremiah KH Lim, Zheng He, Vickie HY Wong, Algis J Vingrys, Bang V Bui, Magnus Ivarsson

2017-07-01

The retina is an easily accessible out-pouching of the central nervous system (CNS) and thus lends itself to being a biomarker of ..

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The Eye As a Biomarker for Alzheimer's Disease

Jeremiah KH Lim, Qiao-Xin Li, Zheng He, Algis J Vingrys, Vickie HY Wong, Nicolas Currier, Jamie Mullen, Bang V Bui, Christine TO Nguyen

2016-11-17

Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia and eventual death. It is the leading c..

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