Multimodal retinal imaging provides 'insight' into cerebrovascular ageing
Grant number: LP160100126 | Funding period: 2016 - 2021
This project aims to develop a multi-modal imaging technology platform to simultaneously measure amyloid beta and its neurovascular sequelae to identify novel early biomarkers of ageing in the eye and brain. The growing ageing population is an increasing socioeconomic burden. The central nervous system is particularly susceptible to ageing, which is difficult to measure at its onset. Critically, as the eye is an easily accessible extension of the cortex, retinal imaging may be a non-invasive surrogate to assess ageing changes in the brain. Anticipated outcomes are a sensitive detector of neural ageing, improved preventative measures, reducing the socioeconomic burden of ageing, and improved ..View full description
Related publications (22)
Retinal hyperspectral imaging in the 5xFAD mouse model of Alzheimer's disease
Jeremiah KH Lim, Qiao-Xin Li, Tim Ryan, Phillip Bedggood, Andrew Metha, Algis J Vingrys, Bang Bui, Christine TO Nguyen
Hyperspectral imaging of the retina has recently been posited as a potentially useful form of spectroscopy of amyloid-beta (Aβ) pr..
Increased episcleral venous pressure in a mouse model of circumlimbal suture induced ocular hypertension
Vickie HY Wong, Da Zhao, Bang Bui, Cameron J Millar, Christine TO Nguyen
PURPOSE: To investigate changes in aqueous humor dynamics during intraocular pressure (IOP) elevation induced by circumlimbal sutu..
Therapeutic applications of chelating drugs in iron metabolic disorders of the brain and retina
Ali Shahandeh, Bang V Bui, David I Finkelstein, Christine TO Nguyen
Iron is essential for normal cellular function, however, excessive accumulation of iron in neural tissue has been implicated in bo..
Tyro3 Contributes to Retinal Ganglion Cell Function, Survival and Dendritic Density in the Mouse Retina
Farrah Blades, Vickie HY Wong, Christine TO Nguyen, Bang V Bui, Trevor J Kilpatrick, Michele D Binder
Retinal ganglion cells (RGCs) are the only output neurons of the vertebrate retina, integrating signals from other retinal neurons..
Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer's Disease
Jeremiah KH Lim, Qiao-Xin Li, Zheng He, Algis J Vingrys, Holly R Chinnery, Jamie Mullen, Bang V Bui, Christine TO Nguyen
Alzheimer's disease is characterized by the aberrant deposition of protein in the brain and is the leading cause of dementia world..
Response of the Trilaminar Retinal Vessel Network to Intraocular Pressure Elevation in Rat Eyes
Da Zhao, Zheng He, Lin Wang, Brad Fortune, Jeremiah KH Lim, Vickie HY Wong, Christine TO Nguyen, Bang Bui
Purpose: The purpose of this study was to test the hypothesis that the superficial, intermediate, and deep retinal vascular plexus..
Age-Specific Retinal and Cerebral Immunodetection of Amyloid-beta Plaques and Oligomers in a Rodent Model of Alzheimer's Disease
Umma Habiba, Sam Merlin, Jeremiah KH Lim, Vickie HY Wong, Christine TO Nguyen, John W Morley, Bang Bui, Mourad Tayebi
BACKGROUND: Amyloid-β soluble oligomers (Aβo) are believed to be the cause of the pathophysiology underlying Alzheimer's disease (..
Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease
Xavier Hadoux, Flora Hui, Jeremiah KH Lim, Colin L Masters, Alice Pebay, Sophie Chevalier, Jason Ha, Samantha Loi, Christopher J Fowler, Christopher Rowe, Victor L Villemagne, Edward N Taylor, Christopher Fluke, Jean-Paul Soucy, Frederic Lesage, Jean-Philippe Sylvestre, Pedro Rosa-Neto, Sulantha Mathotaarachchi, Serge Gauthier, Ziad S Nasreddine
Studies of rodent models of Alzheimer's disease (AD) and of human tissues suggest that the retinal changes that occur in AD, inclu..
Reversibility of Retinal Ganglion Cell Dysfunction From Chronic IOP Elevation
Da Zhao, Vickie HY Wong, Christine TO Nguyen, Andrew I Jobling, Erica L Fletcher, Algis J Vingrys, Bang V Bui
Purpose: To test the hypothesis that the capacity for retinal ganglion cells to functionally recover from chronic IOP elevation is..
Progressive impairments in executive function in the APP/PS1 model of Alzheimer’s disease as measured by translatable touchscreen testing
A Shepherd, JKH Lim, VHY Wong, AM Zeleznikow-Johnston, L Churilov, CTO Nguyen, BV Bui, AJ Hannan, EL Burrows
Abstract Executive function deficits in Alzheimer’s disease (AD) occur early in disease progression and may be predictive of cogni..
Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model
Anna K van Koeverden, Zheng He, Christine TO Nguyen, Algis J Vingrys, Bang V Bui
High intraocular pressure is the most well documented glaucoma risk factor; however many patients develop and/or show progression ..
Age-related changes in the response of retinal structure, function and blood flow to pressure modification in rats
Da Zhao, Christine TO Nguyen, Zheng He, Vickie HY Wong, Anna K van Koeverden, Algis J Vingrys, Bang V Bui
Age-related changes to the balance between the pressure inside the eye (intraocular pressure, IOP) and the pressure inside the bra..
Retinal and Cortical Blood Flow Dynamics Following Systemic Blood-Neural Barrier Disruption
Flora Hui, Christine TO Nguyen, Zheng He, Algis J Vingrys, Rachel Gurrell, Rebecca L Fish, Bang V Bui
To consider whether imaging retinal vasculature may be used as a marker for cortical vessels, we compared fluorescein angiography ..
Retinal biomarkers provide "insight" into cortical pharmacology and disease
Christine TO Nguyen, Flora Hui, Jason Charng, Shajan Velaedan, Anna K van Koeverden, Jeremiah KH Lim, Zheng He, Vickie HY Wong, Algis J Vingrys, Bang V Bui, Magnus Ivarsson
The retina is an easily accessible out-pouching of the central nervous system (CNS) and thus lends itself to being a biomarker of ..
The Eye As a Biomarker for Alzheimer's Disease
Jeremiah KH Lim, Qiao-Xin Li, Zheng He, Algis J Vingrys, Vickie HY Wong, Nicolas Currier, Jamie Mullen, Bang V Bui, Christine TO Nguyen
Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia and eventual death. It is the leading c..