Sticky cells: Understanding and modeling platelet flow and binding in blood
Grant number: LP160100786 | Funding period: 2016 - 2021
This project aims to predict how platelets flow through vascular scale geometries, using an experimental and numerical development programme. Platelets maintain a healthy vascular system. Like other cells, they respond to local stimuli: the concentration of chemical agonists, bonds with neighbouring species, fluid dynamic stresses, and even their history. On a single cell level, many of these biophysical processes are not understood or quantified. At the blood vessel level, multiscale modelling techniques cannot translate this single cell knowledge to capture how collections of platelets behave. This project is expected to lead to better therapies for cardiovascular disease and a new class o..View full description
Related publications (2)
Lift and drag forces acting on a particle moving with zero slip in a linear shear flow near a wall
NIK Ekanayake, JD Berry, AD Stickland, DE Dunstan, IL Muir, SK Dower, DJE Harvie
The lift and drag forces acting on a small spherical particle in a single wall-bounded linear shear flow are examined via numerica..