NOVEL APPROACH TO TREATMENT OF HER2+ BREAST CANCERS WITH POOR PROGNOSIS

Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network

Sue Haupt, Franco Caramia, Alan Herschtal, Thierry Soussi, Guillermina Lozano, Hu Chen, Han Liang, Terence P Speed, Ygal Haupt

2019-11-26

The disproportionately high prevalence of male cancer is poorly understood. We tested for sex-disparity in the functional integrit..

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

Alex RD Delbridge, Andrew J Kueh, Francine Ke, Natasha M Zamudio, Farrah El-Saafin, Natasha Jansz, Gao-Yuan Wang, Megan Iminitoff, Tamara Beck, Sue Haupt, Yifang Hu, Rose E May, Lachlan Whitehead, Lin Tai, William Chiang, Marco J Herold, Ygal Haupt, Gordon K Smyth, Tim Thomas, Marnie E Blewitt

2019-04-09

Neural tube defects (NTDs) are common birth defects in humans and show an unexplained female bias. Female mice lacking the tumor s..

The long and the short of it: the MDM4 tail so far

Sue Haupt, Javier Octavio Mejia-Hernandez, Reshma Vijayakumaran, Simon P Keam, Ygal Haupt

2019-03-01

The mouse double minute 4 (MDM4) is emerging from the shadow of its more famous relative MDM2 and is starting to steal the limelig..

MDM4 is a rational target for treating breast cancers with mutant p53

Panimaya Jeffreena Miranda, Daniel Buckley, Dinesh Raghu, Jia-Min B Pang, Elena A Takano, Reshma Vijayakumaran, Amina FAS Teunisse, Atara Posner, Tahlia Procter, Marco J Herold, Cristina Gamell, Jean-Christophe Marine, Stephen B Fox, Aart Jochemsen, Sue Haupt, Ygal Haupt

2017-04-01

Mutation of the key tumour suppressor p53 defines a transition in the progression towards aggressive and metastatic breast cancer ..

The role of MDM2 and MDM4 in breast cancer development and prevention

Sue Haupt, Reshma Vijayakumaran, Panimaya Jeffreena Miranda, Andrew Burgess, Elgene Lim, Ygal Haupt

2017-02-01

The major cause of death from breast cancer is not the primary tumour, but relapsing, drug-resistant, metastatic disease. Identify..

P53 at the start of the 21st century: lessons from elephants.

Sue Haupt, Ygal Haupt

2017-01-01

Crucial, natural protection against tumour onset in humans is orchestrated by the dynamic protein p53. The best-characterised func..

Mutant p53 Drives Cancer by Subverting Multiple Tumor Suppression Pathways

Sue Haupt, Dinesh Raghu, Ygal Haupt

2016-01-27

The tumor suppressor p53 normally acts as a brake to halt damaged cells from perpetrating their genetic errors into future generat..