ROLE OF INTRINSIC VERSUS EXTRINSIC CUES IN CELL TYPE DETERMINATION DURING DEVELOPMENT AND REGENERATION

Grant number: DE120101311 | Funding period: 2016 - 2017

Completed

Abstract

During development all of the different cell types are generated by the action of genes and also signals from the embryo that read out which cell types are present or missing. This project studies how much environmental signals affect cell type generation developmentally and if they can be used to regenerate only the types missing in different diseases.

Related publications (6)

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Developmental and adult characterization of secretagogin expressing amacrine cells in zebrafish retina

Stefanie Dudczig, Peter David Currie, Patricia Regina Jusuf

2017-09-26

Calcium binding proteins show stereotypical expression patterns within diverse neuron types across the central nervous system. Her..

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Fate bias during neural regeneration adjusts dynamically without recapitulating developmental fate progression

Jeremy Ng Chi Kei, Peter David Currie, Patricia Regina Jusuf

2017-07-13

BACKGROUND: Regeneration of neurons in the central nervous system is poor in humans. In other vertebrates neural regeneration does..

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In vivo expression of Nurr1/Nr4a2a in developing retinal amacrine subtypes in zebrafish Tg(nr4a2a:eGFP) transgenics

Liana Goodings, Jie He, Alasdair J Wood, William A Harris, Peter D Currie, Patricia R Jusuf

2017-06-01

The Nuclear receptor subfamily 4 group A member 2 (Nr4a2) is crucial for the formation or maintenance of dopaminergic neurons in t..

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In Vivo Imaging of Transgenic Gene Expression in Individual Retinal Progenitors in Chimeric Zebrafish Embryos to Study Cell Nonautonomous Influences

Stefanie Dudczig, Peter D Currie, Lucia Poggi, Patricia R Jusuf

2017-03-01

The genetic and technical strengths have made the zebrafish vertebrate a key model organism in which the consequences of gene mani..

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Feedback from each retinal neuron population drives expression of subsequent fate determinant genes without influencing the cell cycle exit timing

Jeremy Ng Chi Kei, Stefanie Dudczig, Peter D Currie, Patricia R Jusuf

2016-09-01

During neurogenesis, progenitors balance proliferation and cell cycle exit together with expression of fate determinant genes to e..

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The Regenerative Potential of the Vertebrate Retina: Lessons from the Zebrafish

Jeremy Ng, Peter D Currie, Patricia R Jusuf

2014-01-01

Regenerative. Potential. of. the. Vertebrate. Retina: Lessons. from. the. Zebrafish. Jeremy Ng, Peter D. Currie, and Patricia R. ..

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