New drugs against parasitic nematodes of livestock animals

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

Sarah Preston, Pasi K Korhonen, Laurent Mouchiroud, Matteo Cornaglia, Sean L McGee, Neil D Young, Rohan A Davis, Simon Crawford, Cameron Nowell, Brendan RE Ansell, Gillian M Fisher, Katherine T Andrews, Bill CH Chang, Martin AM Gijs, Paul W Sternberg, Johan Auwerx, Jonathan Baell, Andreas Hofmann, Abdul Jabbar, Robin B Gasser

2017-10-01

As a result of limited classes of anthelmintics and an over-reliance on chemical control, there is a great need to discover new co..

Screening of the 'Stasis Box' identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus

Yaqing Jiao, Sarah Preston, Anson V Koehler, Andreas J Stroehlein, Bill CH Chang, Kaylene J Simpson, Karla J Cowley, Michael J Palmer, Benoit Laleu, Timothy NC Wells, Abdul Jabbar, Robin B Gasser

2017-07-05

BACKGROUND: In partnership with the Medicines for Malaria Venture (MMV), we screened a collection ('Stasis Box') of 400 compounds ..

Ascaris phylogeny based on multiple whole mtDNA genomes

Peter Nejsuma, Mohamed BF Hawash, Martha Betson, J Russell Stothard, Robin B Gasser, Lee O Andersen

2017-03-01

Ascaris lumbricoides and A. suum are two parasitic nematodes infecting humans and pigs, respectively. There has been considerable ..

Assessing the performance of multiplexed tandem PCR for the diagnosis of pathogenic genotypes of Theileria orientalis using pooled blood samples from cattle

Hagos Gebrekidan, Robin B Gasser, Mark A Stevenson, Sean McGrath, Abdul Jabbar

2017-02-01

Oriental theileriosis caused by multiple genotypes of Theileria orientalis is an important tick-borne disease of bovines. Here, we..

Molecular characterisation of Theileria orientalis in imported and native bovines from Pakistan

Hagos Gebrekidan, Tariq Abbas, Muhammad Wajid, Aamir Ali, Robin B Gasser, Abdul Jabbar

2017-01-01

The epidemiological aspects of Theileria orientalis in Pakistan are unknown; therefore, investigations using sensitive and precise..

Organometallic Derivatization of the Nematocidal Drug Monepantel Leads to Promising Antiparasitic Drug Candidates

Jeannine Hess, Malay Patra, Loganathan Rangasamy, Sandro Konatschnig, Olivier Blacque, Abdul Jabbar, Patrick Mac, Erik M Jorgensen, Robin B Gasser, Gilles Gasser

2016-11-01

The discovery of novel drugs against animal parasites is in high demand due to drug-resistance problems encountered around the wor..

Genomic resources for a unique, low-virulence Babesia taxon from China

Guiquan Guan, Pasi K Korhonen, Neil D Young, Anson V Koehler, Tao Wang, Youquan Li, Zhijie Liu, Jianxun Luo, Hong Yin, Robin B Gasser

2016-10-27

BACKGROUND: Babesiosis is a socioeconomically important tick-borne disease of animals (including humans) caused by haemoprotozoan ..

Synthesis, Characterization, and Biological Activity of Ferrocenyl Analogues of the Anthelmintic Drug Monepantel

Jeannine Hess, Malay Patra, Vanessa Pierroz, Bernhard Spingler, Abdul Jabbar, Stefano Ferrari, Robin B Gasser, Gilles Gasser

2016-10-10

There is major demand for the development of structurally new anti-infectives using innovative approaches to circumvent multidrug ..

Molecular characterization of species of Cloacina (Strongyloidea: Cloacininae) from the common wallaroo, Macropus robustus (Marsupialia: Macropodidae) in Australia

Mary A Shuttleworth, Ian Beveridge, Anson V Koehler, Robin B Gasser, Abdul Jabbar

2016-10-01

This study examined genetic variation within and among species of Cloacina found in the common wallaroo (Macropus robustus) collec..

Detection of cryptic species of Rugopharynx (Nematoda: Strongylida) from the stomachs of Australian macropodid marsupials

Neil B Chilton, Florence Huby-Chilton, Anson V Koehler, Robin B Gasser, Ian Beveridge

2016-08-01

Sequences of the internal transcribed spacers of nuclear ribosomal DNA (ITS-1 and ITS-2) were determined for species of the genus ..

Time-Course Study of the Transcriptome of Peripheral Blood Mononuclear Cells (PBMCs) from Sheep Infected with Fasciola hepatica

Cristian A Alvarez Rojas, Jean-Pierre Scheerlinck, Brendan RE Ansell, Ross S Hall, Robin B Gasser, Aaron R Jex

2016-07-20

Fasciola hepatica is a parasitic trematode that infects a wide range of mammalian hosts, including livestock and humans, in temper..

A perspective on genomic-guided anthelmintic discovery and repurposing using Haemonchus contortus

Sarah Preston, Abdul Jabbar, Robin B Gasser

2016-06-01

High-throughput molecular and computer technologies have become instrumental for systems biological explorations of parasites. Inv..

Phylogenetic relationships of species of the oesophageal parasitic nematode genera Cyclostrongylus and Spirostrongylus (Strongyloidea: Chabertiidae: Cloacininae) with their wallaby hosts (Marsupialia: Macropodidae)

Neil B Chilton, Florence Huby-Chilton, Anson V Koehler, Robin B Gasser, Ian Beveridge

2016-04-01

A phylogeny for seven species of Cyclostrongylus and the monotypic genus Spirostrongylus (Nematoda: Chabertiidae), all highly host..

Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention

Samantha N McNulty, Christina Struebe, Bruce A Rosa, John C Martin, Rahul Tyagi, Young-Jun Choi, Qi Wang, Kymberlie Hallsworth Pepin, Xu Zhang, Philip Ozersky, Richard K Wilson, Paul W Sternberg, Robin B Gasser, Makedonka Mitreva

2016-02-09

The bovine lungworm, Dictyocaulus viviparus (order Strongylida), is an important parasite of livestock that causes substantial eco..

Molecular analysis of Cryptosporidium from cattle from five states of Peninsular Malaysia

Nan Jiun Yap, Anson V Koehler, Janine Ebner, Tiong Kai Tan, Yvonne AL Lim, Robin B Gasser

2016-02-01

Despite the importance of the cattle industry in Malaysia, there are very few studies of the diversity and public health significa..

Assessment of the nematocidal activity of metallocenyl analogues of monepantel

Jeannine Hess, Malay Patra, Abdul Jabbar, Vanessa Pierroz, Sandro Konatschnig, Bernhard Spingler, Stefano Ferrari, Robin B Gasser, Gilles Gasser

2016-01-01

In this study, we present the design, synthesis, characterization and biological evaluation of structurally new ferrocenyl and rut..

Harnessing the Toxocara Genome to Underpin Toxocariasis Research and New Interventions

Robin B Gasser, Pasi K Korhonen, Xing-Quan Zhux, Neil D Young

2016-01-01

Parasitic worms, such as flatworms (platyhelminths) and roundworms (nematodes), cause substantial morbidity and mortality in anima..

Recent Advances in Elucidating Nematode Moulting - Prospects of Using Oesophagostomum dentatum as a Model

Martina Ondrovics, Robin B Gasserx, Anja Joachim

2016-01-01

There are major gaps in our knowledge of many molecular biological processes that take place during the development of parasitic n..