CLINICAL AND GENOMIC ASPECTS OF STAPHYLOCOCCUS AUREUS AND OTHER INFECTIOUS DISEASES IN NORTHERN AUSTRALIA
Grant number: 1065736 | Funding period: 2016 - 2017
The burden of infectious disease is high in Indigenous populations in northern Australia and patterns of disease differ. My research proposes to deepen our understanding of infectious diseases such as that due to Staphylococcus aureus (golden staph), hepatitis B and influenza by applying cutting-edge technologies (e.g., bacterial genomics) to answer clinically relevant questions. Ultimately I hope to prevent transmission of infections, improve vaccine strategies and find better targets for treatment.
Related publications (29)
Epidemiological consequences of enduring strain-specific immunity requiring repeated episodes of infection
Rebecca H Chisholm, Nikki Sonenberg, Jake A Lacey, Malcolm I McDonald, Manisha Pandey, Mark R Davies, Steven YC Tong, Jodie McVernon, Nicholas Geard
Group A Streptococcus (GAS) skin infections are caused by a diverse array of strain types and are highly prevalent in disadvantage..
Benzylpenicillin versus flucloxacillin for penicillin-susceptible Staphylococcus aureus bloodstream infections from a large retrospective cohort study
A Henderson, P Harris, G Hartel, D Paterson, J Turnidge, JS Davis, SYC Tong
In clinical practice, differing opinion exists as to the optimal management of patients with penicillin susceptible Staphylococcus..
Gene exchange drives the ecological success of a multi-host bacterial pathogen
Emily J Richardson, Rodrigo Bacigalupe, Ewan M Harrison, Lucy A Weinert, Samantha Lycett, Manouk Vrieling, Kirsty Robb, Paul A Hoskisson, Matthew TG Holden, Edward J Feil, Gavin K Paterson, Steven YC Tong, Adebayo Shittu, Willem van Wamel, David M Aanensen, Julian Parkhill, Sharon J Peacock, Jukka Corander, Mark Holmes, J Ross Fitzgerald
Indigenous Australian household structure: a simple data collection tool and implications for close contact transmission of communicable diseases
Thiripura vino, Gurmeet R Singh, Belinda Davision, Patricia T Campbell, Michael J Lydeamore, Andrew Robinson, Jodie McVernon, Steven YC Tong, Nicholas Geard
Proposed primary endpoints for use in clinical trials that compare treatment options for bloodstream infection in adults: a consensus definition
PNA Harris, JF McNamara, DC Lye, JS Davis, L Bernard, AC Cheng, Y Doi, VG Fowler, KS Kaye, L Leibovici, J Lipman, MJ Llewelyn, S Munoz-Price, M Paul, AY Peleg, J Rodriguez-Bano, BA Rogers, H Seifert, V Thamlikitkul, G Thwaites
CAMERA2-combination antibiotic therapy for methicillin-resistant Staphylococcus aureus infection: study protocol for a randomised controlled trial
Steven YC Tong, Jane Nelson, David L Paterson, Vance G Fowler, Benjamin P Howden, Allen C Cheng, Mark Chatfield, Jeffrey Lipman, Sebastian Van Hal, Matthew O'Sullivan, James O Robinson, Dafna Yahav, David Lye, Joshua S Davis
Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages
Patiyan Andersson, Simon R Harris, Helena MB Seth Smith, James Hadfield, Colette O'Neill, Lesley T Cutcliffe, Fiona P Douglas, L Valerie Asche, John D Mathews, Susan I Hutton, Derek S Sarovich, Steven YC Tong, Ian N Clarke, Nicholas R Thomson, Philip M Giffard
Chlamydia trachomatis genotypes in a cross-sectional study of urogenital samples from remote Northern and Central Australia
Philip M Giffard, Nicole C Brenner, Sepehr N Tabrizi, Suzanne M Garland, Deborah C Holt, Patiyan Andersson, Rachael A Lilliebridge, Steven YC Tong, Mandad Karimi, Prudence Boylan, Nathan Ryder, Tracy Johns, Gurmeet Singh
Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus
Eike J Steinig, Patiyan Andersson, Simon R Harris, Derek S Sarovich, Anand Manoharan, Paul Coupland, Matthew TG Holden, Julian Parkhill, Stephen D Bentley, D Ashley Robinson, Steven YC Tong
Genome sequencing defines phylogeny and spread of methicillin-resistant Staphylococcus aureus in a high transmission setting
Steven YC Tong, Matthew TG Holden, Emma K Nickerson, Ben S Cooper, Claudio U Koeser, Anne Cori, Thibaut Jombart, Simon Cauchemez, Christophe Fraser, Vanaporn Wuthiekanun, Janjira Thaipadungpanit, Maliwan Hongsuwan, Nicholas P Day, Direk Limmathurotsakul, Julian Parkhill, Sharon J Peacock
Novel staphylococcal species that form part of a Staphylococcus aureus-related complex: the non-pigmented Staphylococcus argenteus sp nov and the non-human primate-associated Staphylococcus schweitzeri sp nov.
Steven YC Tong, Frieder Schaumburg, Matthew J Ellington, Jukka Corander, Bruno Pichon, Fabian Leendertz, Stephen D Bentley, Julian Parkhill, Deborah C Holt, Georg Peters, Philip M Giffard
Short-course oral co-trimoxazole versus intramuscular benzathine benzylpenicillin for impetigo in a highly endemic region: an open-label, randomised, controlled, non-inferiority trial
Asha C Bowen, Steven YC Tong, Ross M Andrews, Irene M O'Meara, Malcolm I McDonald, Mark D Chatfield, Bart J Currie, Jonathan R Carapetis