THE RECENTLY DISCOVERED (PRO)RENIN RECEPTOR: EXAMINATION OF ITS ROLE IN DIABETES AND HEART DISEASE
Grant number: 1037633 | Funding period: 2016 - 2017
It is thought that a protein known as the (pro)renin receptor may cause cardiovascular disease, however little is known about its role in normal cell function. My project will investigate the normal function of this protein and determine what role it has in cardiovascular disease. This information will be essential for the development of new drugs. I will be conducting this research in a prestigious overseas laboratory, where I will learn new skills that I can bring with me back to Australia.
Related publications (11)
Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic beta cells
Katrina J Binger, Martin Neukam, Sudhir Gopal Tattikota, Fatimunnisa Qadri, Dmytro Puchkov, Diana M Willmes, Sabrina Wurmsee, Sabrina Geisberger, Ralf Dechend, Klemens Raile, Thomas Kurth, Genevieve Nguyen, Matthew N Poy, Michele Solimena, Dominik N Muller, Andreas L Birkenfeld
Pancreatic β cells store insulin within secretory granules which undergo exocytosis upon elevation of blood glucose levels. Crinop..
Immunometabolic Regulation of Interleukin-17-Producing T Helper Cells: Uncoupling New Targets for Autoimmunity
Katrina J Binger, Beatriz F Corte-Real, Markus Kleinewietfeld
Interleukin-17-producing T helper (Th17) cells are critical for the host defense of bacterial and fungal pathogens and also play a..
Elementary immunology: Na as a regulator of immunity
Valentin Schatz, Patrick Neubert, Agnes Schroeder, Katrina Binger, Matthias Gebhard, Dominik N Mueller, Friedrich C Luft, Jens Titze, Jonathan Jantsch
The skin can serve as an interstitial Na+ reservoir. Local tissue Na+ accumulation increases with age, inflammation and infection...
High salt reduces the activation of IL-4-and IL-13-stimulated macrophages
Katrina J Binger, Matthias Gebhardt, Matthias Heinig, Carola Rintisch, Agnes Schroeder, Wolfgang Neuhofer, Karl Hilgers, Arndt Manzel, Christian Schwartz, Markus Kleinewietfeld, Jakob Voelkl, Valentin Schatz, Ralf A Linker, Florian Lang, David Voehringer, Mark D Wright, Norbert Hubner, Ralf Dechend, Jonathan Jantsch, Jens Titze
A high intake of dietary salt (NaCl) has been implicated in the development of hypertension, chronic inflammation, and autoimmune ..
New role for the (pro)renin receptor in T-cell development
Sabrina Geisberger, Ulrike Maschke, Matthias Gebhardt, Markus Kleinewietfeld, Arndt Manzel, Ralf A Linker, Ann Chidgey, Ralf Dechend, Genevieve Nguyen, Oliver Daumke, Dominik N Muller, Mark D Wright, Katrina J Binger
The (pro)renin receptor (PRR) was originally thought to be important for regulating blood pressure via the renin-angiotensin syste..
Cutaneous Na Storage Strengthens the Antimicrobial Barrier Function of the Skin and Boosts Macrophage-Driven Host Defense
Jonathan Jantsch, Valentin Schatz, Diana Friedrich, Agnes Schroeder, Christoph Kopp, Isabel Siegert, Andreas Maronna, David Wendelborn, Peter Linz, Katrina J Binger, Matthias Gebhardt, Matthias Heinig, Patrick Neubert, Fabian Fischer, Stefan Teufel, Jean-Pierre David, Clemens Neufert, Alexander Cavallaro, Natalia Rakova, Christoph Kueper
Immune cells regulate a hypertonic microenvironment in the skin; however, the biological advantage of increased skin Na(+) concent..
Bcl10 Mediates Angiotensin II-Induced Cardiac Damage and Electrical Remodeling
Lajos Marko, Norbert Henke, Joon-Keun Park, Bastian Spallek, Fatimunnisa Qadri, Andras Balogh, Ingrid J Apel, Katherine I Oravecz-Wilson, Mira Choi, Lukasz Przybyl, Katrina J Binger, Nadine Haase, Nicola Wilck, Arnd Heuser, Verena Fokuhl, Juergen Ruland, Peter C Lucas, Linda M McAllister-Lucas, Friedrich C Luft, Ralf Dechend
Angiotensin (Ang) II is a potent mediator of both hypertension and cardiac damage; however, the mechanisms by which this occur rem..
Avoiding the oligomeric state: alpha B-crystallin inhibits fragmentation and induces dissociation of apolipoprotein C-II amyloid fibrils
Katrina J Binger, Heath Ecroyd, Shuo Yang, John A Carver, Geoffrey J Howlett, Michael DW Griffin
The in vivo aggregation of proteins into amyloid fibrils suggests that cellular mechanisms that normally prevent or reverse this a..