THE SYSTEMS BIOLOGY OF STEM CELLS

Grant number: FT150100330 | Funding period: 2016 - 2020

Completed

Abstract

Using new bioinformatic methods, this project aims to identify new classifiers of different stem cell populations, develop statistical models that address population heterogeneity and provide molecular predictors of the differentiation potential of stem cells. Understanding, predicting and directing the processes of differentiation are major goals in the disciplines of stem cell biology, developmental biology, tissue engineering and regenerative medicine. Molecular atlas projects have successfully revealed rules of genome output and regulation, by mining patterns that are evident across multiple cell types and datasets. By applying this philosophy to relevant, well-curated stem cell experime..

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Related publications (13)

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An integrated analysis of human myeloid cells identifies gaps in in vitro models of in vivo biology

Nadia Rajab, Paul W Angel, Yidi Deng, Jennifer Gu, Vanta Jameson, Mariola Kurowska-Stolarska, Simon Milling, Chris M Pacheco, Matt Rutar, Andrew L Laslett, Kim-Anh Le Cao, Jarny Choi, Christine A Wells

2021-06-08

The Stemformatics myeloid atlas is an integrated transcriptome atlas of human macrophages and dendritic cells that systematically ..

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A simple, scalable approach to building a cross-platform transcriptome atlas

Paul W Angel, Nadia Rajab, Yidi Deng, Chris M Pacheco, Tyrone Chen, Kim-Anh Le Cao, Jarny Choi, Christine A Wells

2020-09-01

Gene expression atlases have transformed our understanding of the development, composition and function of human tissues. New tech..

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A simple, scalable approach to building a cross-platform transcriptome atlas

Paul Angel, Nadia Rajab, Yidi Deng, Chris Pacheco, Tyrone Chen, Kim-Anh Lê Cao, Jarny Choi, Christine Wells

2020-03-11

<h4>ABSTRACT</h4> Gene expression atlases have transformed our understanding of the development, composition and function of human..

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Identification of a Sacral, Visceral Sensory Transcriptome in Embryonic and Adult Mice

CJA Smith-Anttila, EA Mason, CA Wells, BJ Aronow, PB Osborne, JR Keast

2020-01-01

Visceral sensory neurons encode distinct sensations from healthy organs and initiate pain states that are resistant to common anal..

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Transcriptional Profiling of Stem Cells: Moving from Descriptive to Predictive Paradigms

Christine A Wells, Jarny Choi

2019-08-13

Transcriptional profiling is a powerful tool commonly used to benchmark stem cells and their differentiated progeny. As the wealth..

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An integrated analysis of myeloid cells identifies gaps in in vitro models of in vivo biology

Nadia Rajab, Paul Angel, Yidi Deng, Jennifer Gu, Vanta Jameson, Mariola Kurowska-Stolarska, Simon Milling, Simon Milling, Chris Pacheco, Matt Rutar, Andrew Laslett, Kim Anh Lê Cao, Jarny Choi, Christine Wells

2019-07-31

<h4>Summary</h4> The Stemformatics myeloid atlas is an integrated transcriptome atlas of human macrophages and dendritic cells tha..

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Stemformatics: visualize and download curated stem cell data

Jarny Choi, Chris M Pacheco, Rowland Mosbergen, Othmar Korn, Tyrone Chen, Isha Nagpal, Steve Englart, Paul W Angel, Christine A Wells

2019-01-08

Stemformatics is an established gene expression data portal containing over 420 public gene expression datasets derived from micro..

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Designer macrophages: Pitfalls and opportunities for modelling macrophage phenotypes from pluripotent stem cells

Nadia Rajab, Matthew Rutar, Andrew L Laslett, Christine A Wells

2018-11-01

Macrophages are phagocytic immune cells resident in every tissue that are not only important for host defence, but are also involv..

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Dynamic Interplay of Innate and Adaptive Immunity During Sterile Retinal Inflammation: Insights From the Transcriptome

Riccardo Natoli, Elizabeth Mason, Haihan Jiao, Aaron Chuah, Hardip Patel, Nilisha Fernando, Krisztina Valter, Christine A Wells, Jan Provis, Matt Rutar

2018-07-18

The pathogenesis of many retinal degenerations, such as age-related macular degeneration (AMD), is punctuated by an ill-defined ne..

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Toll-Like Receptors Drive Specific Patterns of Tolerance and Training on Restimulation of Macrophages

Suzanne K Butcher, Christine E O'Carroll, Christine A Wells, Ruaidhri J Carmody

2018-05-14

Tolerance is a long-recognized property of macrophages that leads to an altered response to repeated or chronic exposure to endoto..

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Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease

J Kenneth Baillie, Andrew Bretherick, Christopher S Haley, Sara Clohisey, Alan Grays, Lucile PA Neyton, Jeffrey Barrett, Eli A Stahl, Albert Tenesa, Robin Andersson, J Ben Brown, Geoffrey J Faulkner, Marina Lizio, Ulf Schaefer, Carsten Daub, Masayoshi Itoh, Naoto Kondo, Timo Lassmann, Jun Kawai, Damian Mole

2018-03-01

Genetic variants underlying complex traits, including disease susceptibility, are enriched within the transcriptional regulatory e..

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Endotoxin Tolerance Induced by Different TLR Ligands

Suzanne Butcher, Christine O’Carroll, Christine Wells, Ruaidhrí Carmody

2018-01-24

Endotoxin tolerance is a long-recognised property of macrophages that leads to an altered response to repeated or chronic exposure..

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A molecular classification of human mesenchymal stromal cells

Florian Rohart, Elizabeth A Mason, Nicholas Matigian, Rowland Mosbergen, Othmar Korn, Tyrone Chen, Suzanne Butcher, Jatin Patel, Kerry Atkinson, Kiarash Khosrotehrani, Nicholas M Fisk, Kim-Anh Le Cao, Christine A Wells

2016-03-24

Mesenchymal stromal cells (MSC) are widely used for the study of mesenchymal tissue repair, and increasingly adopted for cell ther..

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