Acquired Resistance to Cdk4 Inhibition in Melanoma

PRMT5 and CDK4/6 inhibition result in distinctive patterns of alternative splicing in melanoma

Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E Sheppard, David L Goode

2023-11-02

Drugs targeting cyclin-dependent kinases 4 and 6 (CDK4/6) are promising new treatments for melanoma and other solid malignancies. ..

Cdk4/6 inhibition reprograms mitochondrial metabolism in brafv600 melanoma via a p53 dependent pathway

NT Santiappillai, S Abuhammad, A Slater, L Kirby, GA McArthur, KE Sheppard, LK Smith

2021-02-01

Cyclin‐dependent kinase 4 and 6 (CDK4/6) inhibitors are being tested in numerous clinical trials and are currently employed succes..

CDK4/6 inhibition in cancer: the cell cycle splicing connection

KE Sheppard, S AbuHammad

2019-11-02

Cyclin-dependent kinase −4 and −6 (CDK4/6) inhibitors are currently being assessed in clinical trials for the treatment of many ca..

Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

S AbuHammad, C Cullinane, C Martin, Z Bacolas, T Ward, H Chen, A Slater, K Ardley, L Kirby, KT Chan, N Brajanovski, LK Smith, AD Rao, EJ Lelliott, M Kleinschmidt, IA Vergara, AT Papenfuss, P Lau, P Ghosh, S Haupt

2019-09-03

Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are an established treatment in estrogen receptor-positive breast cancer and are c..