ENHANCING DISEASE VECTOR BIOSECURITY THROUGH HIGH DENSITY MOLECULAR MARKERS
Grant number: 1118640 | Funding period: 2017 - 2021
The outbreak of several diseases spread by mosquitoes is increasing rapidly around the world, driven by increased people movement spreading both viruses and disease vectors, a lack of effective vaccines and changing climatic conditions. In this proposal I aim to develop cutting edge molecular tools for identifying pathways of exotic mosquito introductions into Australia and a program that uses bacteria living inside mosquitoes in novel ways for disease suppression.
Related publications (44)
Lipidomic Profiling Reveals Concerted Temporal Patterns of Functionally Related Lipids in Aedes aegypti Females Following Blood Feeding
Meng-Jia Lau, Shuai Nie, Qiong Yang, Lawrence G Harshman, Cungui Mao, Nicholas A Williamson, Ary A Hoffmann
<jats:p>We conducted a lipidomic analysis of the whole body of female Aedes aegypti mosquitoes at different time points over the c..
Developing Wolbachia-based disease interventions for an extreme environment.
Perran A Ross, Samia Elfekih, Sophie Collier, Melissa J Klein, Su Shyan Lee, Michael Dunn, Sarah Jackson, Yexin Zhang, Jason K Axford, Xinyue Gu, Jessica L Home, Majed S Nassar, Prasad N Paradkar, Essam A Tawfik, Francis M Jiggins, Abdulaziz M Almalik, Mohamed B Al-Fageeh, Ary A Hoffmann
Aedes aegypti mosquitoes carrying self-spreading, virus-blocking Wolbachia bacteria are being deployed to suppress dengue transmis..
Urban population structure and dispersal of an Australian mosquito (Aedes notoscriptus) involved in disease transmission
Veronique Paris, Rahul V Rane, Peter T Mee, Stacey E Lynch, Ary A Hoffmann, Thomas L Schmidt
Dispersal is a critical parameter for successful pest control measures as it determines the rate of movement across target control..
Genomic and Phenotypic Comparisons Reveal Distinct Variants of Wolbachia Strain wAlbB
Julien Martinez, Perran A Ross, Xinyue Gu, Thomas H Ant, Shivan M Murdochy, Lily Tong, Ana da Silva Filipe, Ary A Hoffmann, Steven P Sinkins
The intracellular bacterium Wolbachia inhibits virus replication and is being harnessed around the world to fight mosquito-borne d..
Wolbachia inhibits ovarian formation and increases blood feeding rate in female Aedes aegypti
Meng-Jia Lau, Perran A Ross, Nancy M Endersby-Harshman, Qiong Yang, Ary A Hoffmann
Wolbachia, a gram-negative endosymbiotic bacterium widespread in arthropods, is well-known for changing the reproduction of its ho..
Spatio-Temporal Modelling Informing Wolbachia Replacement Releases in a Low Rainfall Climate
Dan Pagendam, Samia Elfekih, Majed S Nassar, Samuel Nelson, Abdulaziz M Almalik, Essam A Tawfik, Mohamed B Al-Fageeh, Ary A Hoffmann
Releases of Aedes aegypti carrying Wolbachia bacteria are known to suppress arbovirus transmission and reduce the incidence of vec..
Sex-specific distribution and classification of Wolbachia infections and mitochondrial DNA haplogroups in Aedes albopictus from the Indo-Pacific.
Qiong Yang, Jessica Chung, Katie L Robinson, Thomas L Schmidt, Perran A Ross, Jiaxin Liang, Ary A Hoffmann
The arbovirus vector Aedes albopictus (Asian tiger mosquito) is common throughout the Indo-Pacific region, where most global dengu..
A wMel Wolbachia variant in Aedes aegypti from field-collected Drosophila melanogaster with increased phenotypic stability under heat stress
Xinyue Gu, Perran A Ross, Julio Rodriguez-Andres, Katie L Robinson, Qiong Yang, Meng-Jia Lau, Ary A Hoffmann
Mosquito-borne diseases remain a major cause of morbidity and mortality. Population replacement strategies involving the wMel stra..
A decade of stability for wMel Wolbachia in natural Aedes aegypti populations
Perran P Ross, Katie M Robinson, Qiong Yang, Ashley A Callahan, Thomas Schmidt, Jason Axford, Marianne A Coquilleau, Kyran Staunton, Michael Townsend, Scott Ritchie, Meng-Jia Lau, Xinyue Gu, Ary Hoffmann
Mosquitoes carrying Wolbachia endosymbionts are being released in many countries for arbovirus control. The wMel strain of Wolbach..
Genetic stability of Aedes aegypti populations following invasion by wMel Wolbachia
Meng-Jia Lau, Thomas L Schmidt, Qiong Yang, Jessica Chung, Lucien Sankey, Perran A Ross, Ary A Hoffmann
BACKGROUND: Wolbachia wMel is the most commonly used strain in rear and release strategies for Aedes aegypti mosquitoes that aim t..
A wAlbB Wolbachia Transinfection Displays Stable Phenotypic Effects across Divergent Aedes aegypti Mosquito Backgrounds
Perran A Ross, Xinyue Gu, Katie L Robinson, Qiong Yang, Ellen Cottingham, Yifan Zhang, Heng Lin Yeap, Xuefen Xu, Nancy M Endersby-Harshman, Ary A Hoffmann
Aedes mosquitoes harboring intracellular Wolbachia bacteria are being released in arbovirus and mosquito control programs. With re..
Long-Range But Not Short-Range Attraction of Male Aedes aegypti (Diptera: Culicidae) Mosquitoes to Humans
Brogan A Amos, Ary A Hoffmann, Kyran M Staunton, Meng-Jia Lau, Thomas R Burkot, Perran A Ross
Female Aedes aegypti (Linnaeus) mosquitoes integrate multiple sensory cues to locate human hosts for blood meals. Although male Ae..
Wolbachia strain wAlbB maintains high density and dengue inhibition following introduction into a field population of Aedes aegypti
Noor Afizah Ahmad, Maria-Vittoria Mancini, Thomas H Ant, Julien Martinez, Ghazali MR Kamarul, Wasi A Nazni, Ary A Hoffmann, Steven P Sinkins
Aedes aegypti mosquitoes carrying the wAlbB Wolbachia strain show a reduced capacity to transmit dengue virus. wAlbB has been intr..
Infertility and fecundity loss of Wolbachia-infected Aedes aegypti hatched from quiescent eggs is expected to alter invasion dynamics
Meng-Jia Lau, Perran A Ross, Ary A Hoffmann
The endosymbiotic bacterium Wolbachia shows viral blocking in its mosquito host, leading to its use in arboviral disease control. ..
Spatial population genomics of a recent mosquito invasion
Thomas L Schmidt, T Swan, Jessica Chung, Stephan Karl, Samuel Demok, Qiong Yang, Matt A Field, Mutizwa Odwell Muzari, Gerhard Ehlers, Mathew Brugh, Rodney Bellwood, Peter Horne, Thomas R Burkot, Scott Ritchie, Ary A Hoffmann
Population genomic approaches can characterize dispersal across a single generation through to many generations in the past, bridg..
Wolbachia Genome Stability and mtDNA Variants in Aedes aegypti Field Populations Eight Years after Release
Bixing Huang, Qiong Yang, Ary A Hoffmann, Scott A Ritchie, Andrew F van den Hurk, David Warrilow
A dengue suppression strategy based on release of Aedes aegypti mosquitoes infected with the bacterium Wolbachia pipientis is bein..
Impacts of Low Temperatures on Wolbachia (Rickettsiales: Rickettsiaceae)-Infected Aedes aegypti (Diptera: Culicidae)
Meng-Jia Lau, Perran A Ross, Nancy M Endersby-Harshman, Ary A Hoffmann
In recent decades, the occurrence and distribution of arboviral diseases transmitted by Aedes aegypti mosquitoes has increased. In..
Frequency of kdr mutations in the voltage-sensitive sodium channel (V-SSC) gene in Aedes aegypti from Yogyakarta and implications for Wolbachia-infected mosquito trials
Juli Rochmijati Wuliandari, Ary A Hoffmann, Warsito Tantowijoyo, Nancy M Endersby-Harshman
Background In the inner city of Yogyakarta, Indonesia, insecticide resistance is expected in the main dengue vector, Aedes aegypti..
Heterogeneous genetic invasions of three insecticide resistance mutations in Indo-Pacific populations of Aedes aegypti (L.)
Nancy M Endersby-Harshman, Thomas L Schmidt, Jessica Chung, Anthony van Rooyen, Andrew R Weeks, Ary A Hoffmann
Nations throughout the Indo-Pacific region use pyrethroid insecticides to control Aedes aegypti, the mosquito vector of dengue, of..
An elusive endosymbiont: Does Wolbachia occur naturally in Aedes aegypti?
Perran A Ross, Ashley G Callahan, Qiong Yang, Moshe Jasper, Mohd AK Arif, Ahmad Noor Afizah, Wasi A Nazni, Ary A Hoffmann
Wolbachia are maternally inherited endosymbiotic bacteria found within many insect species. Aedes mosquitoes experimentally infect..
Heatwaves cause fluctuations in wMel Wolbachia densities and frequencies in Aedes aegypti
Perran A Ross, Jason K Axford, Qiong Yang, Kyran M Staunton, Scott A Ritchie, Kelly M Richardson, Ary A Hoffmann
Aedes aegypti mosquitoes infected with the wMel strain of Wolbachia are being released into natural mosquito populations in the tr..
Measuring the Host-Seeking Ability of Aedes aegypti Destined for Field Release
Meng-Jia Lau, Nancy M Endersby-Harshman, Jason K Axford, Scott A Ritchie, Ary A Hoffmann, Perran A Ross
Host seeking is an essential process in mosquito reproduction. Field releases of modified mosquitoes for population replacement re..
Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control
Wasi A Nazni, Ary A Hoffmann, Ahmad NoorAfizah, Yoon Ling Cheong, Maria V Mancini, Nicholas Golding, Ghazali MR Kamarul, Mohd AK Arif, Hasim Thohir, Halim NurSyamimi, M Zabari ZatilAqmar, Mazni NurRuqqayah, Amran NorSyazwani, Azmi Faiz, Francis-Rudin MN Irfan, Subramaniam Rubaaini, Nasir Nuradila, Nasir MN Nizam, Saidin M Irwan, Nancy M Endersby-Harshman
Dengue has enormous health impacts globally. A novel approach to decrease dengue incidence involves the introduction of Wolbachia ..
A LAMP assay for the rapid and robust assessment of Wolbachia infection in Aedes aegypti under field and laboratory conditions
Moshe E Jasper, Qiong Yang, Perran A Ross, Nancy Endersby-Harshman, Nicholas Bell, Ary A Hoffmann
With Wolbachia-based arbovirus control programs being scaled and operationalised around the world, cost effective and reliable det..
A genomic approach to inferring kinship reveals limited intergenerational dispersal in the yellow fever mosquito
Moshe Jasper, Thomas L Schmidt, Nazni W Ahmad, Steven P Sinkins, Ary A Hoffmann
Understanding past dispersal and breeding events can provide insight into ecology and evolution and can help inform strategies for..
Loss of cytoplasmic incompatibility in Wolbachia-infected Aedes aegypti under field conditions
Perran A Ross, Scott A Ritchie, Jason K Axford, Ary A Hoffmann
Wolbachia bacteria are now being introduced into Aedes aegypti mosquito populations for dengue control. When Wolbachia infections ..
Contrasting Patterns of Virus Protection and Functional Incompatibility Genes in Two Conspecific Wolbachia Strains from Drosophila pandora
Angelique K Asselin, Simon Villegas-Ospina, Ary A Hoffmann, Jeremy C Brownlie, Karyn N Johnson
Wolbachia infections can present different phenotypes in hosts, including different forms of reproductive manipulation and antivir..
Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia.
Peter A Ryan, Andrew P Turley, Geoff Wilson, Tim P Hurst, Kate Retzki, Jack Brown-Kenyon, Lauren Hodgson, Nichola Kenny, Helen Cook, Brian L Montgomery, Christopher J Paton, Scott A Ritchie, Ary A Hoffmann, Nicholas P Jewell, Stephanie K Tanamas, Katherine L Anders, Cameron P Simmons, Scott L O'Neill
Background: The wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and subsequently shown in ..
Effects of Alternative Blood Sources on Wolbachia Infected Aedes aegypti Females within and across Generations
Veronique Paris, Ellen Cottingham, Perran A Ross, Jason K Axford, Ary A Hoffmann
Wolbachia bacteria have been identified as a tool for reducing the transmission of arboviruses transmitted by Aedes aegypti. Resea..
No detectable effect of Wolbachia wMel on the prevalence and abundance of the RNA virome of Drosophila melanogaster
Mang Shi, Vanessa L White, Timothy Schlub, John-Sebastian Eden, Ary A Hoffmann, Edward C Holmes
Wolbachia is an endosymbiotic bacterium that can block viral infections in arthropods, generating interest in its potential to con..
Rapid Global Spread of wRi-like Wolbachia across Multiple Drosophila
Michael Turelli, Brandon S Cooper, Kelly M Richardson, Paul S Ginsberg, Brooke Peckenpaugh, Chenling X Antelope, Kevin J Kim, Michael R May, Antoine Abrieux, Derek A Wilson, Michael J Bronski, Brian R Moore, Jian-Jun Gao, Michael B Eisen, Joanna C Chiu, William R Conner, Ary A Hoffmann
Maternally transmitted Wolbachia, Spiroplasma, and Cardinium bacteria are common in insects , but their interspecific spread is..
Wolbachia-induced loss of male fertility is likely related to branch chain amino acid biosynthesis and iLvE in Laodelphax striatellus
Jia-Fei Ju, Ary A Hoffmann, Yan-Kai Zhang, Xing-Zhi Duan, Yan Guo, Jun-Tao Gong, Wen-Chao Zhu, Xiao-Yue Hong
Wolbachia are endosymbionts that infect many species of arthropods and nematodes. Wolbachia-induced cytoplasmic incompatibility (C..