ENHANCING DISEASE VECTOR BIOSECURITY THROUGH HIGH DENSITY MOLECULAR MARKERS

Lipidomic Profiling Reveals Concerted Temporal Patterns of Functionally Related Lipids in Aedes aegypti Females Following Blood Feeding

Meng-Jia Lau, Shuai Nie, Qiong Yang, Lawrence G Harshman, Cungui Mao, Nicholas A Williamson, Ary A Hoffmann

2023-03-13

<jats:p>We conducted a lipidomic analysis of the whole body of female Aedes aegypti mosquitoes at different time points over the c..

Developing Wolbachia-based disease interventions for an extreme environment.

Perran A Ross, Samia Elfekih, Sophie Collier, Melissa J Klein, Su Shyan Lee, Michael Dunn, Sarah Jackson, Yexin Zhang, Jason K Axford, Xinyue Gu, Jessica L Home, Majed S Nassar, Prasad N Paradkar, Essam A Tawfik, Francis M Jiggins, Abdulaziz M Almalik, Mohamed B Al-Fageeh, Ary A Hoffmann

2023-01-01

Aedes aegypti mosquitoes carrying self-spreading, virus-blocking Wolbachia bacteria are being deployed to suppress dengue transmis..

Urban population structure and dispersal of an Australian mosquito (Aedes notoscriptus) involved in disease transmission

Veronique Paris, Rahul V Rane, Peter T Mee, Stacey E Lynch, Ary A Hoffmann, Thomas L Schmidt

2022-12-20

Dispersal is a critical parameter for successful pest control measures as it determines the rate of movement across target control..

Fitness costs of Wolbachia shift in locally-adapted Aedes aegypti mosquitoes.

Perran A Ross, Ary A Hoffmann

2022-12-01

Aedes aegypti mosquito eggs can remain quiescent for many months before hatching, allowing populations to persist through unfavour..

Genomic and Phenotypic Comparisons Reveal Distinct Variants of Wolbachia Strain wAlbB

Julien Martinez, Perran A Ross, Xinyue Gu, Thomas H Ant, Shivan M Murdochy, Lily Tong, Ana da Silva Filipe, Ary A Hoffmann, Steven P Sinkins

2022-11-01

The intracellular bacterium Wolbachia inhibits virus replication and is being harnessed around the world to fight mosquito-borne d..

Wolbachia inhibits ovarian formation and increases blood feeding rate in female Aedes aegypti

Meng-Jia Lau, Perran A Ross, Nancy M Endersby-Harshman, Qiong Yang, Ary A Hoffmann

2022-11-01

Wolbachia, a gram-negative endosymbiotic bacterium widespread in arthropods, is well-known for changing the reproduction of its ho..

Spatio-Temporal Modelling Informing Wolbachia Replacement Releases in a Low Rainfall Climate

Dan Pagendam, Samia Elfekih, Majed S Nassar, Samuel Nelson, Abdulaziz M Almalik, Essam A Tawfik, Mohamed B Al-Fageeh, Ary A Hoffmann

2022-10-01

Releases of Aedes aegypti carrying Wolbachia bacteria are known to suppress arbovirus transmission and reduce the incidence of vec..

Sex-specific distribution and classification of Wolbachia infections and mitochondrial DNA haplogroups in Aedes albopictus from the Indo-Pacific.

Qiong Yang, Jessica Chung, Katie L Robinson, Thomas L Schmidt, Perran A Ross, Jiaxin Liang, Ary A Hoffmann

2022-04-01

The arbovirus vector Aedes albopictus (Asian tiger mosquito) is common throughout the Indo-Pacific region, where most global dengu..

A wMel Wolbachia variant in Aedes aegypti from field-collected Drosophila melanogaster with increased phenotypic stability under heat stress

Xinyue Gu, Perran A Ross, Julio Rodriguez-Andres, Katie L Robinson, Qiong Yang, Meng-Jia Lau, Ary A Hoffmann

2022-03-23

Mosquito-borne diseases remain a major cause of morbidity and mortality. Population replacement strategies involving the wMel stra..

A decade of stability for wMel Wolbachia in natural Aedes aegypti populations

Perran P Ross, Katie M Robinson, Qiong Yang, Ashley A Callahan, Thomas Schmidt, Jason Axford, Marianne A Coquilleau, Kyran Staunton, Michael Townsend, Scott Ritchie, Meng-Jia Lau, Xinyue Gu, Ary Hoffmann

2022-02-23

Mosquitoes carrying Wolbachia endosymbionts are being released in many countries for arbovirus control. The wMel strain of Wolbach..

Genetic stability of Aedes aegypti populations following invasion by wMel Wolbachia

Meng-Jia Lau, Thomas L Schmidt, Qiong Yang, Jessica Chung, Lucien Sankey, Perran A Ross, Ary A Hoffmann

2021-12-14

BACKGROUND: Wolbachia wMel is the most commonly used strain in rear and release strategies for Aedes aegypti mosquitoes that aim t..

Estimating dispersal using close kin dyads: The kindisperse R package

Moshe E Jasper, Ary A Hoffmann, Thomas L Schmidt

2021-10-10

Investigating dispersal in animal populations can be difficult, particularly for taxa that are hard to directly observe such as th..

A wAlbB Wolbachia Transinfection Displays Stable Phenotypic Effects across Divergent Aedes aegypti Mosquito Backgrounds

Perran A Ross, Xinyue Gu, Katie L Robinson, Qiong Yang, Ellen Cottingham, Yifan Zhang, Heng Lin Yeap, Xuefen Xu, Nancy M Endersby-Harshman, Ary A Hoffmann

2021-10-01

Aedes mosquitoes harboring intracellular Wolbachia bacteria are being released in arbovirus and mosquito control programs. With re..

Long-Range But Not Short-Range Attraction of Male Aedes aegypti (Diptera: Culicidae) Mosquitoes to Humans

Brogan A Amos, Ary A Hoffmann, Kyran M Staunton, Meng-Jia Lau, Thomas R Burkot, Perran A Ross

2021-09-24

Female Aedes aegypti (Linnaeus) mosquitoes integrate multiple sensory cues to locate human hosts for blood meals. Although male Ae..

A diagnostic primer pair to distinguish between wMel and wAlbB Wolbachia infections

Meng-Jia Lau, Ary A Hoffmann, Nancy M Endersby-Harshman

2021-09-23

Detection of the Wolbachia endosymbiont in Aedes aegypti mosquitoes through real-time polymerase chain reaction assays is widely u..

Improving mosquito control strategies with population genomics

Thomas L Schmidt, Nancy M Endersby-Harshman, Ary A Hoffmann

2021-09-15

Mosquito control strategies increasingly apply knowledge from population genomics research. This review highlights recent applicat..

Unbiased population heterozygosity estimates from genome-wide sequence data

Thomas L Schmidt, Moshe-Elijah Jasper, Andrew R Weeks, Ary A Hoffmann

2021-07-01

Heterozygosity is a metric of genetic variability frequently used to inform the management of threatened taxa. Estimating observed..

Wolbachia strain wAlbB maintains high density and dengue inhibition following introduction into a field population of Aedes aegypti

Noor Afizah Ahmad, Maria-Vittoria Mancini, Thomas H Ant, Julien Martinez, Ghazali MR Kamarul, Wasi A Nazni, Ary A Hoffmann, Steven P Sinkins

2021-02-15

Aedes aegypti mosquitoes carrying the wAlbB Wolbachia strain show a reduced capacity to transmit dengue virus. wAlbB has been intr..

Infertility and fecundity loss of Wolbachia-infected Aedes aegypti hatched from quiescent eggs is expected to alter invasion dynamics

Meng-Jia Lau, Perran A Ross, Ary A Hoffmann

2021-02-01

The endosymbiotic bacterium Wolbachia shows viral blocking in its mosquito host, leading to its use in arboviral disease control. ..

Spatial population genomics of a recent mosquito invasion

Thomas L Schmidt, T Swan, Jessica Chung, Stephan Karl, Samuel Demok, Qiong Yang, Matt A Field, Mutizwa Odwell Muzari, Gerhard Ehlers, Mathew Brugh, Rodney Bellwood, Peter Horne, Thomas R Burkot, Scott Ritchie, Ary A Hoffmann

2021-01-24

Population genomic approaches can characterize dispersal across a single generation through to many generations in the past, bridg..

RNA virome diversity and Wolbachia infection in individual Drosophila simulans flies

Ayda Susana Ortiz-Baez, Mang Shi, Ary A Hoffmann, Edward C Holmes

2021-01-01

The endosymbiont bacteria of the genus Wolbachia are associated with multiple mutualistic effects on insect biology, including nut..

Wolbachia Genome Stability and mtDNA Variants in Aedes aegypti Field Populations Eight Years after Release

Bixing Huang, Qiong Yang, Ary A Hoffmann, Scott A Ritchie, Andrew F van den Hurk, David Warrilow

2020-10-23

A dengue suppression strategy based on release of Aedes aegypti mosquitoes infected with the bacterium Wolbachia pipientis is bein..

Impacts of Low Temperatures on Wolbachia (Rickettsiales: Rickettsiaceae)-Infected Aedes aegypti (Diptera: Culicidae)

Meng-Jia Lau, Perran A Ross, Nancy M Endersby-Harshman, Ary A Hoffmann

2020-09-01

In recent decades, the occurrence and distribution of arboviral diseases transmitted by Aedes aegypti mosquitoes has increased. In..

Frequency of kdr mutations in the voltage-sensitive sodium channel (V-SSC) gene in Aedes aegypti from Yogyakarta and implications for Wolbachia-infected mosquito trials

Juli Rochmijati Wuliandari, Ary A Hoffmann, Warsito Tantowijoyo, Nancy M Endersby-Harshman

2020-08-24

Background In the inner city of Yogyakarta, Indonesia, insecticide resistance is expected in the main dengue vector, Aedes aegypti..

Heterogeneous genetic invasions of three insecticide resistance mutations in Indo-Pacific populations of Aedes aegypti (L.)

Nancy M Endersby-Harshman, Thomas L Schmidt, Jessica Chung, Anthony van Rooyen, Andrew R Weeks, Ary A Hoffmann

2020-04-21

Nations throughout the Indo-Pacific region use pyrethroid insecticides to control Aedes aegypti, the mosquito vector of dengue, of..

Persistent deleterious effects of a deleterious Wolbachia infection

Perran A Ross, Jason K Axford, Ashley G Callahan, Kelly M Richardson, Ary A Hoffmann

2020-04-03

Wolbachia are being used to reduce dengue transmission by Aedes aegypti mosquitoes around the world. To date releases have mostly ..

An elusive endosymbiont: Does Wolbachia occur naturally in Aedes aegypti?

Perran A Ross, Ashley G Callahan, Qiong Yang, Moshe Jasper, Mohd AK Arif, Ahmad Noor Afizah, Wasi A Nazni, Ary A Hoffmann

2020-02-16

Wolbachia are maternally inherited endosymbiotic bacteria found within many insect species. Aedes mosquitoes experimentally infect..

Heatwaves cause fluctuations in wMel Wolbachia densities and frequencies in Aedes aegypti

Perran A Ross, Jason K Axford, Qiong Yang, Kyran M Staunton, Scott A Ritchie, Kelly M Richardson, Ary A Hoffmann

2020-01-01

Aedes aegypti mosquitoes infected with the wMel strain of Wolbachia are being released into natural mosquito populations in the tr..

Measuring the Host-Seeking Ability of Aedes aegypti Destined for Field Release

Meng-Jia Lau, Nancy M Endersby-Harshman, Jason K Axford, Scott A Ritchie, Ary A Hoffmann, Perran A Ross

2020-01-01

Host seeking is an essential process in mosquito reproduction. Field releases of modified mosquitoes for population replacement re..

Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control

Wasi A Nazni, Ary A Hoffmann, Ahmad NoorAfizah, Yoon Ling Cheong, Maria V Mancini, Nicholas Golding, Ghazali MR Kamarul, Mohd AK Arif, Hasim Thohir, Halim NurSyamimi, M Zabari ZatilAqmar, Mazni NurRuqqayah, Amran NorSyazwani, Azmi Faiz, Francis-Rudin MN Irfan, Subramaniam Rubaaini, Nasir Nuradila, Nasir MN Nizam, Saidin M Irwan, Nancy M Endersby-Harshman

2019-12-16

Dengue has enormous health impacts globally. A novel approach to decrease dengue incidence involves the introduction of Wolbachia ..

A LAMP assay for the rapid and robust assessment of Wolbachia infection in Aedes aegypti under field and laboratory conditions

Moshe E Jasper, Qiong Yang, Perran A Ross, Nancy Endersby-Harshman, Nicholas Bell, Ary A Hoffmann

2019-11-20

With Wolbachia-based arbovirus control programs being scaled and operationalised around the world, cost effective and reliable det..

Does membrane feeding compromise the quality of Aedes aegypti mosquitoes?

Perran A Ross, Meng-Jia Lau, Ary A Hoffmann

2019-11-06

Modified Aedes aegypti mosquitoes are being mass-reared for release in disease control programs around the world. Releases involvi..

A genomic approach to inferring kinship reveals limited intergenerational dispersal in the yellow fever mosquito

Moshe Jasper, Thomas L Schmidt, Nazni W Ahmad, Steven P Sinkins, Ary A Hoffmann

2019-09-01

Understanding past dispersal and breeding events can provide insight into ecology and evolution and can help inform strategies for..

Life History Effects Linked to an Advantage for wAu Wolbachia in Drosophila

Li-Jun Cao, Weibin Jiang, Ary A Hoffmann

2019-05-01

Wolbachia endosymbiont infections can persist and spread in insect populations without causing apparent effects on reproduction of..

Loss of cytoplasmic incompatibility in Wolbachia-infected Aedes aegypti under field conditions

Perran A Ross, Scott A Ritchie, Jason K Axford, Ary A Hoffmann

2019-04-01

Wolbachia bacteria are now being introduced into Aedes aegypti mosquito populations for dengue control. When Wolbachia infections ..

Contrasting Patterns of Virus Protection and Functional Incompatibility Genes in Two Conspecific Wolbachia Strains from Drosophila pandora

Angelique K Asselin, Simon Villegas-Ospina, Ary A Hoffmann, Jeremy C Brownlie, Karyn N Johnson

2019-03-01

Wolbachia infections can present different phenotypes in hosts, including different forms of reproductive manipulation and antivir..

Cross-Generational Effects of Heat Stress on Fitness and Wolbachia Density in Aedes aegypti Mosquitoes

Isabelle Jia-Hui Foo, Ary A Hoffmann, Perran A Ross

2019-03-01

Aedes aegypti mosquitoes infected with Wolbachia symbionts are now being released into the field to control the spread of pathogen..

Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia.

Peter A Ryan, Andrew P Turley, Geoff Wilson, Tim P Hurst, Kate Retzki, Jack Brown-Kenyon, Lauren Hodgson, Nichola Kenny, Helen Cook, Brian L Montgomery, Christopher J Paton, Scott A Ritchie, Ary A Hoffmann, Nicholas P Jewell, Stephanie K Tanamas, Katherine L Anders, Cameron P Simmons, Scott L O'Neill

2019-01-01

Background: The wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and subsequently shown in ..

Evolutionary Ecology of Wolbachia Releases for Disease Control

Perran A Ross, Michael Turelli, Ary A Hoffmann

2019-01-01

Wolbachia is an endosymbiotic Alphaproteobacteria that can suppress insect-borne diseases through decreasing host virus transmissi..

Effects of Alternative Blood Sources on Wolbachia Infected Aedes aegypti Females within and across Generations

Veronique Paris, Ellen Cottingham, Perran A Ross, Jason K Axford, Ary A Hoffmann

2018-12-01

Wolbachia bacteria have been identified as a tool for reducing the transmission of arboviruses transmitted by Aedes aegypti. Resea..

No detectable effect of Wolbachia wMel on the prevalence and abundance of the RNA virome of Drosophila melanogaster

Mang Shi, Vanessa L White, Timothy Schlub, John-Sebastian Eden, Ary A Hoffmann, Edward C Holmes

2018-07-25

Wolbachia is an endosymbiotic bacterium that can block viral infections in arthropods, generating interest in its potential to con..

Rates and Patterns of Laboratory Adaptation in (Mostly) Insects

Ary A Hoffmann, Perran A Ross

2018-04-01

Insects and other invertebrates can readily adapt to a range of environmental conditions and these include conditions used in arti..

Rapid Global Spread of wRi-like Wolbachia across Multiple Drosophila

Michael Turelli, Brandon S Cooper, Kelly M Richardson, Paul S Ginsberg, Brooke Peckenpaugh, Chenling X Antelope, Kevin J Kim, Michael R May, Antoine Abrieux, Derek A Wilson, Michael J Bronski, Brian R Moore, Jian-Jun Gao, Michael B Eisen, Joanna C Chiu, William R Conner, Ary A Hoffmann

2018-03-19

Maternally transmitted Wolbachia, Spiroplasma, and Cardinium bacteria are common in insects [1], but their interspecific spread is..

Wolbachia-induced loss of male fertility is likely related to branch chain amino acid biosynthesis and iLvE in Laodelphax striatellus

Jia-Fei Ju, Ary A Hoffmann, Yan-Kai Zhang, Xing-Zhi Duan, Yan Guo, Jun-Tao Gong, Wen-Chao Zhu, Xiao-Yue Hong

2017-06-01

Wolbachia are endosymbionts that infect many species of arthropods and nematodes. Wolbachia-induced cytoplasmic incompatibility (C..