NEUROBIOLOGY OF CENTRAL RESPIRATORY CONTROL

Grant number: 1121376 | Funding period: 2017 - 2020

Completed

Abstract

A novel sensory neural circuit has been identified innervating the airways and lungs. The anatomical organisation of this circuit has been described to some extent in previous studies, however there is a significant gap in knowledge with respect to its functional importance. This project will develop methods to address this knowledge gap and in doing so the project will firstly describe how this circuit controls breathing under normal conditions and secondly how this becomes dysregulated during

Related publications (7)

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Jugular vagal ganglia neurons and airway nociception: A target for treating chronic cough

Aung Aung Kywe Moe, Alice E McGovern, Stuart B Mazzone

2021-06-01

The airways receive a dense supply of sensory nerve fibers that are responsive to damaging or potentially injurious stimuli. These..

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The impact of influenza pulmonary infection and inflammation on vagal bronchopulmonary sensory neurons

Nathalie AJ Verzele, Brendon Y Chua, Charity W Law, Albert Zhang, Matthew E Ritchie, Oliver Wightman, Isaac N Edwards, Katina D Hulme, Conor J Bloxham, Helle Bielefeldt-Ohmann, Matthew W Trewella, Aung Aung Kywe Moe, Keng Yih Chew, Stuart B Mazzone, Kirsty R Short, Alice E McGovern

2021-03-01

Influenza A virus (IAV) is rapidly detected in the airways by the immune system, with resident parenchymal cells and leukocytes or..

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Mini Review: Central Organization of Airway Afferent Nerve Circuits

Robert Behrens, Alice E McGovern, Michael J Farrell, Aung Aung Kywe Moe, Stuart B Mazzone

2021-01-23

Airway afferents monitor the local chemical and physical micro-environments in the airway wall and lungs and send this information..

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Descending Modulation of Laryngeal Vagal Sensory Processing in the Brainstem Orchestrated by the Submedius Thalamic Nucleus

Stuart B Mazzone, Tara G Bautista, Anthony JM Verberne, Matthew W Trewella, Michael J Farrell, Alice E McGovern

2020-12-02

The nodose and jugular vagal ganglia supply sensory innervation to the airways and lungs. Jugular vagal airway sensory neurons wir..

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Transcriptional Profiling of Individual Airway Projecting Vagal Sensory Neurons

Stuart B Mazzone, Luyi Tian, Aung Aung Kywe Moe, Matthew W Trewella, Matthew E Ritchie, Alice E McGovern

2019-10-19

Bronchopulmonary sensory neurons are derived from the vagal sensory ganglia and are essential for monitoring the physical and chem..

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Translational review: Neuroimmune mechanisms in cough and emerging therapeutic targets

Alice E McGovern, Kirsty R Short, Aung Aung Kywe Moe, Stuart B Mazzone

2018-11-01

Cough is an essential defensive behavior for maintaining airway patency and to protect the lungs from potentially harmful agents. ..

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Translating Cough Mechanisms Into Better Cough Suppressants

Jennifer A Keller, Alice E McGovern, Stuart B Mazzone

2017-10-01

Chronic cough is a significant problem, and in many patients cough remains refractive to both disease-specific therapies and curre..

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