NEUROBIOLOGY OF CENTRAL RESPIRATORY CONTROL
Grant number: 1121376 | Funding period: 2017 - 2020
A novel sensory neural circuit has been identified innervating the airways and lungs. The anatomical organisation of this circuit has been described to some extent in previous studies, however there is a significant gap in knowledge with respect to its functional importance. This project will develop methods to address this knowledge gap and in doing so the project will firstly describe how this circuit controls breathing under normal conditions and secondly how this becomes dysregulated during
Related publications (7)
The impact of influenza pulmonary infection and inflammation on vagal bronchopulmonary sensory neurons
Nathalie AJ Verzele, Brendon Y Chua, Charity W Law, Albert Zhang, Matthew E Ritchie, Oliver Wightman, Isaac N Edwards, Katina D Hulme, Conor J Bloxham, Helle Bielefeldt-Ohmann, Matthew W Trewella, Aung Aung Kywe Moe, Keng Yih Chew, Stuart B Mazzone, Kirsty R Short, Alice E McGovern
Influenza A virus (IAV) is rapidly detected in the airways by the immune system, with resident parenchymal cells and leukocytes or..
Mini Review: Central Organization of Airway Afferent Nerve Circuits
Robert Behrens, Alice E McGovern, Michael J Farrell, Aung Aung Kywe Moe, Stuart B Mazzone
Airway afferents monitor the local chemical and physical micro-environments in the airway wall and lungs and send this information..
Descending Modulation of Laryngeal Vagal Sensory Processing in the Brainstem Orchestrated by the Submedius Thalamic Nucleus
Stuart B Mazzone, Tara G Bautista, Anthony JM Verberne, Matthew W Trewella, Michael J Farrell, Alice E McGovern
The nodose and jugular vagal ganglia supply sensory innervation to the airways and lungs. Jugular vagal airway sensory neurons wir..
Transcriptional Profiling of Individual Airway Projecting Vagal Sensory Neurons
Stuart B Mazzone, Luyi Tian, Aung Aung Kywe Moe, Matthew W Trewella, Matthew E Ritchie, Alice E McGovern
Bronchopulmonary sensory neurons are derived from the vagal sensory ganglia and are essential for monitoring the physical and chem..
Translational review: Neuroimmune mechanisms in cough and emerging therapeutic targets
Alice E McGovern, Kirsty R Short, Aung Aung Kywe Moe, Stuart B Mazzone
Cough is an essential defensive behavior for maintaining airway patency and to protect the lungs from potentially harmful agents. ..