HARNESSING SYSTEMS BIOLOGY TO TACKLE NEGLECTED TROPICAL DISEASES
Grant number: 1127033 | Funding period: 2017 - 2020
Neglected tropical diseases (NTD) have a devastating, long-term impact on billions of humans globally. No vaccines are available, and mass treatment strategies are leading to drug resistance. Thus, there is a major need to develop radically new and advanced interventions. By creating substantially enhanced and automated bioinformatics tools, I will unlock the fundamental molecular biology of key NTDs to underpin the design of new drugs, vaccines and diagnostics as translational outcomes.
Related publications (2)
Comparative genome analysis indicates high evolutionary potential of pathogenicity genes in Colletotrichum tanaceti
Ruvini Lelwala, Pasi K Korhonen, Neil D Young, Jason B Scott, Peter K Ades, Robin B Gasser, Paul WJ Taylor
Colletotrichum tanaceti is an emerging foliar fungal pathogen of commercially grown pyrethrum (Tanacetum cinerariifolium). Despite..
yy Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain
Sarah Preston, Pasi K Korhonen, Laurent Mouchiroud, Matteo Cornaglia, Sean L McGee, Neil D Young, Rohan A Davis, Simon Crawford, Cameron Nowell, Brendan RE Ansell, Gillian M Fisher, Katherine T Andrews, Bill CH Chang, Martin AM Gijs, Paul W Sternberg, Johan Auwerx, Jonathan Baell, Andreas Hofmann, Abdul Jabbar, Robin B Gasser
As a result of limited classes of anthelmintics and an over-reliance on chemical control, there is a great need to discover new co..